{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:18:41Z","timestamp":1792167521737,"version":"4.4.0"},"reference-count":57,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>One third of U.S. adults report short sleep (&lt;7 h), which has been linked to negative health outcomes. Inadequate intake of micronutrients across the U.S. adult population has been reported, and a relationship between sleep conditions and micronutrient intake is emerging. This cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES 2005\u20132016) (n = 26,211) showed that participants with short sleep duration had a lower usual intake (Food + Supplements) of calcium, magnesium, and vitamin D in all adults aged 19+ years, and vitamin K in adults aged 19\u201350 years, even after adjusting for covariates. In addition, participants reporting short sleep had a higher percentage of individuals with intake lower than the estimated average requirement (EAR) across multiple nutrients. Age and gender differences were observed in the prevalence of inadequate intake across multiple nutrients. Adults aged 51\u201399 years with short sleep duration had inadequate intake with respect to more nutrients. In females there was an association between short sleep and a higher prevalence of inadequate intake (Food + Spp) for calcium, magnesium, and vitamins A, C, D, E, and K (above adequate intake). Conversely, males reporting short sleep only had an inadequate intake of vitamin D. Overall, we demonstrate that short sleep is associated with increased nutrient inadequacy, emphasizing the possible need for dietary supplementation.<\/jats:p>","DOI":"10.3390\/nu11102335","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T11:11:16Z","timestamp":1569928276000},"page":"2335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Micronutrient Inadequacy in Short Sleep: Analysis of the NHANES 2005\u20132016"],"prefix":"10.3390","volume":"11","author":[{"given":"Chioma J.","family":"Ikonte","sequence":"first","affiliation":[{"name":"Science &amp; Technology, Pharmavite LLC, West Hills, CA 91304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Mun","sequence":"additional","affiliation":[{"name":"Science &amp; Technology, Pharmavite LLC, West Hills, CA 91304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carroll A.","family":"Reider","sequence":"additional","affiliation":[{"name":"Science &amp; Technology, Pharmavite LLC, West Hills, CA 91304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan W.","family":"Grant","sequence":"additional","affiliation":[{"name":"Science &amp; Technology, Pharmavite LLC, West Hills, CA 91304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Hazels","family":"Mitmesser","sequence":"additional","affiliation":[{"name":"Science &amp; Technology, Pharmavite LLC, West Hills, CA 91304, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"ref_1","first-page":"11","article-title":"Why Sleep Matters-The Economic Costs of Insufficient Sleep: A Cross-Country Comparative Analysis","volume":"6","author":"Hafner","year":"2017","journal-title":"Rand Health Q."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.sleh.2014.12.010","article-title":"National Sleep Foundation\u2019s sleep time duration recommendations: Methodology and results summary","volume":"1","author":"Hirshkowitz","year":"2015","journal-title":"Sleep Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"591","DOI":"10.5664\/jcsm.4758","article-title":"Recommended Amount of Sleep for a Healthy Adult: A Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society","volume":"11","author":"Watson","year":"2015","journal-title":"J. Clin. Sleep Med."},{"key":"ref_4","unstructured":"Centers for Disease Control and Prevention (2018, November 15). NHANES-About the National Health and Nutrition Examination Survey, Available online: https:\/\/www.cdc.gov\/nchs\/nhanes\/about_nhanes.htm."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1093\/eurheartj\/ehr007","article-title":"Sleep duration predicts cardiovascular outcomes: A systematic review and meta-analysis of prospective studies","volume":"32","author":"Cappuccio","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1001\/archinternmed.2009.119","article-title":"Association between sleep and blood pressure in midlife: The CARDIA sleep study","volume":"169","author":"Knutson","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.beem.2010.08.014","article-title":"Sleep loss and inflammation","volume":"24","author":"Mullington","year":"2010","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1007\/s00125-007-0786-x","article-title":"Association of sleep duration with type 2 diabetes and impaired glucose tolerance","volume":"50","author":"Chaput","year":"2007","journal-title":"Diabetologia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.5665\/sleep.3104","article-title":"Longitudinal associations between objective sleep and lipids: The CARDIA study","volume":"36","author":"Petrov","year":"2013","journal-title":"Sleep"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/HJH.0b013e328335d076","article-title":"A population-based study of reduced sleep duration and hypertension: The strongest association may be in premenopausal women","volume":"28","author":"Stranges","year":"2010","journal-title":"J. Hypertens."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/sleep\/31.5.619","article-title":"Meta-analysis of short sleep duration and obesity in children and adults","volume":"31","author":"Cappuccio","year":"2008","journal-title":"Sleep"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/oby.2007.118","article-title":"Short sleep duration and weight gain: A systematic review","volume":"16","author":"Patel","year":"2008","journal-title":"Obesity"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.smrv.2008.03.001","article-title":"Is sleep duration related to obesity? A critical review of the epidemiological evidence","volume":"12","author":"Marshall","year":"2008","journal-title":"Sleep Med. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1093\/sleep\/33.5.585","article-title":"Sleep duration and all-cause mortality: A systematic review and meta-analysis of prospective studies","volume":"33","author":"Cappuccio","year":"2010","journal-title":"Sleep"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.appet.2013.01.004","article-title":"Dietary nutrients associated with short and long sleep duration. Data from a nationally representative sample","volume":"64","author":"Grandner","year":"2013","journal-title":"Appetite"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Blumberg, J.B., Frei, B.B., Fulgoni, V.L., Weaver, C.M., and Zeisel, S.H. (2017). Impact of Frequency of Multi-Vitamin\/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults. Nutrients, 9.","DOI":"10.3390\/nu9080849"},{"key":"ref_17","unstructured":"US Department of Health and Human Services (2019, March 04). 2015\u20132020 Dietary Guidelines for Americans, Available online: https:\/\/health.gov\/dietaryguidelines\/2015\/resources\/2015-2020_Dietary_Guidelines.pdf."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.profoo.2013.04.016","article-title":"USDA Food and Nutrient Database for Dietary Studies (FNDDS), 5.0","volume":"2","author":"Montville","year":"2013","journal-title":"Procedia Food Sci."},{"key":"ref_19","unstructured":"United States Department of Agriculture, Agricultural Research Service (2018, November 18). USDA Food and Nutrient Database for Dietary Studies 2011\u20132012, Available online: https:\/\/www.ars.usda.gov\/northeast-area\/beltsville-md-bhnrc\/beltsville-human-nutrition-research-center\/food-surveys-research-group\/."},{"key":"ref_20","unstructured":"United States Department of Agriculture (2018, November 18). US Department of Agriculture National Agriculture Library: National Nutrient Database for Standard Reference, Available online: http:\/\/ndb.nal.usda.gov\/."},{"key":"ref_21","unstructured":"Centers for Disease Control and Prevention, and National Center for Health Statistics (2018, November 18). Questionnaires, Datasets and Related Documentation, NHANES, Available online: https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1002\/sim.4063","article-title":"A mixed-effects model approach for estimating the distribution of usual intake of nutrients: The NCI method","volume":"29","author":"Tooze","year":"2010","journal-title":"Stat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Bird, J.K., Murphy, R.A., Ciappio, E.D., and McBurney, M.I. (2017). Risk of Deficiency in Multiple Concurrent Micronutrients in Children and Adults in the United States. Nutrients, 9.","DOI":"10.3390\/nu9070655"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3945\/jn.111.142257","article-title":"Foods, fortificants, and supplements: Where do Americans get their nutrients?","volume":"141","author":"Fulgoni","year":"2011","journal-title":"J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5665\/sleep.4408","article-title":"Vitamin D and actigraphic sleep outcomes in older community-dwelling men: The MrOS sleep study","volume":"38","author":"Massa","year":"2015","journal-title":"Sleep"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Piovezan, R.D., Hirotsu, C., Feres, M.C., Cintra, F.D., Andersen, M.L., Tufik, S., and Poyares, D. (2017). Obstructive sleep apnea and objective short sleep duration are independently associated with the risk of serum vitamin D deficiency. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180901"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.5665\/sleep.4914","article-title":"25-Hydroxyvitamin D Concentration and Sleep Duration and Continuity: Multi-Ethnic Study of Atherosclerosis","volume":"38","author":"Bertisch","year":"2015","journal-title":"Sleep"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gao, Q., Kou, T., Zhuang, B., Ren, Y., Dong, X., and Wang, Q. (2018). The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis. Nutrients, 10.","DOI":"10.3390\/nu10101395"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.autrev.2013.02.004","article-title":"Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence","volume":"12","author":"Pludowski","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1126\/science.6977846","article-title":"Brain target sites for 1,25-dihydroxyvitamin D3","volume":"215","author":"Stumpf","year":"1982","journal-title":"Science"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1043-2760(01)00547-1","article-title":"New clues about vitamin D functions in the nervous system","volume":"13","author":"Garcion","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/0748730414549239","article-title":"A Role for 1\u03b1,25-Dihydroxyvitamin D3 in the Expression of Circadian Genes","volume":"29","author":"Scott","year":"2014","journal-title":"J. Biol. Rhythm."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.smrv.2013.07.001","article-title":"The link between vitamin D metabolism and sleep medicine","volume":"18","author":"McCarty","year":"2014","journal-title":"Sleep Med. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000118988","article-title":"Effects of a magnesium-deficient diet on sleep organization in rats","volume":"27","author":"Depoortere","year":"1993","journal-title":"Neuropsychobiology"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Cao, Y., Zhen, S., Taylor, A.W., Appleton, S., Atlantis, E., and Shi, Z. (2018). Magnesium Intake and Sleep Disorder Symptoms: Findings from the Jiangsu Nutrition Study of Chinese Adults at Five-Year Follow-Up. Nutrients, 10.","DOI":"10.3390\/nu10101354"},{"key":"ref_36","first-page":"1161","article-title":"The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial","volume":"17","author":"Abbasi","year":"2012","journal-title":"J. Res. Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nature17407","article-title":"Daily magnesium fluxes regulate cellular timekeeping and energy balance","volume":"532","author":"Feeney","year":"2016","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0748730419851655","article-title":"Magnesium Regulates the Circadian Oscillator in Cyanobacteria","volume":"34","author":"Jeong","year":"2019","journal-title":"J. Biol. Rhythm."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Peuhkuri, K., Sihvola, N., and Korpela, R. (2012). Dietary factors and fluctuating levels of melatonin. Food Nutr. Res., 56.","DOI":"10.3402\/fnr.v56i0.17252"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/jsr.12084","article-title":"Sleep symptoms associated with intake of specific dietary nutrients","volume":"23","author":"Grandner","year":"2014","journal-title":"J. Sleep Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/aje\/154.12.1113","article-title":"Which plasma antioxidants are most related to fruit and vegetable consumption?","volume":"154","author":"Block","year":"2001","journal-title":"Am. J. Epidemiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.ypmed.2007.11.008","article-title":"Sleep duration and obesity-related risk factors in the rural Midwest","volume":"46","author":"Stamatakis","year":"2008","journal-title":"Prev. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e020810","DOI":"10.1136\/bmjopen-2017-020810","article-title":"The relationship between sleep duration and fruit\/vegetable intakes in UK adults: A cross-sectional study from the National Diet and Nutrition Survey","volume":"8","author":"Noorwali","year":"2018","journal-title":"BMJ Open"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbr.2011.09.017","article-title":"The neuroprotective effect of vitamin E on chronic sleep deprivation-induced memory impairment: The role of oxidative stress","volume":"226","author":"Alzoubi","year":"2012","journal-title":"Behav. Brain Res."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Beydoun, M.A., Gamaldo, A.A., Canas, J.A., Beydoun, H.A., Shah, M.T., McNeely, J.M., and Zonderman, A.B. (2014). Serum nutritional biomarkers and their associations with sleep among US adults in recent national surveys. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0103490"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.1523\/JNEUROSCI.1883-16.2016","article-title":"A novel role for the visual retinoid cycle in melanopsin chromophore regeneration","volume":"36","author":"Sonoda","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/jnc.12620","article-title":"The rhythm of retinoids in the brain","volume":"129","author":"Ransom","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1161\/01.HYP.8.10.843","article-title":"Factors related to blood pressure in a biracial adolescent female population","volume":"8","author":"Liebman","year":"1986","journal-title":"Hypertension"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.lfs.2007.12.011","article-title":"Tryptophan hydroxylase is modulated by L-type calcium channels in the rat pineal gland","volume":"82","author":"Barbosa","year":"2008","journal-title":"Life Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4688","DOI":"10.1073\/pnas.77.8.4688","article-title":"Activation of brain tryptophan hydroxylase by ATP-MG2+: Dependence on calmodulin","volume":"77","author":"Kuhn","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/jgs.13477","article-title":"Is Self-Reported Sleep Duration Associated with Osteoporosis? Data from a 4-Year Aggregated Analysis from the National Health and Nutrition Examination Survey","volume":"63","author":"Cunningham","year":"2015","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13018-016-0418-6","article-title":"Effects of chronic sleep deprivation on bone mass and bone metabolism in rats","volume":"11","author":"Xu","year":"2016","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/sleep\/30.9.1096","article-title":"Racial differences in self-reports of sleep duration in a population-based study","volume":"30","author":"Hale","year":"2007","journal-title":"Sleep"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"601","DOI":"10.5665\/sleep.3508","article-title":"Short and long sleep duration associated with race\/ethnicity, sociodemographics, and socioeconomic position","volume":"37","author":"Whinnery","year":"2014","journal-title":"Sleep"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"813","DOI":"10.5664\/jcsm.5876","article-title":"Clinical Relevance of Sleep Duration: Results from a Cross-Sectional Analysis Using NHANES","volume":"12","author":"Cepeda","year":"2016","journal-title":"J. Clin. Sleep Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/aje\/kwj231","article-title":"Cigarette smoking and nocturnal sleep architecture","volume":"164","author":"Zhang","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.appet.2012.07.012","article-title":"Short sleep duration is associated with greater alcohol consumption in adults","volume":"59","author":"Chaput","year":"2012","journal-title":"Appetite"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2335\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:26:46Z","timestamp":1760189206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,1]]},"references-count":57,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["nu11102335"],"URL":"https:\/\/doi.org\/10.3390\/nu11102335","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,1]]}}}