{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:46:33Z","timestamp":1791297993356,"version":"4.1.0"},"reference-count":72,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Top Institute Food and Nutrition","award":["A-1003"],"award-info":[{"award-number":["A-1003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Taurine is a sulfur containing nutrient that has been shown to protect against oxidative stress, which has been implicated in the pathophysiology leading to late graft failure after renal transplantation. We prospectively investigated whether high urinary taurine excretion, reflecting high taurine intake, is associated with low risk for development of late graft failure in renal transplant recipients (RTR). Urinary taurine excretion was measured in a longitudinal cohort of 678 stable RTR. Prospective associations were assessed using Cox regression analyses. Graft failure was defined as the start of dialysis or re-transplantation. In RTR (58% male, 53 \u00b1 13 years old, estimated glomerular filtration rate (eGFR) 45 \u00b1 19 mL\/min\/1.73 m2), urinary taurine excretion (533 (210\u2013946) \u00b5mol\/24 h) was significantly associated with serum free sulfhydryl groups (\u03b2 = 0.126; P = 0.001). During median follow-up for 5.3 (4.5\u20136.0) years, 83 (12%) patients developed graft failure. In Cox regression analyses, urinary taurine excretion was inversely associated with graft failure (hazard ratio: 0.74 (0.67\u20130.82); P &lt; 0.001). This association remained significant independent of potential confounders. High urinary taurine excretion is associated with low risk of late graft failure in RTR. Therefore, increasing taurine intake may potentially support graft survival in RTR. Further studies are warranted to determine the underlying mechanisms and the potential of taurine supplementation.<\/jats:p>","DOI":"10.3390\/nu11092212","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T10:32:41Z","timestamp":1568370761000},"page":"2212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-1627","authenticated-orcid":false,"given":"Adrian","family":"Post","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Yusof","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio W.","family":"Gomes-Neto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"van der Krogt","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"de Blaauw","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7638-0589","authenticated-orcid":false,"given":"Johanna M.","family":"Geleijnse","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Health, Wageningen University, 6708 PB Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-4487","authenticated-orcid":false,"given":"Karin","family":"Borgonjen","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Health, Wageningen University, 6708 PB Wageningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Else","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-1577","authenticated-orcid":false,"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7888-4684","authenticated-orcid":false,"given":"Gerald","family":"Rimbach","sequence":"additional","affiliation":[{"name":"Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido P.","family":"Kema","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6320-0956","authenticated-orcid":false,"given":"Dimitrios","family":"Tsikas","sequence":"additional","affiliation":[{"name":"Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Rebecca","family":"Heiner-Fokkema","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3356-6791","authenticated-orcid":false,"given":"Stephan J. L.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2165\/00003495-200868001-00002","article-title":"Trends in Kidney Transplantation Over the Past Decade","volume":"68","author":"Knoll","year":"2008","journal-title":"Drugs"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-6143.2010.03283.x","article-title":"Long-Term Renal Allograft Survival in the United States: A Critical Reappraisal","volume":"11","author":"Lamb","year":"2011","journal-title":"Am. J. Transplant."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1152\/ajprenal.00222.2006","article-title":"BOLD-MRI Assessment of Intrarenal Oxygenation and Oxidative Stress in Patients with Chronic Kidney Allograft Dysfunction","volume":"292","author":"Djamali","year":"2007","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1159\/000329320","article-title":"Reduction of Oxidative Damage Reflects a Better Kidney Transplantation Outcome","volume":"34","author":"Lanci","year":"2011","journal-title":"Am. J. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/j.ajkd.2003.09.021","article-title":"Advanced Glycation End Products and Oxidative Stress are Increased in Chronic Allograft Nephropathy","volume":"43","author":"Raj","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1034\/j.1600-6143.2002.20509.x","article-title":"Expression of Inducible and Endothelial Nitric Oxide Synthases, Formation of Peroxynitrite and Reactive Oxygen Species in Human Chronic Renal Transplant Failure","volume":"2","author":"Albrecht","year":"2002","journal-title":"Am. J. Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4062\/biomolther.2017.251","article-title":"Effects and Mechanisms of Taurine as a Therapeutic Agent","volume":"26","author":"Schaffer","year":"2018","journal-title":"Biomol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1542\/peds.83.3.433","article-title":"Taurine in Pediatric Nutrition: Review and Update","volume":"83","author":"Gaull","year":"1989","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/01.mco.0000247469.26414.55","article-title":"Is Taurine a Functional Nutrient?","volume":"9","author":"Bouckenooghe","year":"2006","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0261-5614(97)80234-8","article-title":"Taurine and Human Nutrition","volume":"16","author":"Stapleton","year":"1997","journal-title":"Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0148607190014002183","article-title":"The Taurine Content of Common Foodstuffs","volume":"14","author":"Laidlaw","year":"1990","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0378-1097(03)00611-6","article-title":"Taurine: New Implications for an Old Amino Acid","volume":"226","author":"Park","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-4615-0077-3_39","article-title":"Why is Taurine Cytoprotective?","volume":"526","author":"Schaffer","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.fct.2017.10.022","article-title":"Prophylactic Role of Taurine and its Derivatives Against Diabetes Mellitus and its Related Complications","volume":"110","author":"Sarkar","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000083245","article-title":"Protective Effects of Taurine Against Nicotine-Induced Oxidative Damage of Rat Urinary Bladder and Kidney","volume":"74","author":"Sener","year":"2005","journal-title":"Pharmacology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00726-008-0094-x","article-title":"Taurine Plays a Beneficial Role Against Cadmium-Induced Oxidative Renal Dysfunction","volume":"36","author":"Manna","year":"2009","journal-title":"Amino Acids"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1080\/08860220802272563","article-title":"The Protective Effects of Taurine Against Early Renal Injury in STZ-Induced Diabetic Rats, Correlated with Inhibition of Renal LOX-1-Mediated ICAM-1 Expression","volume":"30","author":"Wang","year":"2008","journal-title":"Ren. Fail."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/ndt\/15.8.1175","article-title":"The Protective Effect of Taurine Against Gentamicin-Induced Acute Tubular Necrosis in Rats","volume":"15","author":"Erdem","year":"2000","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jss.2007.06.014","article-title":"Donor Preconditioning with Taurine Protects Kidney Grafts from Injury After Experimental Transplantation","volume":"146","author":"Guan","year":"2008","journal-title":"J. Surg. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.2013050497","article-title":"Urinary Sulfur Metabolites Associate with a Favorable Cardiovascular Risk Profile and Survival Benefit in Renal Transplant Recipients","volume":"25","author":"Pasch","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.2215\/CJN.04590512","article-title":"Dietary Acid Load and Metabolic Acidosis in Renal Transplant Recipients","volume":"7","author":"Engberink","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1093\/ndt\/gfs069","article-title":"Sodium Intake and Blood Pressure in Renal Transplant Recipients","volume":"27","author":"Geleijnse","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_23","first-page":"303","article-title":"A Formula to Estimate the Approximate Surface Area if Height and Weight be Known 1916","volume":"5","year":"1989","journal-title":"Nutrition"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e5900","DOI":"10.1136\/bmj.e5900","article-title":"Prediction Models for Risk of Developing Type 2 Diabetes: Systematic Literature Search and Independent External Validation Study","volume":"345","author":"Abbasi","year":"2012","journal-title":"BMJ"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2017). 2. Classification and Diagnosis of Diabetes. Diabetes Care, 40, 11\u201324.","DOI":"10.2337\/dc17-S005"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/ajcn\/58.4.489","article-title":"Relative and Biomarker-Based Validity of a Food-Frequency Questionnaire Estimating Intake of Fats and Cholesterol","volume":"58","author":"Feunekes","year":"1993","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1017\/S0007114512003455","article-title":"Dietary Protein, Blood Pressure and Renal Function in Renal Transplant Recipients","volume":"109","author":"Engberink","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_28","unstructured":"National Institute for Public Health and the Environment (2013). Dutch Food Composition Table of 2006, National Institute for Public Health and the Environment."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for Total Energy Intake in Epidemiologic Studies","volume":"65","author":"Willett","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/ejh.12164","article-title":"The Chronic Kidney Disease Epidemiology Collaboration Cystatin C (CKD-EPI-CysC) Equation has an Independent Prognostic Value for overall Survival in Newly Diagnosed Patients with Symptomatic Multiple Myeloma; Is it Time to Change from MDRD to CKD-EPI-CysC Equations?","volume":"91","author":"Terpos","year":"2013","journal-title":"Eur. J. Haematol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1600-6143.2004.00515.x","article-title":"Long-Term Renal Allograft Survival: Have we made Significant Progress Or is it Time to Rethink our Analytic and Therapeutic Strategies?","volume":"4","author":"Schold","year":"2004","journal-title":"Am. J. Transplant."