{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:12:01Z","timestamp":1785795121786,"version":"3.56.0"},"reference-count":58,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T00:00:00Z","timestamp":1567641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07607-8, 2014\/08913-8 and 2015\/25597-5"],"award-info":[{"award-number":["2013\/07607-8, 2014\/08913-8 and 2015\/25597-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Distinct environmental insults might interact with fructose consumption and contribute to the development of metabolic disorders. To address whether in utero glucocorticoid exposure and fructose intake modulate metabolic responses, adult female Wistar rats were exposed to dexamethasone (DEX) during pregnancy, and the offspring were administered fructose at a later time. Briefly, dams received DEX during the third period of pregnancy, while control dams remained untreated. Offspring born to control and DEX-treated mothers were defined as CTL-off and DEX-off, respectively, while untreated animals were designated CTL-off-CTL and DEX-off-CTL. CLT-off and DEX-off treated with 10% fructose in the drinking water for 8 weeks are referred to as CTL-off-FRU and DEX-off-FRU. We found that fructose promoted glucose intolerance and whole-body gluconeogenesis in both CTL-off-FRU and DEX-off-FRU animals. On the other hand, hepatic lipid accumulation was significantly stimulated in DEX-off-FRU rats when compared to the CTL-off-FRU group. The DEX-off-FRU group also displayed impaired very-low-density lipoprotein (VLDL) production and reduced hepatic expression of apoB, mttp, and sec22b. DEX-off-FRU has lower hepatic levels of autophagy markers. Taken together, our results support the unprecedented notion that in utero glucocorticoid exposure exacerbates hepatic steatosis caused by fructose consumption later in life.<\/jats:p>","DOI":"10.3390\/nu11092114","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T02:59:22Z","timestamp":1567738762000},"page":"2114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["In Utero Dexamethasone Exposure Exacerbates Hepatic Steatosis in Rats That Consume Fructose During Adulthood"],"prefix":"10.3390","volume":"11","author":[{"given":"Tanyara B.","family":"Payolla","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-1130","authenticated-orcid":false,"given":"Caio J.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-4364","authenticated-orcid":false,"given":"Fabio T.","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-5410","authenticated-orcid":false,"given":"Gilson M.","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gizela A.","family":"Zonta","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frhancielly S.","family":"Sodr\u00e9","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina V.","family":"Campos","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiphe N.","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel F.","family":"Anh\u00ea","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Sao Paulo 13083-887, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0192-8869","authenticated-orcid":false,"given":"Silvana","family":"Bordin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.HYP.10.5.512","article-title":"Fructose-induced insulin resistance and hypertension in rats","volume":"10","author":"Hwang","year":"1987","journal-title":"Hypertension"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0022-2275(20)39481-5","article-title":"Utilization of exogenous free fatty acids for the production of very low density lipoprotein triglyceride by livers of carbohydrate-fed rats","volume":"12","author":"Schonfeld","year":"1971","journal-title":"J. Lipid Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/0026-0495(91)90061-Z","article-title":"Partial characterization of the fructose-induced defect in very-low-density lipoprotein triglyceride metabolism","volume":"40","author":"Mamo","year":"1991","journal-title":"Metabolism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0026-0495(95)90235-X","article-title":"Decreased sensitivity to the inhibitory effect of insulin on the secretion of very-low-density lipoprotein in cultured hepatocytes from fructose-fed rats","volume":"44","author":"Wiggins","year":"1995","journal-title":"Metabolism"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0022-2275(20)30037-7","article-title":"Chronic exogenous insulin and chronic carbohydrate supplementation increase de novo VLDL triglyceride fatty acid production in rats","volume":"38","author":"Park","year":"1997","journal-title":"J. Lipid Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jnutbio.2013.10.014","article-title":"Liquid fructose down-regulates liver insulin receptor substrate 2 and gluconeogenic enzymes by modifying nutrient sensing factors in rats","volume":"25","author":"Rebollo","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"R1200","DOI":"10.1152\/ajpregu.00230.2016","article-title":"Sex differences in the metabolic dysfunction and insulin resistance of skeletal muscle glucose transport following high fructose ingestion","volume":"311","author":"Rattanavichit","year":"2016","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Faria, J.A., de Ara\u00fajo, T.M., Razolli, D.S., Ign\u00e1cio-Souza, L.M., Souza, D.N., Bordin, S., and Anh\u00ea, G.F. (2017). Metabolic Impact of Light Phase-Restricted Fructose Consumption Is Linked to Changes in Hypothalamic AMPK Phosphorylation and Melatonin Production in Rats. Nutrients, 9.","DOI":"10.3390\/nu9040332"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Rippe, J.M., and Angelopoulos, T.J. (2016). Relationship between Added Sugars Consumption and Chronic Disease Risk Factors: Current Understanding. Nutrients, 8.","DOI":"10.3390\/nu8110697"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1056\/NEJMoa1014296","article-title":"Changes