{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:05:34Z","timestamp":1789646734498,"version":"4.0.0"},"reference-count":76,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","award":["7142"],"award-info":[{"award-number":["7142"]}],"id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Acci\u00f3n 5: Ayudas para estancias breves del Personal Investigador en Formaci\u00f3n de la Universidad de Ja\u00e9n","award":["554"],"award-info":[{"award-number":["554"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Stroke is one of the leading causes of adult disability worldwide. After ischemic stroke, damaged tissue surrounding the irreversibly damaged core of the infarct, the penumbra, is still salvageable and is therefore a target for acute therapeutic strategies. The Mediterranean diet (MD) has been shown to lower stroke risk. MD is characterized by increased intake of extra-virgin olive oil, of which hydroxytyrosol (HT) is the foremost phenolic component. This study investigates the effect of an HT-enriched diet directly after stroke on regaining motor and cognitive functioning, MRI parameters, neuroinflammation, and neurogenesis. Stroke mice on an HT diet showed increased strength in the forepaws, as well as improved short-term recognition memory probably due to improvement in functional connectivity (FC). Moreover, mice on an HT diet showed increased cerebral blood flow (CBF) and also heightened expression of brain derived neurotrophic factor (Bdnf), indicating a novel neurogenic potential of HT. This result was additionally accompanied by an enhanced transcription of the postsynaptic marker postsynaptic density protein 95 (Psd-95) and by a decreased ionized calcium-binding adapter molecule 1 (IBA-1) level indicative of lower neuroinflammation. These results suggest that an HT-enriched diet could serve as a beneficial therapeutic approach to attenuate ischemic stroke-associated damage.<\/jats:p>","DOI":"10.3390\/nu11102430","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T03:54:13Z","timestamp":1571025253000},"page":"2430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Hydroxytyrosol, the Major Phenolic Compound of Olive Oil, as an Acute Therapeutic Strategy after Ischemic Stroke"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6399-751X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Calahorra","sequence":"first","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, Campus Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Shenk","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera H.","family":"Wielenga","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne","family":"Verweij","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7838-3097","authenticated-orcid":false,"given":"Bram","family":"Geenen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter J.","family":"Dederen","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. \u00c1ngeles","family":"Peinado","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, Campus Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-7008","authenticated-orcid":false,"given":"Eva","family":"Siles","sequence":"additional","affiliation":[{"name":"Department of Experimental Biology, University of Ja\u00e9n, Campus Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1412-398X","authenticated-orcid":false,"given":"Maximilian","family":"Wiesmann","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Kiliaan","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Donders Institute for Brain, Cognition & Behaviour, Radboud Alzheimer Center, Department of Anatomy, Preclinical Imaging Centre PRIME, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"ref_1","unstructured":"Nichols, M., Townsend, N., Luengo-Fernandez, R., Leal, J., Gray, A., Scarborough, P., and Rayner, M. (2012). European Cardiovascular Disease Statistics, European Heart Network AISBL. 2012 Edition."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1471-4159.2012.07721.x","article-title":"Sex differences in brain proteomes of neuron-specific STAT3-null mice after cerebral ischemia\/reperfusion","volume":"121","author":"Casalena","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/ene.12743","article-title":"Post-stroke cognitive impairment is common even after successful clinical recovery","volume":"22","author":"Jokinen","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1111\/j.1582-4934.2010.01135.x","article-title":"Neuroprotection in acute ischemic stroke\u2013current status","volume":"14","author":"Auriel","year":"2010","journal-title":"J. Cell. Mol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.neurobiolaging.2013.09.038","article-title":"Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer\u2019s disease","volume":"35","author":"Zerbi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11883-013-0331-y","article-title":"New evidence for therapies in stroke rehabilitation","volume":"15","author":"Dobkin","year":"2013","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.neuint.2017.01.013","article-title":"Neuroprotective diets for stroke","volume":"107","author":"Ayuso","year":"2017","journal-title":"Neurochem. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/jnc.14213","article-title":"Effect of a multinutrient intervention after ischemic stroke in female C57Bl\/6 mice","volume":"144","author":"Wiesmann","year":"2018","journal-title":"J. Neurochem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.7150\/thno.17559","article-title":"A specific dietary intervention to restore brain structure and function after ischemic stroke","volume":"7","author":"Wiesmann","year":"2017","journal-title":"Theranostics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1017\/S0007114514000713","article-title":"Olive oil consumption and risk of CHD and\/or stroke: A meta-analysis of case\u2013control, cohort and intervention studies","volume":"112","author":"Dominguez","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Estruch, R., Ros, E., Salas-Salvad\u00f3, J., Covas, M.