{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:35:11Z","timestamp":1771918511758,"version":"3.50.1"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T00:00:00Z","timestamp":1568764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Admitted bedridden older patients are at risk of the development of sarcopenia during hospital stay (incident sarcopenia). The objective of this study was to assess the factors associated with sarcopenia (incident and chronic) and its impact on mortality in older people with hip fracture. Methods: A multicenter, pragmatic, prospective observational study was designed. Older subjects with hip fracture admitted to two rehabilitation units were included. Sarcopenia was assessed at admission and at discharge according to the revised EWGSOP (European Working Group on Sarcopenia in Older People) consensus definition. The mortality was evaluated after 7 years of follow-up. Results: A total of 187 subjects (73.8% women) age 85.2 \u00b1 6.3 years were included. Risk factors associated to incident and chronic sarcopenia were undernutrition (body mass index\u2014BMI and Mini Nutritional Assessment\u2212Short Form\u2014MNA-SF), hand-grip strength and skeletal muscle index. During follow-up 114 patients died (60.5% sarcopenic vs. 39.5% non-sarcopenic, p = 0.001). Cox regression analyses showed that factors associated to increased risk of mortality were sarcopenia (HR: 1.67, 95% CI 1.11\u20132.51) and low hand-grip strength (HR: 1.76, 95% CI 1.08\u20132.88). Conclusions: Older patients with undernutrition have a higher risk of developing sarcopenia during hospital stay, and sarcopenic patients have almost two times more risk of mortality than non-sarcopenic patients during follow-up after hip fracture.<\/jats:p>","DOI":"10.3390\/nu11092243","type":"journal-article","created":{"date-parts":[[2019,9,18]],"date-time":"2019-09-18T11:01:15Z","timestamp":1568804475000},"page":"2243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Factors Associated with Sarcopenia and 7-Year Mortality in Very Old Patients with Hip Fracture Admitted to Rehabilitation Units: A Pragmatic Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-1556","authenticated-orcid":false,"given":"Vincenzo","family":"Malafarina","sequence":"first","affiliation":[{"name":"Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Department of Geriatrics, Complejo Hospitalario de Navarra, Calle de Irunlarrea 3, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Concetta","family":"Malafarina","sequence":"additional","affiliation":[{"name":"Department of Radiology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arantzazu","family":"Biain Ugarte","sequence":"additional","affiliation":[{"name":"Nursing Department, Hospitalizaci\u00f3n a Domicilio, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5218-6941","authenticated-orcid":false,"given":"J. Alfredo","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"CIBERobn, Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Centre for Nutrition Research, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6475-5387","authenticated-orcid":false,"given":"Itziar","family":"Abete Go\u00f1i","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"CIBERobn, Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Centre for Nutrition Research, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3926-0892","authenticated-orcid":false,"given":"M. Angeles","family":"Zulet","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Food Science and Physiology, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"CIBERobn, Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Centre for Nutrition Research, School of Pharmacy and Nutrition, Universidad de Navarra, 31008 Pamplona, Spain"},{"name":"Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jamda.2018.11.020","article-title":"Understanding and Addressing Muscle Strength, Mass, and Function in Older Persons","volume":"20","author":"Sloane","year":"2019","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jamda.2016.06.001","article-title":"Sarcopenia Is Recognized as an Independent Condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) Code","volume":"17","author":"Cao","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/jcsm.12147","article-title":"Welcome to the ICD-10 code for sarcopenia","volume":"7","author":"Anker","year":"2016","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1007\/s00198-017-4151-8","article-title":"Osteosarcopenia: Where bone, muscle, and fat collide","volume":"28","author":"Hirschfeld","year":"2017","journal-title":"Osteoporos Int."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mathieu, S.-V., Fischer, K., Dawson-Hughes, B., Freystaetter, G., Beuschlein, F., Schietzel, S., Egli, A., and Bischoff-Ferrari, H. (2018). Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women. Nutrients, 10.","DOI":"10.3390\/nu10121826"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s10067-015-2943-9","article-title":"The role of sarcopenia in the risk of osteoporotic hip fracture","volume":"34","author":"Oliveira","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.maturitas.2016.09.007","article-title":"A one-year proprioceptive exercise programme reduces the incidence of falls in community-dwelling elderly people: A before\u2013after non-randomised intervention study","volume":"94","author":"Malafarina","year":"2016","journal-title":"Maturitas"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jamda.2014.09.009","article-title":"Factors associated with short-term functional recovery in elderly people with a hip fracture. Influence of cognitive impairment","volume":"16","author":"Malafarina","year":"2015","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Steihaug, O.M., Gjesdal, C.G., Bogen, B., Kristoffersen, M.H., Lien, G., Hufthammer, K.O., and Ranhoff, A.H. (2018). Does sarcopenia predict change in mobility after hip fracture? a multicenter observational study with one-year follow-up. BMC Geriatr., 18.","DOI":"10.1186\/s12877-018-0755-x"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.maturitas.2016.04.005","article-title":"Factors associated to institutionalization and mortality over three years, in elderly people with a hip fracture-An observational study","volume":"89","author":"Malafarina","year":"2016","journal-title":"Maturitas"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.clnu.2017.08.016","article-title":"Does nutrition play a role in the prevention and management of sarcopenia?","volume":"37","author":"Robinson","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.jamda.2016.04.019","article-title":"Skeletal Muscle Regulates Metabolism via Interorgan Crosstalk: Roles in Health and Disease","volume":"17","author":"Campos","year":"2016","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Agostini, D., Zeppa, S.D., Lucertini, F., Annibalini, G., Gervasi, M., Marini, C.F., Piccoli, G., Stocchi, V., Barbieri, E., and Sestili, P. (2018). Muscle and Bone Health in Postmenopausal Women: Role of Protein and Vitamin D Supplementation Combined with Exercise Training. Nutrients, 10.","DOI":"10.3390\/nu10081103"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.maturitas.2017.04.010","article-title":"Effectiveness of nutritional supplementation on sarcopenia and recovery in hip fracture patients. A multi-centre randomized trial","volume":"101","author":"Malafarina","year":"2017","journal-title":"Maturitas"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Malafarina, V., Reginster, J.-Y., Cabrerizo, S., Bruy\u00e8re, O., Kanis, J.A., Martinez, J.A., and Zulet, M.A. (2018). Nutritional Status and Nutritional Treatment Are Related to Outcomes and Mortality in Older Adults with Hip Fracture. Nutrients, 10.","DOI":"10.3390\/nu10050555"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/ggi.12590","article-title":"Prevalence of sarcopenia in acute hip fracture patients and its influence on short-term clinical outcome","volume":"16","author":"Gotor","year":"2016","journal-title":"Geriatr. Gerontol. Int."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Steihaug, O.M., Gram Gjesdal, C., Bogen, B., Kristoffersen, M.H., Lien, G., and Ranhoff, A.H. (2017). Sarcopenia in patients with hip fracture: A multicenter cross-sectional study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184780"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00198-017-3929-z","article-title":"The association between sarcopenia and functional outcomes among older patients with hip fracture undergoing in-hospital rehabilitation","volume":"28","author":"Landi","year":"2017","journal-title":"Osteoporos Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.clnu.2017.09.009","article-title":"Prevalence of sarcopenia and its association with activities of daily living and dysphagia in convalescent rehabilitation ward inpatients","volume":"37","author":"Yoshimura","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/gerona\/glu034","article-title":"Association of sarcopenia with short- and long-term mortality in older adults admitted to acute care wards: Results from the CRIME study","volume":"69","author":"Vetrano","year":"2014","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.clnu.2014.08.015","article-title":"Sarcopenia and malnutrition in acutely ill hospitalized elderly: Prevalence and outcomes","volume":"34","author":"Cerri","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.clnu.2013.01.010","article-title":"Sarcopenia: Prevalence and prognostic significance in hospitalized patients","volume":"32","author":"Gariballa","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jcsm.12163","article-title":"Sarcopenia predicts readmission and mortality in elderly patients in acute care wards: A prospective study","volume":"8","author":"Yang","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1111\/j.1532-5415.2008.02015.x","article-title":"Recruitment and retention of older adults in aging research","volume":"56","author":"Mody","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMp1103502","article-title":"Pragmatic trials\u2014Guides to better patient care?","volume":"364","author":"Ware","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jamda.2018.12.021","article-title":"Making Pragmatic Trials Pragmatic in Post-acute and Long-term Care