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1111\/j.1600-6143.2004.00558.x","article-title":"Metabolic Syndrome is Associated with Impaired Long-Term Renal Allograft Function; Not all Component Criteria Contribute Equally","volume":"4","author":"Bakker","year":"2004","journal-title":"Am. J. Transplant."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1432-2277.2012.01515.x","article-title":"Plasma Bilirubin and Late Graft Failure in Renal Transplant Recipients","volume":"25","author":"Deetman","year":"2012","journal-title":"Transpl. Int."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000487501","article-title":"The Association between Oxidative Stress Alleviation Via Sulforaphane-Induced Nrf2-HO-1\/NQO-1 Signaling Pathway Activation and Chronic Renal Allograft Dysfunction Improvement","volume":"43","author":"Lv","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11853","DOI":"10.1073\/pnas.93.21.11853","article-title":"Nitration and Inactivation of Manganese Superoxide Dismutase in Chronic Rejection of Human Renal Allografts","volume":"93","author":"Crow","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1600-6143.2004.00713.x","article-title":"Epithelial-to-Mesenchymal Transition and Oxidative Stress in Chronic Allograft Nephropathy","volume":"5","author":"Djamali","year":"2005","journal-title":"Am. J. Transplant."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1097\/01.TP.0000164319.83159.A7","article-title":"Heat Shock Protein 27 in Chronic Allograft Nephropathy: A Local Stress Response","volume":"79","author":"Djamali","year":"2005","journal-title":"Transplantation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1097\/01.TP.0000438626.91095.50","article-title":"Oxidative Stress in Kidney Transplantation: Malondialdehyde is an Early Predictive Marker of Graft Dysfunction","volume":"97","author":"Fonseca","year":"2014","journal-title":"Transplantation"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/00007890-199805270-00007","article-title":"Oxidative Stress and Lipid Abnormalities in Renal Transplant Recipients with or without Chronic Rejection","volume":"65","author":"Cristol","year":"1998","journal-title":"Transplantation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1097\/00007890-199560120-00034","article-title":"Prevention of Functional, Structural, and Molecular Changes of Chronic Rejection of Rat Renal Allografts by a Specific Macrophage Inhibitor","volume":"60","author":"Azuma","year":"1995","journal-title":"Transplantation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"8729","DOI":"10.1073\/pnas.92.19.8729","article-title":"Sequential Cytokine Dynamics in Chronic Rejection of Rat Renal Allografts: Roles for Cytokines RANTES and MCP-1","volume":"92","author":"Nadeau","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/CIRCULATIONAHA.105.000471","article-title":"Role of Endothelin-1 and Nitric Oxide Bioavailability in Transplant-Related Vascular Injury: Comparative Effects of Rapamycin and Cyclosporine","volume":"114","author":"Ramzy","year":"2006","journal-title":"Circulation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/ndt\/14.4.923","article-title":"N-Acetylcysteine Attenuates Cyclosporin-Induced Nephrotoxicity in Rats","volume":"14","author":"Tariq","year":"1999","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1523-1755.2005.00085.x","article-title":"Injury and Progressive Loss of Peritubular Capillaries in the Development of Chronic Allograft Nephropathy","volume":"67","author":"Ishii","year":"2005","journal-title":"Kidney Int."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/physrev.1992.72.1.101","article-title":"Physiological Actions of Taurine","volume":"72","author":"Huxtable","year":"1992","journal-title":"Physiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1440-1681.2004.04122.x","article-title":"Fish and Lifestyle-Related Disease Prevention: Experimental and Epidemiological Evidence for Anti-Atherogenic Potential of Taurine","volume":"31","author":"Yamori","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/978-3-319-15126-7_50","article-title":"Taurine in 24-H Urine Samples is Inversely Related to Cardiovascular Risks of Middle Aged Subjects in 50 Populations of the World","volume":"803","author":"Sagara","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1423-0127-17-S1-S6","article-title":"Taurine in Health and Diseases: Consistent Evidence from Experimental and Epidemiological Studies","volume":"17","author":"Yamori","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1007\/s00394-013-0586-7","article-title":"Oxidative Stress and Inflammation in Obesity After Taurine Supplementation: A Double-Blind, Placebo-Controlled Study","volume":"53","author":"Rosa","year":"2014","journal-title":"Eur. J. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1291\/hypres.24.453","article-title":"Distribution of Twenty-Four Hour Urinary Taurine Excretion and Association with Ischemic Heart Disease Mortality in 24 Populations of 16 Countries: Results from the WHO-CARDIAC Study","volume":"24","author":"Yamori","year":"2001","journal-title":"Hypertens. Res."