{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T09:58:23Z","timestamp":1791367103895,"version":"4.3.1"},"reference-count":58,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["P11-AGR-7648"],"award-info":[{"award-number":["P11-AGR-7648"]}],"id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency anemia (IDA) is one of the most prevalent nutritional deficiencies worldwide. Iron plays critical roles in nervous system development and cognition. Despite the known detrimental consequences of IDA on cognition, available studies do not provide molecular mechanisms elucidating the role of iron in brain functions during iron deficiency and recovery with dairy components. In this study, 100 male Wistar rats were placed on a pre-experimental period of 40 days and randomly divided in two groups: a control group receiving a normal-Fe diet, (45 mg\/kg), and an Fe-deficient group receiving a low-Fe diet (5 mg\/kg). At day 40, 10 rats per group were sacrificed to anemia control, and 80 rats were divided into eight experimental groups fed with fermented goat or cow milk-based diets, with normal Fe content or Fe overload (450 mg\/kg) for 30 days. IDA decreased most of the parameters related to brain molecular functions, namely dopamine, irisin, MAO-A, oxytocin, \u03b2-endorphin, and \u03b1-MSH, while it increased synaptophysin. These alterations result in an impairment of brain molecular functions. In general, during anemia recovery, fermented goat milk diet consumption increased dopamine, oxytocin, serotonin, synaptophysin, and \u03b1-MSH, and decreased MAO-A and MAO-B, suggesting a potential neuroprotective effect in brain functions, which could enhance brain molecular functions.<\/jats:p>","DOI":"10.3390\/nu11102394","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T10:05:12Z","timestamp":1570442712000},"page":"2394","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fermented Goat Milk Consumption Enhances Brain Molecular Functions during Iron Deficiency Anemia Recovery"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9690-7851","authenticated-orcid":false,"given":"Jorge","family":"Moreno-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, E-18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, E-18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"L\u00f3pez-Aliaga","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, E-18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, E-18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Garc\u00eda-Burgos","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, E-18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, E-18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"J.M. Alf\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, E-18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, E-18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-1757","authenticated-orcid":false,"given":"Javier","family":"D\u00edaz-Castro","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Pharmacy, Campus Universitario de Cartuja, E-18071 Granada, Spain"},{"name":"Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, University of Granada, E-18071 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1001\/jamapediatrics.2015.4276","article-title":"Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study","volume":"170","author":"Kyu","year":"2016","journal-title":"JAMA Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev.nutr.23.020102.075739","article-title":"Iron status and neural functioning","volume":"23","author":"Beard","year":"2003","journal-title":"Ann. Rev. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Cusick, S.E., Georgieff, M.K., and Rao, R. (2018). Approaches for Reducing the Risk of Early-Life Iron Deficiency-Induced Brain Dysfunction in Children. Nutrients, 10.","DOI":"10.3390\/nu10020227"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3945\/jn.117.255356","article-title":"Consumption of Iron-Biofortified Beans Positively Affects Cognitive Performance in 18- to 27-Year-Old Rwandan Female College Students in an 18-Week Randomized Controlled Efficacy Trial","volume":"147","author":"Wenger","year":"2017","journal-title":"J. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/1028415X.2017.1360559","article-title":"Effect of iron deficiency on simultaneous measures of behavior, brain activity, and energy expenditure in the performance of a cognitive task","volume":"22","author":"Wenger","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/MCO.0b013e3283653ef8","article-title":"Iron and brain functions","volume":"16","year":"2013","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/S0272-6386(99)70150-2","article-title":"Normalizing hematocrit in dialysis patients improves brain function","volume":"33","author":"Pickett","year":"1999","journal-title":"Am. J. Kidney Dis. Off. J. Natl. Kidney Found."},{"key":"ref_8","first-page":"21","article-title":"Epoetin and cognitive function","volume":"20","author":"Nissenson","year":"1992","journal-title":"Am. J. Kidney Dis. Off. J. Natl. Kidney Found."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1681\/ASN.V112335","article-title":"Increasing the Hematocrit Has a Beneficial Effect on Quality of Life and Is Safe in Selected Hemodialysis Patients","volume":"11","author":"Moreno","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2891-9-4","article-title":"The effects of oral iron supplementation on cognition in older children and adults: A systematic review and meta-analysis","volume":"9","author":"Falkingham","year":"2010","journal-title":"Nutr. J."},{"key":"ref_11","unstructured":"Bahrami, A., and Khorasanchi, Z. (2019). Anemia is associated with cognitive impairment in adolescent girls: A cross-sectional survey. Appl. Neuropsychol. Child, 1\u20137."