Settings","volume":"20","author":"Zimmerman","year":"2019","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jclinepi.2008.12.011","article-title":"A pragmatic-explanatory continuum indicator summary (PRECIS): A tool to help trial designers","volume":"62","author":"Thorpe","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/ageing\/afr051","article-title":"A review of the measurement of grip strength in clinical and epidemiological studies: Towards a standardised approach","volume":"40","author":"Roberts","year":"2011","journal-title":"Age Ageing"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/MCO.0000000000000387","article-title":"Assessment of adult malnutrition and prognosis with bioelectrical impedance analysis: Phase angle and impedance ratio","volume":"20","author":"Lukaski","year":"2017","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.archger.2009.12.002","article-title":"Bioelectric impedance phase angle is associated with hospital mortality of geriatric patients","volume":"51","author":"Wirth","year":"2010","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.clnu.2014.07.010","article-title":"Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults","volume":"34","author":"Sergi","year":"2015","journal-title":"Clin. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s12603-016-0686-1","article-title":"Identifying Low Muscle Mass in Patients with Hip Fracture: Validation of Biolectrical Impedance Analysis and Anthropometry Compared to Dual Energy X-ray Absorptiometry","volume":"20","author":"Steihaug","year":"2016","journal-title":"J. Nutr. Health Aging"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s12603-009-0214-7","article-title":"Validation of the Mini Nutritional Assessment short-form (MNA-SF): A practical tool for identification of nutritional status","volume":"13","author":"Kaiser","year":"2009","journal-title":"J. Nutr. Health Aging"},{"key":"ref_35","first-page":"61","article-title":"Functional Evaluation: The Barthel Index","volume":"14","author":"Mahoney","year":"1965","journal-title":"Md. State Med. J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J. Psychiatr. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1073\/pnas.0501559102","article-title":"Decline in skeletal muscle mitochondrial function with aging in humans","volume":"102","author":"Short","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/jcsm.12224","article-title":"The incidence of sarcopenia among hospitalized older patients: Results from the Glisten study","volume":"8","author":"Martone","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s12603-011-0108-3","article-title":"Prevalence of sarcopenia in healthy community-dwelling elderly in an urban area of Barcelona (Spain)","volume":"16","author":"Masanes","year":"2012","journal-title":"J. Nutr. Health Aging"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1007\/s00394-012-0437-y","article-title":"Association of anorexia with sarcopenia in a community-dwelling elderly population: Results from the ilSIRENTE study","volume":"52","author":"Landi","year":"2013","journal-title":"Eur. J. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.maturitas.2012.10.014","article-title":"\u201cSarcobesity\u201d: A metabolic conundrum","volume":"74","author":"Parr","year":"2013","journal-title":"Maturitas"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.maturitas.2012.09.014","article-title":"Fat mass influence on bone mass is mediated by the independent association between lean mass and bone mass among elderly women: A cross-sectional study","volume":"74","author":"Ara","year":"2013","journal-title":"Maturitas"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clnu.2018.05.024","article-title":"ESPEN guideline on clinical nutrition and hydration in geriatrics","volume":"38","author":"Volkert","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.maturitas.2018.03.010","article-title":"Traditional body mass index cut-offs in older people: Time for a rethink with altered fat distribution, sarcopenia and shrinking height","volume":"113","year":"2018","journal-title":"Maturitas"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Del Mar Bibiloni, M., Karam, J., Bouzas, C., Aparicio-Ugarriza, R., Pedrero-Chamizo, R., Sureda, A., Gonz\u00e1lez-Gross, M., and Tur, J. (2018). Association between Physical Condition and Body Composition, Nutrient Intake, Sociodemographic Characteristics, and Lifestyle Habits in Older Spanish Adults. Nutrients, 10.","DOI":"10.3390\/nu10111608"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.maturitas.2018.11.013","article-title":"A translational approach for the clinical application of recently updated definitions of malnutrition (GLIM) and sarcopenia (EWGSOP2)","volume":"122","author":"Annweiler","year":"2019","journal-title":"Maturitas"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Landi, F., Camprubi-Robles, M., Bear, D.E., Cederholm, T., Malafarina, V., Welch, A.A., and Cruz-Jentoft, A.J. (2018). Muscle loss: The new malnutrition challenge in clinical practice. Clin. Nutr.","DOI":"10.1016\/j.clnu.2018.11.021"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.maturitas.2013.01.016","article-title":"The anorexia of ageing: Physiopathology, prevalence, associated comorbidity and mortality. A systematic review","volume":"74","author":"Malafarina","year":"2013","journal-title":"Maturitas"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jamda.2012.08.001","article-title":"Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: A systematic review","volume":"14","author":"Malafarina","year":"2013","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Sayer","year":"2019","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.maturitas.2018.11.006","article-title":"Changes in frailty status in a community-dwelling cohort of older adults: The VERISA\u00daDE study","volume":"119","author":"Maseda","year":"2019","journal-title":"Maturitas"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Granic, A., Mendon\u00e7a, N., Hill, T., Jagger, C., Stevenson, E., Mathers, J., and Sayer, A. (2018). Nutrition in the Very Old. Nutrients, 10.","DOI":"10.3390\/nu10030269"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.maturitas.2018.04.001","article-title":"Optimizing nutrition in older people","volume":"112","author":"Clegg","year":"2018","journal-title":"Maturitas"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s12603-018-0995-7","article-title":"Role of Oral Nutritional Supplements Enriched with B-hydroxy-B-Methylbutyrate in Maintaining Muscle Function and Improving Clinical Outcomes in Various Clinical Settings","volume":"22","author":"Pereira","year":"2018","journal-title":"J. Nutr. Health Aging"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Trouwborst, I., Verreijen, A., Memelink, R., Massanet, P., Boirie, Y., Weijs, P., and Tieland, M. (2018). Exercise and nutrition strategies to counteract sarcopenic obesity. Nutrients, 10.","DOI":"10.3390\/nu10050605"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Aquilani, R., Zuccarelli, G., Condino, A., Catani, M., Rutili, C., Del Vecchio, C., Pisano, P., Verri, M., Iadarola, P., and Viglio, S. (2017). Despite Inflammation, Supplemented Essential Amino Acids May Improve Circulating Levels of Albumin and Haemoglobin in Patients after Hip Fractures. Nutrients, 9.","DOI":"10.3390\/nu9060637"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.maturitas.2018.07.007","article-title":"Effect of exercise alone or combined with dietary supplements on anthropometric and physical performance measures in community-dwelling elderly people with sarcopenic obesity: A meta-analysis of randomized controlled trials","volume":"116","author":"Hernandez","year":"2018","journal-title":"Maturitas"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.maturitas.2018.02.005","article-title":"Exercise alone or combined with dietary supplements for sarcopenic obesity in community-dwelling older people: A systematic review of randomized controlled trials","volume":"110","author":"Achalandabaso","year":"2018","journal-title":"Maturitas"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1093\/ajcn\/82.4.872","article-title":"Weight change and the conservation of lean mass in old age: The Health, Aging and Body Composition Study","volume":"82","author":"Newman","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1016\/j.archger.2012.05.002","article-title":"Sarcopenia is more prevalent in men than in women after hip fracture: A cross-sectional study of 591 inpatients","volume":"55","author":"Castiglioni","year":"2012","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s11357-015-9860-3","article-title":"Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults","volume":"37","author":"Tay","year":"2015","journal-title":"Age (Omaha)"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.amjmed.2014.02.004","article-title":"Predictive parameters of accelerated muscle loss in men-MINOS study","volume":"127","author":"Renoud","year":"2014","journal-title":"Am. J. Med."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12603-018-1134-1","article-title":"Sarcopenia is Related to Mortality in the Acutely Hospitalized Geriatric Patient","volume":"23","author":"Sipers","year":"2019","journal-title":"J. Nutr. Health Aging"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/ageing\/afx087","article-title":"Initial level and rate of change in grip strength predict all-cause mortality in very old adults","volume":"46","author":"Granic","year":"2017","journal-title":"Age Ageing"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/ageing\/afw222","article-title":"Mortality in the Hertfordshire Ageing Study: Association with level and loss of hand grip strength in later life","volume":"46","author":"Syddall","year":"2017","journal-title":"Age Ageing"},{"key":"ref_67","first-page":"690","article-title":"The pattern of recovery of ambulation after hip fracture differs with age in elderly patients","volume":"67","year":"2012","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"464.e9","DOI":"10.1016\/j.jamda.2016.02.001","article-title":"Effects of Geriatric Interdisciplinary Home Rehabilitation on Walking Ability and Length of Hospital Stay After Hip Fracture: A Randomized Controlled Trial","volume":"17","author":"Karlsson","year":"2016","journal-title":"J. Am. Med. Dir. 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