{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:15:32Z","timestamp":1780395332293,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Chronic and extensive exposure of ultraviolet (UV)-irradiation causes human skin sunburn, inflammation, or photoaging, which is associated with downregulated collagen synthesis. This study investigated the effects of fermented blackberry (Rubus fruticosus B., FBB) by Lactobacillus plantarum JBMI F5 (LP) on UVB-induced photoaging in human foreskin fibroblast (Hs68) as well as in SKH-1 hairless mice. FBB pretreatment inhibited UVB-mediated type-1 procollagen degradation, matrix metalloproteinase (MMP)-1 and MMP-2 protein expression, and suppressed nuclear factor-\u03baB (NF-\u03baB) activation as well as mitogen-activated protein kinase (MAPK) phosphorylation in Hs68. In addition, FBB administration diminished the wrinkle formation in dorsal skin and epidermal thickening in UVB-irradiated hairless mice. Moreover, UVB-induced Type-1 procollagen reduction and antioxidant enzyme inactivation were reversed by FBB administration. These results suggest that FBB may have antiphotoaging effects on UVB-induced wrinkle formation by maintaining the extracellular matrix density in the dermis, which occurs via regulation of reactive oxygen species and related MAPK and NF-\u03baB signaling. Therefore, FBB can be a potential candidate for protecting skin aging against UV irradiation.<\/jats:p>","DOI":"10.3390\/nu11102429","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T10:53:03Z","timestamp":1570791183000},"page":"2429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Fermentation of Blackberry with L. plantarum JBMI F5 Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK\/NF-\u03baB Signaling"],"prefix":"10.3390","volume":"11","author":[{"given":"Ha-Rim","family":"Kim","sequence":"first","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Hye","family":"Jeong","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol","family":"Kim","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Wang","family":"Lee","sequence":"additional","affiliation":[{"name":"Chebigen Co. Ltd., Jeonju 54853, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Sig","family":"Sin","sequence":"additional","affiliation":[{"name":"Chebigen Co. Ltd., Jeonju 54853, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-Yeol","family":"Yu","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Il","family":"Jeong","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9266-4618","authenticated-orcid":false,"given":"Seon-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Deokjin-gu, Jeonju-si, Jeollabuk-do 54810, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.maturitas.2011.04.011","article-title":"Molecular aspects of skin ageing","volume":"69","author":"Naylor","year":"2011","journal-title":"Maturitas"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/jidsymp.2009.8","article-title":"Matrix-degrading metalloproteinases in photoaging","volume":"14","author":"Quan","year":"2009","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1568-1637(02)00024-7","article-title":"UV-light-induced signal cascades and skin aging","volume":"1","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0923-1811(01)00120-7","article-title":"Role of active oxygen species and antioxidants in photoaging","volume":"27","author":"Yamamoto","year":"2001","journal-title":"J. Dermatol. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1038\/sj.jid.5700340","article-title":"Oxidative Stress in the Pathogenesis of Skin Disease","volume":"126","author":"Bickers","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_6","first-page":"15","article-title":"The development of gut immune responses and gut microbiota: Effects of probiotics in prevention and treatment of allergic disease","volume":"3","author":"Rautava","year":"2002","journal-title":"Curr. Issues Intestig. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/j.1365-2672.2006.02963.x","article-title":"Probiotics and their fermented food products are beneficial for health","volume":"100","author":"Parvez","year":"2006","journal-title":"J. Appl. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1365-2133.2010.09888.x","article-title":"Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet-induced skin damage","volume":"163","author":"Jeannes","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.4014\/jmb.1406.06038","article-title":"Oral administration of Lactobacillus plantarum HY7714 protects hairless mouse against ultraviolet B-induced photoaging","volume":"24","author":"Kim","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1542\/peds.2013-0246","article-title":"Probiotic Administration in Early Life, Atopy, and Asthma: A Meta-analysis of Clinical Trials","volume":"132","author":"ElAzab","year":"2013","journal-title":"Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/ptr.3510","article-title":"Anthocyanin-rich Fractions of Blackberry Extracts Reduce UV-induced Free Radicals and Oxidative Damage in