{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:21Z","timestamp":1787029161942,"version":"build-2736575974"},"reference-count":55,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI12\/02777"],"award-info":[{"award-number":["PI12\/02777"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal\u2013fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110\u2013130g\/L, received 40 or 80mg iron daily) and Stratum 2 (Hb &gt; 130g\/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg\/d instead of 40 mg\/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg\/d instead of 40 mg\/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) \u2265 15 \u03bcg\/L, while 40 mg\/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy.<\/jats:p>","DOI":"10.3390\/nu11102418","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T03:07:11Z","timestamp":1570763231000},"page":"2418","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Effectiveness of Different Doses of Iron Supplementation and the Prenatal Determinants of Maternal Iron Status in Pregnant Spanish Women: ECLIPSES Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-4144","authenticated-orcid":false,"given":"Luc\u00eda","family":"Iglesias V\u00e1zquez","sequence":"first","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Arija","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"},{"name":"Tarragona\u2013Reus Research Support Unit, Jordi Gol University Institute for Primary Care Research, 43202 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00faria","family":"Aranda","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0542-0015","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Aparicio","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, 43201 Reus, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-2017","authenticated-orcid":false,"given":"N\u00faria","family":"Serrat","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, University Hospital Joan XXIII, Institut Catal\u00e0 de la Salut, Generalitat de Catalunya, 43005 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Fargas","sequence":"additional","affiliation":[{"name":"Sexual and Reproductive Health Service of Reus\u2013Tarragona, Institut Catal\u00e0 de la Salut, Generalitat de Catalunya, 43202 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Sexual and Reproductive Health Service of Reus\u2013Tarragona, Institut Catal\u00e0 de la Salut, Generalitat de Catalunya, 43202 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Pallej\u00e0","sequence":"additional","affiliation":[{"name":"Tarragona\u2013Reus Research Support Unit, Jordi Gol University Institute for Primary Care Research, 43202 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Coronel","sequence":"additional","affiliation":[{"name":"Meiji Pharma Spain S.A. (formerly Tedec-Meiji Farma S.A.) Alcal\u00e1 de Henares, 28802 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Meiji Pharma Spain S.A. (formerly Tedec-Meiji Farma S.A.) Alcal\u00e1 de Henares, 28802 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Basora","sequence":"additional","affiliation":[{"name":"Tarragona\u2013Reus Research Support Unit, Jordi Gol University Institute for Primary Care Research, 43202 Tarragona, Spain"},{"name":"CIBERobn (Center for Biomedical Research in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,10]]},"reference":[{"key":"ref_1","unstructured":"De Benoist, B., McLean, E., Egli, I., and Cogswell, M. (2008). 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