-I., Corella, D., Ar\u00f3s, F., G\u00f3mez-Gracia, E., Ruiz-Guti\u00e9rrez, V., Fiol, M., and Lapetra, J. (2018). Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts. N. Engl. J. Med.","DOI":"10.1056\/NEJMoa1800389"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1100\/tsw.2010.128","article-title":"Dietary virgin olive oil reduces blood brain barrier permeability, brain edema, and brain injury in rats subjected to ischemia-reperfusion","volume":"10","author":"Mohagheghi","year":"2010","journal-title":"Sci. World J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2174\/15672026113109990007","article-title":"Neuroprotection of dietary virgin olive oil on brain lipidomics during stroke","volume":"10","author":"Rabiei","year":"2013","journal-title":"Curr. Neurovasc. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.nut.2015.05.023","article-title":"Dietary fats significantly influence the survival of penumbral neurons in a rat model of chronic ischemic by modifying lipid mediators, inflammatory biomarkers, NOS production, and redox-dependent apoptotic signals","volume":"31","author":"Lausada","year":"2015","journal-title":"Nutrition"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1753-4887.2010.00278.x","article-title":"Hydroxytyrosol: From laboratory investigations to future clinical trials","volume":"68","author":"Quiles","year":"2010","journal-title":"Nutr. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1021\/jf0501948","article-title":"Characterization and quantification of phenolic compounds in olive oils by solid-phase extraction, HPLC-DAD, and HPLC-MS\/MS","volume":"53","author":"Jauregui","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Robles-Almazan, M., Pulido-Moran, M., Moreno-Fernandez, J., Ramirez-Tortosa, C., Rodriguez-Garcia, C., Quiles, J.L., and Ramirez-Tortosa, M. (2017). Hydroxytyrosol: Bioavailability, toxicity, and clinical applications. Food Res. Int.","DOI":"10.1016\/j.foodres.2017.11.053"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2008.09.022","article-title":"Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia\u2013reoxygenation","volume":"446","author":"Navas","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/j.jnutbio.2013.08.007","article-title":"Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation","volume":"24","author":"Cabrerizo","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jnutbio.2014.12.013","article-title":"Role of the catechol group in the antioxidant and neuroprotective effects of virgin olive oil components in rat brain","volume":"26","author":"Guerrero","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5957","DOI":"10.1021\/acs.jafc.5b00627","article-title":"Differences in the neuroprotective effect of orally administered virgin olive oil (Olea europaea) polyphenols tyrosol and hydroxytyrosol in rats","volume":"63","author":"Guerrero","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1021\/acs.jafc.6b02945","article-title":"Neuroprotective effect of hydroxytyrosol in experimental diabetes mellitus","volume":"65","author":"Reyes","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"236","DOI":"10.30802\/AALAS-JAALAS-17-000122","article-title":"Effect of Environmental Enrichment on Aggression in BALB\/cJ and BALB\/cByJ Mice Monitored by Using an Automated System","volume":"57","author":"Giles","year":"2018","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Pernold, K., Iannello, F., Low, B.E., Rigamonti, M., Rosati, G., Scavizzi, F., Wang, J., Raspa, M., Wiles, M.V., and Ulfhake, B. (2019). Towards large scale automated cage monitoring\u2014Diurnal rhythm and impact of interventions on in-cage activity of C57BL\/6J mice recorded 24\/7 with a non-disrupting capacitive-based technique. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211063"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.fct.2017.07.009","article-title":"Proteomic evaluation of mouse adipose tissue and liver following hydroxytyrosol supplementation","volume":"107","author":"Crespo","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.numecd.2014.05.003","article-title":"Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: A nutrigenomic study","volume":"24","author":"Giordano","year":"2014","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jnutbio.2016.05.009","article-title":"Hydroxytyrosol supplementation modulates the expression of miRNAs in rodents and in humans","volume":"34","author":"Crespo","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbr.2004.07.002","article-title":"Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit","volume":"157","author":"Streijger","year":"2005","journal-title":"Behav. Brain Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jnutbio.2014.08.002","article-title":"Impact of dietary n-3 polyunsaturated fatty acids on cognition, motor skills and hippocampal neurogenesis in developing C57BL\/6J mice","volume":"26","author":"Janssen","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: Neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"key":"ref_31","unstructured":"Paxinos, G., and Franklin, K.B. (2004). The Mouse Brain in Stereotaxic Coordinates, Gulf Professional Publishing."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/nbm.1496","article-title":"In vivo diffusion tensor magnetic resonance imaging and fiber tracking of the mouse brain","volume":"23","author":"Harsan","year":"2010","journal-title":"NMR Biomed."