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S0007114511000158","article-title":"Dairy constituents and neurocognitive health in ageing","volume":"106","author":"Camfield","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_13","first-page":"161","article-title":"Dairy intake and cognitive health in middle-aged South Australians","volume":"19","author":"Crichton","year":"2010","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1021\/acs.jafc.6b00108","article-title":"Fermented Goat\u2019s Milk Consumption Improves Duodenal Expression of Iron Homeostasis Genes during Anemia Recovery","volume":"64","author":"Alferez","year":"2016","journal-title":"J. Agric. food Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1017\/S0022029915000722","article-title":"Production and chemical composition of two dehydrated fermented dairy products based on cow or goat milk","volume":"83","author":"Alferez","year":"2016","journal-title":"J. Dairy Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/jn\/123.11.1939","article-title":"AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet","volume":"123","author":"Reeves","year":"1993","journal-title":"J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1079\/BJN19930152","article-title":"Effect of iron deficiency on the digestive utilization of iron, phosphorus, calcium and magnesium in rats","volume":"70","author":"Pallares","year":"1993","journal-title":"Br. J. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2141.1994.tb03267.x","article-title":"Intestinal iron absorption studies in mouse models of iron-overload","volume":"86","author":"Raja","year":"1994","journal-title":"Br. J. Haematol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1301\/nr.2006.may.S34-S43","article-title":"Long-lasting neural and behavioral effects of iron deficiency in infancy","volume":"64","author":"Lozoff","year":"2006","journal-title":"Nutr. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00008506-200604000-00007","article-title":"The brain erythropoietin system and its potential for therapeutic exploitation in brain disease","volume":"18","author":"Hasselblatt","year":"2006","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10534-012-9550-x","article-title":"Iron deficiency on neuronal function","volume":"25","author":"Munoz","year":"2012","journal-title":"Biometals Int. J. Role Met. Ions Biol. Biochem. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0301-0082(02)00011-4","article-title":"Dopamine and the regulation of cognition and attention","volume":"67","author":"Nieoullon","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.3945\/jn.108.095224","article-title":"Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissue","volume":"138","author":"Unger","year":"2008","journal-title":"J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Moreno-Fernandez, J., and Diaz-Castro, J. (2019). Iron Deficiency and Neuroendocrine Regulators of Basal Metabolism, Body Composition and Energy Expenditure in Rats. Nutrients, 11.","DOI":"10.3390\/nu11030631"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0959-4388(95)80028-X","article-title":"Stress and cognitive function","volume":"5","author":"McEwen","year":"1995","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/ajcn\/50.3.607","article-title":"Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior","volume":"50","author":"Youdim","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1471-4159.1989.tb02515.x","article-title":"Effect of latent iron deficiency on 5-hydroxytryptamine metabolism in rat brain","volume":"52","author":"Shukla","year":"1989","journal-title":"J. Neurochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1172\/JCI108489","article-title":"Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction","volume":"58","author":"Finch","year":"1976","journal-title":"J. Clin. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1080\/1028415X.1999.11747287","article-title":"Sex and Genetics are Important Cofactors in Assessing the Impact of Iron Deficiency on the Developing Mouse Brain","volume":"2","author":"Morse","year":"1999","journal-title":"Nutr. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1111\/j.1471-4159.1983.tb08155.x","article-title":"Effect of maternal iron deficiency in rat on serotonin uptake in vitro by brain synaptic vesicles in the offspring","volume":"40","author":"Kaladhar","year":"1983","journal-title":"J. Neurochem."},{"key":"ref_32","first-page":"19","article-title":"Minimal brain damage induced by early iron deficiency: Modified dopaminergic neurotransmission","volume":"23","author":"Youdim","year":"1987","journal-title":"Isr. J. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.3945\/jn.111.145946","article-title":"Severe postnatal iron deficiency alters emotional behavior and dopamine levels in the prefrontal cortex of young male rats","volume":"141","author":"Li","year":"2011","journal-title":"J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3233\/BPL-150019","article-title":"FNDC5\/irisin\u2014Their role in the nervous system and as a mediator for beneficial effects of exercise on the brain","volume":"1","author":"Wrann","year":"2015","journal-title":"Brain Plast."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3945\/jn.114.201798","article-title":"Fetal iron deficiency and genotype influence emotionality in infant rhesus monkeys","volume":"145","author":"Golub","year":"2015","journal-title":"J. Nutr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0169-328X(96)00137-4","article-title":"Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus-further evidence for carbon monoxide as a neuromodulator","volume":"42","author":"Forsling","year":"1996","journal-title":"Brain Res. Mol. Brain Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"874610","DOI":"10.1155\/2014\/874610","article-title":"Alpha-melanocyte stimulating hormone: An emerging anti-inflammatory antimicrobial peptide","volume":"2014","author":"Singh","year":"2014","journal-title":"BioMed Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-8118-12-3","article-title":"The effects of beta-endorphin: State change modification","volume":"12","author":"Veening","year":"2015","journal-title":"Fluids Barriers CNS"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Gordon, S.L., Harper, C.B., Smillie, K.J., and Cousin, M.A. (2016). A Fine Balance of Synaptophysin Levels Underlies Efficient Retrieval of Synaptobrevin II to Synaptic Vesicles. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0149457"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0306-4522(02)00319-6","article-title":"Effect of prenatal auditory enrichment on developmental expression of synaptophysin and syntaxin 1 in chick brainstem auditory nuclei","volume":"114","author":"Alladi","year":"2002","journal-title":"Neuroscience"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neulet.2007.05.026","article-title":"Inhibition of nitric oxide synthase increases synaptophysin mRNA expression in the hippocampal formation of rats","volume":"421","author":"Joca","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ano, Y., Ozawa, M., Kutsukake, T., Sugiyama, S., Uchida, K., Yoshida, A., and Nakayama, H. (2015). Preventive effects of a fermented dairy product against Alzheimer\u2019s disease and identification of a novel oleamide with enhanced microglial phagocytosis and anti-inflammatory activity. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0118512"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1039\/C8FO00552D","article-title":"Fermented goat milk consumption improves iron status and evokes inflammatory signalling during anemia recovery","volume":"9","author":"Alferez","year":"2018","journal-title":"Food Funct."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1523\/JNEUROSCI.0172-13.2013","article-title":"Targeting Alzheimer\u2019s pathology through PPARgamma signaling: Modulation of microglial function","volume":"33","author":"Lourenco","year":"2013","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0002-9440(10)65542-3","article-title":"Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer\u2019s disease brains","volume":"153","author":"Xia","year":"1998","journal-title":"Am. J. Pathol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3233\/JAD-2005-8406","article-title":"Potential inflammatory biomarkers in Alzheimer\u2019s disease","volume":"8","author":"Mrak","year":"2005","journal-title":"J. Alzheimer\u2019s Dis. JAD"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer\u2019s disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Chi, H., Chang, H.-Y., and Sang, T.-K. (2018). Neuronal cell death mechanisms in major neurodegenerative diseases. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103082"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1039\/C5FO01299F","article-title":"Fermented goat milk consumption improves melatonin levels and influences positively the antioxidant status during nutritional ferropenic anemia recovery","volume":"7","author":"Alferez","year":"2016","journal-title":"Food Funct."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/jsfa.7882","article-title":"Fermented goat milk improves antioxidant status and protects from oxidative damage to biomolecules during anemia recovery","volume":"97","author":"Alferez","year":"2017","journal-title":"J. Sci. Food Agric."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1093\/brain\/aww022","article-title":"Iron and dopamine: A toxic couple","volume":"139","author":"Hare","year":"2016","journal-title":"Brain J. Neurol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00702-014-1362-4","article-title":"Modulation of monoamine oxidase (MAO) expression in neuropsychiatric disorders: Genetic and environmental factors involved in type A MAO expression","volume":"123","author":"Naoi","year":"2016","journal-title":"J. Neural Transm."},{"key":"ref_53","first-page":"25","article-title":"BETA\u2014Endorphins\u2014A Novel Natural Holistic Healer","volume":"10","author":"Shrihari","year":"2018","journal-title":"J. Microb. Biochem. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s12640-010-9181-3","article-title":"Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats","volume":"19","author":"Miwa","year":"2011","journal-title":"Neurotox. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neurobiolaging.2018.07.016","article-title":"Novel lactopeptides in fermented dairy products improve memory function and cognitive decline","volume":"72","author":"Ano","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_56","first-page":"53","article-title":"Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson\u2019s disease: Possible implications of glial cells","volume":"71","author":"Nagatsu","year":"2006","journal-title":"J. Neural Transm. Suppl."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"21986","DOI":"10.1038\/srep21986","article-title":"Inhibitory effect of traditional oriental medicine-derived monoamine oxidase B inhibitor on radioresistance of non-small cell lung cancer","volume":"6","author":"Son","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1749-6632.2003.tb03172.x","article-title":"New insights into the functions of alpha-MSH and related peptides in the immune system","volume":"994","author":"Luger","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2394\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:28:05Z","timestamp":1760189285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,7]]},"references-count":58,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["nu11102394"],"URL":"https:\/\/doi.org\/10.3390\/nu11102394","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,7]]}}}