in diet and lifestyle and long-term weight gain in women and men","volume":"364","author":"Mozaffarian","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/nu6031128","article-title":"The effect of normally consumed amounts of sucrose or high fructose corn syrup on lipid profiles, body composition and related parameters in overweight\/obese subjects","volume":"6","author":"Lowndes","year":"2014","journal-title":"Nutrients"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.3390\/nu6083153","article-title":"The effects of fructose-containing sugars on weight, body composition and cardiometabolic risk factors when consumed at up to the 90th percentile population consumption level for fructose","volume":"6","author":"Lowndes","year":"2014","journal-title":"Nutrients"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3945\/ajcn.111.022533","article-title":"Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: A 6-mo randomized intervention study","volume":"95","author":"Maersk","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1056\/NEJM197608122950701","article-title":"Obesity in young men after famine exposure in utero and early infancy","volume":"295","author":"Ravelli","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1152\/physrev.00053.2003","article-title":"Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming","volume":"85","author":"McMillen","year":"2005","journal-title":"Physiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1210\/en.2009-1088","article-title":"Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet","volume":"151","author":"Drake","year":"2010","journal-title":"Endocrinology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/en.2011-1601","article-title":"Prenatal dexamethasone exposure potentiates diet-induced hepatosteatosis and decreases plasma IGF-I in a sex-specific fashion","volume":"153","author":"Carbone","year":"2012","journal-title":"Endocrinology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1038\/s41598-017-10642-1","article-title":"Prolonged fasting elicits increased hepatic triglyceride accumulation in rats born to dexamethasone-treated mothers","volume":"7","author":"Murata","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1471-0528.1990.tb01711.x","article-title":"The effects of corticosteroid administration before preterm delivery: An overview of the evidence from controlled trials","volume":"97","author":"Crowley","year":"1990","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0021-9258(18)91372-4","article-title":"Effects of Dexamethasone and 2-deoxy-D-glucose on fructose and gluctose metabolism by incubated adipose tissue","volume":"239","author":"Fain","year":"1964","journal-title":"J. Biol. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1152\/ajplegacy.1976.230.1.163","article-title":"Carbohydrate metabolism in perfused livers of adrenalectomized and steroid-replaced rats","volume":"230","author":"Exton","year":"1976","journal-title":"Am. J. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1172\/JCI106919","article-title":"Effect of carbohydrate and corticosteroids on activity of \u03b1-glucosidases in intestine of the infant rat","volume":"51","author":"Lebenthal","year":"1972","journal-title":"J. Clin. Investig."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jnutbio.2007.01.004","article-title":"Dexamethasone and GLP-2 administered to rat dams during pregnancy and lactation have late effects on intestinal sugar transport in their postweaning offspring","volume":"19","author":"Drozdowski","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1210\/en.2007-0906","article-title":"Dexamethasone sensitizes the neonatal intestine to fructose induction of intestinal fructose transporter (Slc2A5) function","volume":"149","author":"Douard","year":"2008","journal-title":"Endocrinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"R1146","DOI":"10.1152\/ajpregu.00513.2013","article-title":"Selective regulation of hepatic lipid metabolism by the AMP-activated protein kinase pathway in late-pregnant rats","volume":"307","author":"Rodrigues","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1042\/bj1600447","article-title":"The maximum activities of hexokinase, phosphorylase, phosphofructokinase, glycerol phosphate dehydrogenases, lactate dehydrogenase, octopine dehydrogenase, phosphoenolpyruvate carboxykinase, nucleoside diphosphatekinase, glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in muscles from marine invertebrates","volume":"160","author":"Zammit","year":"1976","journal-title":"Biochem. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/bj1030391","article-title":"The activities of fructose 1,6-diphosphatase, phosphofructokinase and phosphoenolpyruvate carboxykinase in white muscle and red muscle","volume":"103","author":"Opie","year":"1967","journal-title":"Biochem. J."},{"key":"ref_29","unstructured":"Bergmeyer, H.U. (1963). Methods of Enzymatic Analysis, Verlag Chemie."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1042\/bj1540689","article-title":"Activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates","volume":"154","author":"Alp","year":"1976","journal-title":"Biochem. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0003-2697(72)90061-9","article-title":"A rapid spectrophotometric assay for carnitine palmitoyltransferase","volume":"50","author":"Bieber","year":"1972","journal-title":"Anal. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Geidl-Flueck, B., and Gerber, P.A. (2017). Insights into the Hexose Liver Metabolism-Glucose versus Fructose. Nutrients, 9.","DOI":"10.3390\/nu9091026"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Low, W.S., Cornfield, T., Charlton, C.A., Tomlinson, J.W., and Hodson, L. (2018). Sex Differences in Hepatic De Novo Lipogenesis with Acute Fructose Feeding. Nutrients, 10.","DOI":"10.3390\/nu10091263"},{"key":"ref_34","first-page":"E930","article-title":"Age-related changes in body composition are associated with hepatic insulin resistance in conscious rats","volume":"270","author":"Barzilai","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/BF00495727","article-title":"NADP-dependent dehydrogenases in rat liver parenchyma. II. Comparison of qualitative and quantitative G6PDH distribution patterns with particular reference to sex differences","volume":"60","author":"Teutsch","year":"1979","journal-title":"Histochemistry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"G592","DOI":"10.1152\/ajpgi.00063.2005","article-title":"Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production","volume":"289","author":"Grefhorst","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/BJ20100336","article-title":"The identification of the SNARE complex required for the fusion of VLDL-transport vesicle with hepatic cis-Golgi","volume":"429","author":"Siddiqi","year":"2010","journal-title":"Biochem. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12982","DOI":"10.1073\/pnas.0703778104","article-title":"Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes","volume":"104","author":"Rozema","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1194\/jlr.M012872","article-title":"siRNA-induced liver ApoB knockdown lowers serum LDL-cholesterol in a mouse model with human-like serum lipids","volume":"52","author":"Peterson","year":"2011","journal-title":"J. Lipid Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s11745-011-3596-3","article-title":"ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5)","volume":"46","author":"Ason","year":"2011","journal-title":"Lipids"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1194\/jlr.M300275-JLR200","article-title":"Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele","volume":"45","author":"Chen","year":"2004","journal-title":"J. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1194\/jlr.M800248-JLR200","article-title":"Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice","volume":"49","author":"Minehira","year":"2008","journal-title":"J. Lipid Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1530\/eje.0.1450529","article-title":"Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring","volume":"145","author":"Sugden","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/en.2013-1153","article-title":"Postnatal dietary omega-3 fatty acid supplementation rescues glucocorticoid-programmed adiposity, hypertension, and hyperlipidemia in male rat offspring raised on a high-fat diet","volume":"154","author":"Zulkafli","year":"2013","journal-title":"Endocrinology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/en.2005-0748","article-title":"Prevention of programmed hyperleptinemia and hypertension by postnatal dietary omega-3 fatty acids","volume":"147","author":"Wyrwoll","year":"2006","journal-title":"Endocrinology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.15252\/embj.201695081","article-title":"Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy","volume":"36","author":"Kimura","year":"2017","journal-title":"EMBO J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1172\/JCI8814","article-title":"CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis","volume":"105","author":"Leclercq","year":"2000","journal-title":"J. Clin. Investig."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"G55","DOI":"10.1152\/ajpgi.00360.2005","article-title":"Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline-deficient medium","volume":"291","author":"Sahai","year":"2006","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jhep.2010.07.006","article-title":"Autophagy in liver diseases","volume":"53","author":"Rautou","year":"2010","journal-title":"J. Hepatol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"24131","DOI":"10.1074\/jbc.M702824200","article-title":"p62\/SQSTM1 binds directly to Atg8\/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy","volume":"282","author":"Pankiv","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.33549\/physiolres.932285","article-title":"Autophagy-lysosomal pathway is involved in lipid degradation in rat liver","volume":"61","author":"Skop","year":"2012","journal-title":"Physiol. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1179","DOI":"10.1038\/cddis.2014.162","article-title":"Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD","volume":"5","author":"Mayoral","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cmet.2006.01.011","article-title":"Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62","volume":"3","author":"Rodriguez","year":"2006","journal-title":"Cell Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1538\/expanim.17-0112","article-title":"Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis","volume":"67","author":"Akiyama","year":"2018","journal-title":"Exp. Anim."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jhep.2010.02.010","article-title":"Programming, metabolic syndrome, and NAFLD: The challenge of transforming a vicious cycle into a virtuous cycle","volume":"52","author":"Nobili","year":"2010","journal-title":"J. Hepatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/ijo.2012.54","article-title":"Effect of intrauterine growth retardation on liver and long-term metabolic risk","volume":"36","author":"Cianfarani","year":"2012","journal-title":"Int. J. Obes."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/9\/2114\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:17:09Z","timestamp":1760188629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/9\/2114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,5]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["nu11092114"],"URL":"https:\/\/doi.org\/10.3390\/nu11092114","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,5]]}}}