Keratinocytes","volume":"26","author":"Murapa","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.taap.2015.02.003","article-title":"Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-\u03baB signaling pathways in SKH-1 mice skin","volume":"284","author":"Divya","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/php.12104","article-title":"Protective effect of tropical highland blackberry juice (Rubus adenotrichos Schltdl.) against UVB-mediated damage in human epidermal keratinocytes and in a reconstituted skin equivalent model","volume":"89","author":"Syed","year":"2013","journal-title":"Photochem. Photobiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jfca.2011.01.008","article-title":"Comparison of ABTS\/DPPH assays to measure antioxidant capacity in popular antioxidant-rich US foods","volume":"24","author":"Floegel","year":"2011","journal-title":"J. Food Compos. Anal."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"F982","DOI":"10.1152\/ajprenal.00483.2007","article-title":"Molecular mechanism of ADP-ribosyl cyclase activation in angiotensin II signaling in murine mesangial cells","volume":"294","author":"Kim","year":"2008","journal-title":"Am. J. Physiol. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1021\/jf1049535","article-title":"Production of Fibrinolytic Enzyme from Bacillus amyloliquefaciens by Fermentation of Chickpeas, with the Evaluation of the Anticoagulant and Antioxidant Properties of Chickpeas","volume":"59","author":"Wei","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0891-5849(98)00212-3","article-title":"Antioxidants modulate acute solar ultraviolet radiation-induced NF-kappa-B activation in a human keratinocyte cell line","volume":"26","author":"Saliou","year":"1999","journal-title":"Free Radic. Boil. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3858\/emm.2009.41.8.060","article-title":"Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-\u03baB pathway in human dermal fibroblasts","volume":"41","author":"Lee","year":"2009","journal-title":"Exp. Mol. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1124\/jpet.105.088674","article-title":"Prevention of the Ultraviolet B-Mediated Skin Photoaging by a Nuclear Factor \u03baB Inhibitor, Parthenolide","volume":"315","author":"Tanaka","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.taap.2003.08.019","article-title":"Toxic effects of ultraviolet radiation on the skin","volume":"195","author":"Matsumura","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/sj.onc.1200973","article-title":"Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades","volume":"14","author":"Gum","year":"1997","journal-title":"Oncogene"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.foodres.2018.11.059","article-title":"Anti-inflammatory and wound healing properties of polyphenolic extracts from strawberry and blackberry fruits","volume":"121","author":"Esposito","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1080\/10408398.2017.1383355","article-title":"Health benefits of fermented foods","volume":"59","author":"Sezgin","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Shin, D., Lee, Y., Huang, Y.-H., Lim, H.-W., Jang, K., Kim, D.-D., and Lim, C.-J. (2018). Probiotic fermentation augments the skin anti-photoaging properties of Agastache rugosa through up-regulating antioxidant components in UV-B-irradiated HaCaT keratinocytes. BMC Complement. Altern. Med., 18.","DOI":"10.1186\/s12906-018-2194-9"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12934-015-0250-4","article-title":"Lactic acid fermentation as a tool to enhance the antioxidant properties of Myrtus communis berries","volume":"14","author":"Curiel","year":"2015","journal-title":"Microb. Cell Factories"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1001\/archderm.138.11.1462","article-title":"Mechanisms of photoaging and chronological skin aging","volume":"138","author":"Fisher","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/jid.2012.164","article-title":"NF-\u03baB Accumulation Associated with COL1A1 Trans activators Defects during Chronological Aging Represses Type I Collagen Expression through a \u2212112\/\u221261-bp Region of the COL1A1 Promoter in Human Skin Fibroblasts","volume":"132","author":"Bigot","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2174\/138920010791526051","article-title":"Protecting skin photoaging by NF-kappaB inhibitor","volume":"11","author":"Tanaka","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1749-6632.2002.tb04602.x","article-title":"Ultraviolet-B Irradiation and Matrix Metalloproteinases","volume":"973","author":"Brenneisen","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/ics.12520","article-title":"Olive oil inhibits ageing signs induced by chronic stress in ex vivo human skin via inhibition of extracellular-signal-related kinase 1\/2 and c- JUN pathways","volume":"41","year":"2019","journal-title":"Int. J. Cosmet. Sci."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:25:28Z","timestamp":1760189128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["nu11102429"],"URL":"https:\/\/doi.org\/10.3390\/nu11102429","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]}}}