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Jansen, D., Zerbi, V., Arnoldussen, I.A.C., Wiesmann, M., Rijpma, A., Fang, X.T., Dederen, P.J., Mutsaers, M.P.C., Broersen, L.M., and L\u00fctjohann, D. (2013). Effects of Specific Multi-Nutrient Enriched Diets on Cerebral Metabolism, Cognition and Neuropathology in A\u03b2PPswe-PS1dE9 Mice. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075393"},{"key":"ref_34","first-page":"1841","article-title":"Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout mice","volume":"219","author":"Jansen","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuroimage.2010.06.014","article-title":"Patching cardiac and head motion artefacts in diffusion-weighted images","volume":"53","author":"Zwiers","year":"2010","journal-title":"Neuroimage"},{"key":"ref_36","unstructured":"Paxinos, G., and Franklin, K.B. (2004). The Mouse Brain in Stereotaxic Coordinates, Academic."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jonckers, E., Van Audekerke, J., De Visscher, G., Van der Linden, A., and Verhoye, M. (2011). Functional connectivity fMRI of the rodent brain: Comparison of functional connectivity networks in rat and mouse. PloS ONE, 6.","DOI":"10.1371\/journal.pone.0018876"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Janssen, C.I., Jansen, D., Mutsaers, M.P., Dederen, P.J., Geenen, B., Mulder, M.T., and Kiliaan, A.J. (2016). The effect of a high-fat diet on brain plasticity, inflammation and cognition in female ApoE4-knockin and ApoE-knockout mice. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155307"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.niox.2005.05.003","article-title":"Evidence of a decrease in nitric oxide-storage molecules following acute hypoxia and\/or hypobaria, by means of chemiluminescence analysis","volume":"13","author":"Molina","year":"2005","journal-title":"Nitric Oxide"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijcard.2006.08.032","article-title":"Age and sex-related serum changes in nitric oxide: Correlations with serological markers","volume":"121","author":"Peinado","year":"2007","journal-title":"Int. J. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1021\/ac00199a007","article-title":"Nanogram nitrite and nitrate determination in environmental and biological materials by vanadium (III) reduction with chemiluminescence detection","volume":"61","author":"Braman","year":"1989","journal-title":"Anal. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"Volume 52","author":"Buege","year":"1978","journal-title":"Methods in Enzymology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.phymed.2010.06.007","article-title":"The neuroprotective effect of olive leaf extract is related to improved blood\u2013brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia","volume":"18","author":"Mohagheghi","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejphar.2016.02.027","article-title":"Oleuropein, a natural extract from plants, offers neuroprotection in focal cerebral ischemia\/reperfusion injury in mice","volume":"775","author":"Yu","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Turck, D., Bresson, J.L., Burlingame, B., Dean, T., Fairweather-Tait, S., Heinonen, M., Hirsch-Ernst, K.I., and Mangelsdorf, I. (2017). Safety of hydroxytyrosol as a novel food pursuant to Regulation (EC) No 258\/97. EFSA J., 15, e04728.","DOI":"10.2903\/j.efsa.2017.4728"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Bellumori, M., Cecchi, L., Innocenti, M., Clodoveo, M.L., Corbo, F., and Mulinacci, N. (2019). The EFSA health claim on olive oil polyphenols: Acid hydrolysis validation and total hydroxytyrosol and tyrosol determination in Italian virgin olive oils. Molecules, 24.","DOI":"10.3390\/molecules24112179"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.fct.2013.01.030","article-title":"Toxicological evaluation of pure hydroxytyrosol","volume":"55","author":"Canut","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/jcbfm.2012.185","article-title":"Assessing post-stroke behavior in mouse models of focal ischemia","volume":"33","author":"Balkaya","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/STROKEAHA.111.000792","article-title":"Long-term cognitive impairment after first-ever ischemic stroke in young adults","volume":"44","author":"Schaapsmeerders","year":"2013","journal-title":"Stroke"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5607\/en.2014.23.1.104","article-title":"A method for generating a mouse model of stroke: Evaluation of parameters for blood flow, behavior, and survival [corrected]","volume":"23","author":"Park","year":"2014","journal-title":"Exp. Neurobiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/RMR.0000000000000119","article-title":"Resting State BOLD MRI for Perfusion and Ischemia","volume":"26","author":"Kroll","year":"2017","journal-title":"Topics Magn. Reson. Imaging TMRI"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ana.21905","article-title":"Resting interhemispheric functional magnetic resonance imaging connectivity predicts performance after stroke","volume":"67","author":"Carter","year":"2010","journal-title":"Ann. Neurol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1093\/cercor\/bhq140","article-title":"The role of the contralesional motor cortex for motor recovery in the early days after stroke assessed with longitudinal FMRI","volume":"21","author":"Rehme","year":"2010","journal-title":"Cereb. Cortex"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12576-017-0525-0","article-title":"Relationship between cognitive function and regulation of cerebral blood flow","volume":"67","author":"Ogoh","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Wiesmann, M., Zerbi, V., Jansen, D., Haast, R., L\u00fctjohann, D., Broersen, L.M., Heerschap, A., and