{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:38:47Z","timestamp":1787060327783,"version":"build-2736575974"},"reference-count":90,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH106781"],"award-info":[{"award-number":["R01MH106781"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001442"],"award-info":[{"award-number":["UL1TR001442"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Anorexia nervosa (AN) is a psychiatric disorder affected by psychological, environmental, and biological factors. Individuals with AN avoid high-fat, high-calorie diets and have shown abnormal metabolism of fatty acids (FAs), which are essential for brain and cognitive\/neuropsychiatric health. To clarify the relationship between FAs and AN, fasting and postprandial plasma FAs in AN patients and age-matched control women were analyzed via mass-spectrometry. Clinical phenotypes were assessed using Becker Anxiety Inventory and Becker Depression Inventory. AN patients and controls exhibited different FA signatures at both fasting and postprandial timepoints. Lauric acid, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and alpha-linoleic acid (ALA) were higher in AN than in controls (lauric acid: 15,081.6 \u00b1 14,970.2 vs. 8257.4 \u00b1 4740.2 pmol\/mL; ALA at fasting: 2217.7 \u00b1 1587.6 vs. 1087.9 \u00b1 821.2 pmol\/mL; ALA at postprandial: 1830.9 \u00b1 1115.6 vs. 1159.4 \u00b1 664.7 pmol\/mL. EPA: 33,788.3 \u00b1 17,487.5 vs. 22,860.6 \u00b1 12,642.4 pmol\/mL; DPA: 32,664.8 \u00b1 16,215.0 vs. 20,969.0 \u00b1 12,350.0 pmol\/mL. FDR-adjusted p-values &lt; 0.05). Food intake and AN status modified the correlations of FAs with body mass index (BMI), depression, and anxiety. Desaturases SCD-18 and D6D showed lower activities in AN compared to controls. Altered FA signature, specifically correlations between elevated n-3 FAs and worsened symptoms, illustrate metabolic underpinnings in AN. Future studies should investigate the mechanisms by which FA dysregulation, specifically elevated n-3 FAs, affects AN risk and outcome.<\/jats:p>","DOI":"10.3390\/nu11092208","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:32:41Z","timestamp":1568370761000},"page":"2208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Food-Intake Normalization of Dysregulated Fatty Acids in Women with Anorexia Nervosa"],"prefix":"10.3390","volume":"11","author":[{"given":"Nhien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of California, San Diego, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Dow","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blake","family":"Woodside","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Toronto, Toronto, ON M5T 2S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Bruce","family":"German","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Technology, University of California, Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-9169","authenticated-orcid":false,"given":"Oswald","family":"Quehenberger","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, San Diego, CA 92093, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-an Betty","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, School of Medicine University of California, San Diego, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association (2013). Feeding and eating disorders. 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