{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:27:47Z","timestamp":1792189667944,"version":"4.4.0"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","award":["AGL2008-01057"],"award-info":[{"award-number":["AGL2008-01057"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["AGR832"],"award-info":[{"award-number":["AGR832"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Diet plays a decisive role in heart physiology, with lipids having especial importance in pathology prevention and development. This study aimed to investigate how dietary lipids varying in lipid profile (virgin olive oil, sunflower oil or fish oil) affected the heart of rats during aging. Heart histopathology, mitochondrial morphometry, and oxidative status were assessed. Typical histopathological features associated with aging, such as valvular lesions, endomyocardical hyperplasia, or papillary muscle calcification, were found at a low extent in all the experimental groups. The most relevant finding was that inflammation registered by fish oil group was lower compared to the other treatments. At the ultrastructural level, heart mitochondrial area, perimeter, and aspect ratio were higher in fish oil-fed rats than in those fed on sunflower oil. Concerning oxidative stress markers, there were differences only in coenzyme Q levels and catalase activity, lower in sunflower oil-fed animals compared with those fed on fish oil. In summary, dietary intake for a long period on dietary fats with different fatty acids profile led to differences in some aspects associated with the aging process at the heart. Fish oil seems to be the fat most protective of heart during aging.<\/jats:p>","DOI":"10.3390\/nu11102390","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:05:12Z","timestamp":1570442712000},"page":"2390","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Heart Histopathology and Mitochondrial Ultrastructure in Aged Rats Fed for 24 Months on Different Unsaturated Fats (Virgin Olive Oil, Sunflower Oil or Fish Oil) and Affected by Different Longevity"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-8379","authenticated-orcid":false,"given":"Mar\u00eda D.","family":"Navarro-Hortal","sequence":"first","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Center, University of Granada, Avda del Conocimiento sn., 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-707X","authenticated-orcid":false,"given":"C\u00e9sar L.","family":"Ram\u00edrez-Tortosa","sequence":"additional","affiliation":[{"name":"UGC de Anatom\u00eda Patol\u00f3gica, Hospital San Cecilio de Granada, Avda, Conocimiento s\/n, 18100 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-5086","authenticated-orcid":false,"given":"Alfonso","family":"Varela-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Center, University of Granada, Avda del Conocimiento sn., 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Romero-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Center, University of Granada, Avda del Conocimiento sn., 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8976-6296","authenticated-orcid":false,"given":"Julio J.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Center, University of Granada, Avda del Conocimiento sn., 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-0881","authenticated-orcid":false,"given":"MCarmen","family":"Ram\u00edrez-Tortosa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Center, University of Granada, Avda del Conocimiento sn., 18100 Armilla, Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Y.","family":"Forbes-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, 36310 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Granados-Principal","sequence":"additional","affiliation":[{"name":"UGC de Oncolog\u00eda M\u00e9dica, Hospital Universitario de Ja\u00e9n, Avenida del Ej\u00e9rcito Espa\u00f1ol 10, 23007 Ja\u00e9n, Spain"},{"name":"Genyo, Centre for Genomics and Oncological Research, Pfizer\/University of Granada\/Andalusian Regional Government, PTS Granada-Avenida de la Ilustraci\u00f3n 114, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-1782","authenticated-orcid":false,"given":"Maurizio","family":"Battino","sequence":"additional","affiliation":[{"name":"Nutrition and Food Science Group, Department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo, 36310 Vigo, Spain"},{"name":"Dipartimento di Scienze Cliniche Specialistiche ed Odontostomatologiche\u2014Sez. 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