Kiliaan, A.J. (2016). A dietary treatment improves cerebral blood flow and brain connectivity in aging apoE4 mice. Neural Plast., 2016.","DOI":"10.1155\/2016\/6846721"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.3945\/ajcn.2009.28641","article-title":"Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation","volume":"91","author":"Kennedy","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1021\/jf053011q","article-title":"Neuroprotective effects of resveratrol on cerebral ischemia-induced neuron loss mediated by free radical scavenging and cerebral blood flow elevation","volume":"54","author":"Lu","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.freeradbiomed.2005.02.010","article-title":"The role of free radicals in cerebral hypoxia and ischemia","volume":"39","author":"Rodrigo","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainres.2005.06.060","article-title":"Constitutive nitric oxide synthases are responsible for the nitric oxide production in the ischemic aged cerebral cortex","volume":"1054","author":"Canuelo","year":"2005","journal-title":"Brain Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.3892\/mmr.2016.5001","article-title":"Temporal profiles of blood pressure, circulating nitric oxide, and adrenomedullin as predictors of clinical outcome in acute ischemic stroke patients","volume":"13","author":"Siles","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1053\/jscd.2003.9","article-title":"Plasma nitric oxide (nitrate\/nitrite) levels in acute stroke and their relationship with severity and outcome","volume":"12","author":"Rashid","year":"2003","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_62","first-page":"590","article-title":"Evaluation of serum oxidant\/antioxidant balance in patients with acute stroke","volume":"63","author":"Abdullah","year":"2013","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_63","first-page":"698","article-title":"Oxidative stress and pathophysiology of ischemic stroke: Novel therapeutic opportunities","volume":"12","author":"Rodrigo","year":"2013","journal-title":"CNS Neurol. Disord.-Drug Targets (Former. Curr. Drug Targets-CNS Neurol. Disord.)"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Echeverr\u00eda, F., Ortiz, M., Valenzuela, R., and Videla, L. (2017). Hydroxytyrosol and cytoprotection: A projection for clinical interventions. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18050930"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1471-4159.2009.06307.x","article-title":"Poly (ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia\/reoxygenation is mediated by nitric oxide and factor inhibiting HIF","volume":"111","author":"Siles","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1055\/s-0031-1280022","article-title":"Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages","volume":"77","author":"Richard","year":"2011","journal-title":"Planta Medica"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jnutbio.2015.12.004","article-title":"Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD","volume":"30","author":"Pirozzi","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jff.2016.12.033","article-title":"Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells","volume":"29","author":"Lopez","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Hornedo-Ortega, R., Cerezo, A.B., de Pablos, R.M., Krisa, S., Richard, T., Garc\u00eda-Parrilla, M.C., and Troncoso, A.M. (2018). Phenolic compounds characteristic of the Mediterranean diet in mitigating microglia-mediated neuroinflammation. Front. Cell. Neurosci., 12.","DOI":"10.3389\/fncel.2018.00373"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12975-016-0460-z","article-title":"Neurogenesis in stroke recovery","volume":"8","author":"Koh","year":"2017","journal-title":"Transl. Stroke Res."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/mp.2017.144","article-title":"BDNF at the synapse: Why location matters","volume":"22","author":"Song","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1111\/j.1460-9568.2006.05059.x","article-title":"Brain-derived neurotrophic factor (BDNF) is required for the enhancement of hippocampal neurogenesis following environmental enrichment","volume":"24","author":"Rossi","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1080\/14786419.2014.918977","article-title":"Effects of olive leaf polyphenols on male mouse brain NGF, BDNF and their receptors TrkA, TrkB and p75","volume":"28","author":"Carito","year":"2014","journal-title":"Nat. Product Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.nut.2012.11.007","article-title":"Effects of olive polyphenols administration on nerve growth factor and brain-derived neurotrophic factor in the mouse brain","volume":"29","author":"Tarani","year":"2013","journal-title":"Nutrition"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jnutbio.2014.10.006","article-title":"Maternal hydroxytyrosol administration improves neurogenesis and cognitive function in prenatally stressed offspring","volume":"26","author":"Zheng","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3389\/fnins.2017.00488","article-title":"Effects of environmental enrichment on doublecortin and BDNF expression along the dorso-ventral axis of the dentate gyrus","volume":"11","author":"Gualtieri","year":"2017","journal-title":"Front. Neurosci."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2430\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:25:28Z","timestamp":1760189128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,11]]},"references-count":76,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["nu11102430"],"URL":"https:\/\/doi.org\/10.3390\/nu11102430","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,11]]}}}