{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:21Z","timestamp":1787029161966,"version":"build-2736575974"},"reference-count":59,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Anillo ACT1416"],"award-info":[{"award-number":["Anillo ACT1416"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1150399"],"award-info":[{"award-number":["1150399"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1180525"],"award-info":[{"award-number":["1180525"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Millennium Nucleus","award":["for Cardiovascular Magnetic Resonance"],"award-info":[{"award-number":["for Cardiovascular Magnetic Resonance"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>A healthy dietary pattern and high quality nutrient intake reduce atherosclerotic cardiovascular disease risk. Red wine grape pomace (RWGP)\u2014a rich natural source of dietary fiber and antioxidants\u2014appears to be a potential functional food ingredient. The impact of a dietary supplementation with RWGP flour was evaluated in atherogenic diet-fed SR-B1 KO\/ApoER61h\/h mice, a model of lethal ischemic heart disease. SR-B1 KO\/ApoER61h\/h mice were fed with atherogenic (high fat, cholesterol, and cholic acid, HFC) diet supplemented with: (a) 20% chow (HFC-Control), (b) 20% RWGP flour (HFC-RWGP), or (c) 10% chow\/10% oat fiber (HFC-Fiber); and survival time was evaluated. In addition, SR-B1 KO\/ApoER61h\/h mice were fed for 7 or 14 days with HFC-Control or HFC-RWGP diets and plasma lipid levels, inflammation, oxidative damage, and antioxidant activity were measured. Atherosclerosis and myocardial damage were assessed by histology and magnetic resonance imaging, respectively. Supplementation with RWGP reduced premature death, changed TNF-\u03b1 and IL-10 levels, and increased plasma antioxidant activity. Moreover, decreased atheromatous aortic and brachiocephalic plaque sizes and attenuated myocardial infarction and dysfunction were also observed. These results suggest that RWGP flour intake may be used as a non-pharmacological therapeutic approach, contributing to decreased progression of atherosclerosis, reduced coronary heart disease, and improved cardiovascular outcomes.<\/jats:p>","DOI":"10.3390\/nu11092135","type":"journal-article","created":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T03:14:41Z","timestamp":1567998881000},"page":"2135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Red Wine Grape Pomace Attenuates Atherosclerosis and Myocardial Damage and Increases Survival in Association with Improved Plasma Antioxidant Activity in a Murine Model of Lethal Ischemic Heart Disease"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-5560","authenticated-orcid":false,"given":"Katherine","family":"Rivera","sequence":"first","affiliation":[{"name":"Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Salas-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2915-0171","authenticated-orcid":false,"given":"Guadalupe","family":"Echeverr\u00eda","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"},{"name":"Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3806-1610","authenticated-orcid":false,"given":"In\u00e9s","family":"Urquiaga","sequence":"additional","affiliation":[{"name":"Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Dicenta","sequence":"additional","affiliation":[{"name":"Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Druso","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"de la Cerda","sequence":"additional","affiliation":[{"name":"Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Center, Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"},{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo E.","family":"Andia","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Center, Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"},{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile"},{"name":"Department of Radiology, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Uribe","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Center, Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"},{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile"},{"name":"Department of Radiology, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristi\u00e1n","family":"Tejos","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Center, Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"},{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile"},{"name":"Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile"},{"name":"Division of Cardiovascular Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-1926","authenticated-orcid":false,"given":"Dolores","family":"Busso","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Irarr\u00e1zaval","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Center, Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"},{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile"},{"name":"Department of Electrical Engineering, School of Engineering, Pontificia Universidad Cat\u00f3lica, Santiago 7820436, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attilio","family":"Rigotti","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"},{"name":"Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica, Santiago 8330033, Chile"},{"name":"Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, 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