},{"key":"ref_52","first-page":"365","article-title":"Efficacy of Taurine Based Compounds as Hydroxyl Radical Scavengers in Silica Induced Peroxidation","volume":"27","author":"Shi","year":"1997","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.etp.2004.08.004","article-title":"Protective Effect of Taurine Against Free Radicals Damage in the Rat Myocardium","volume":"56","author":"Hanna","year":"2004","journal-title":"Exp. Toxicol. Pathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1734-1140(10)70256-5","article-title":"Scavenging and Antioxidant Potential of Physiological Taurine Concentrations Against Different Reactive Oxygen\/Nitrogen Species","volume":"62","author":"Oliveira","year":"2010","journal-title":"Pharmacol. Rep."},{"key":"ref_55","first-page":"262","article-title":"Taurine: A Conditionally Essential Amino Acid in Humans? An Overview in Health and Disease","volume":"17","author":"Lourenco","year":"2002","journal-title":"Nutr. Hosp."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00726-011-0962-7","article-title":"Mechanism Underlying the Antioxidant Activity of Taurine: Prevention of Mitochondrial Oxidant Production","volume":"42","author":"Jong","year":"2012","journal-title":"Amino Acids"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00726-012-1414-8","article-title":"Role of Taurine in the Pathologies of MELAS and MERRF","volume":"46","author":"Schaffer","year":"2014","journal-title":"Amino Acids"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.bcp.2005.08.006","article-title":"Inhibition of LPS-Induced NO Production by Taurine Chloramine in Macrophages is Mediated Though Ras-ERK-NF-kappaB","volume":"70","author":"Kim","year":"2005","journal-title":"Biochem. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Seidel, U., Huebbe, P., and Rimbach, G. (2018). Taurine: A Regulator of Cellular Redox Homeostasis and Skeletal Muscle Function. Mol. Nutr. Food Res., e1800569.","DOI":"10.1002\/mnfr.201800569"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00726-013-1545-6","article-title":"Taurine Chloramine Produced from Taurine Under Inflammation Provides Anti-Inflammatory and Cytoprotective Effects","volume":"46","author":"Kim","year":"2014","journal-title":"Amino Acids"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00726-012-1361-4","article-title":"Taurine and Inflammatory Diseases","volume":"46","author":"Marcinkiewicz","year":"2014","journal-title":"Amino Acids"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/ajt.13940","article-title":"The Role of Neutrophils in Transplanted Organs","volume":"17","author":"Scozzi","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/0971-4065.50673","article-title":"Determination of Oxidative Stress Markers and their Importance in Early Diagnosis of Uremia-Related Complications","volume":"19","author":"Kolagal","year":"2009","journal-title":"Indian. J. Nephrol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.freeradbiomed.2016.08.024","article-title":"Serum Free Sulfhydryl Status is Associated with Patient and Graft Survival in Renal Transplant Recipients","volume":"99","author":"Frenay","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1080\/00365510410002869","article-title":"Protein Thiol Oxidation and Lipid Peroxidation in Patients with Uraemia","volume":"64","author":"Prakash","year":"2004","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"ref_66","first-page":"658","article-title":"Malondialdehyde and Sulfhydryl Groups as Biomarkers of Oxidative Stress in Patients with Systemic Lupus Erythematosus","volume":"52","author":"Perez","year":"2012","journal-title":"Rev. Bras. Reumatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/109454503323028920","article-title":"Reduced Level of Serum Thiols in Patients with a Diagnosis of Active Disease","volume":"6","author":"Banne","year":"2003","journal-title":"J. Anti Aging Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/ajt.14926","article-title":"Posttransplant Muscle Mass Measured by Urinary Creatinine Excretion Rate Predicts Long-Term Outcomes After Liver Transplantation","volume":"19","author":"Stam","year":"2019","journal-title":"Am. J. Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Post, A., Ozyilmaz, A., Westerhuis, R., Ipema, K.J.R., Bakker, S.J.L., and Franssen, C.F.M. (2018). Complementary Biomarker Assessment of Components Absorbed from Diet and Creatinine Excretion Rate Reflecting Muscle Mass in Dialysis Patients. Nutrients, 10.","DOI":"10.3390\/nu10121827"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2174\/1389203718666161122113609","article-title":"The Beneficial Effects of Taurine to Counteract Sarcopenia","volume":"19","author":"Scicchitano","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1748-1716.2006.01573.x","article-title":"The Taurine Transporter: Mechanisms of Regulation","volume":"187","author":"Han","year":"2006","journal-title":"Acta Physiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/jn\/105.9.1206","article-title":"Metabolism of [35S]Taurine","volume":"105","author":"Sturman","year":"1975","journal-title":"Man. J. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/9\/2212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:19:50Z","timestamp":1760188790000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/9\/2212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,13]]},"references-count":72,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2019,9]]}},"alternative-id":["nu11092212"],"URL":"https:\/\/doi.org\/10.3390\/nu11092212","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,13]]}}}