{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:48:33Z","timestamp":1777452513634,"version":"3.51.4"},"reference-count":18,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Introduction: The use of medication has increased in recent years in the US while the use of dietary supplements has remained stable but high. Interactions between these two kinds of products may have important consequences, especially in the case of widely used medications such as antihypertensives and antibiotics. The aim of this paper is to estimate the prevalence of potentially serious drug\u2013dietary supplement interactions among tetracyclines, thiazides, and angiotensin II receptor blocker users by means of the NHANES 2013\u20132014 dataset. Methods: Data from 2013\u20132014 NHANES were obtained. Potential interactions analysed were tetracyclines with calcium, magnesium, and zinc, thiazides with vitamin D, and angiotensin II receptors blockers with potassium. Prevalence was calculated for each potential interaction. Logistic regression was used to assess associated factors. Results: 864 prescriptions issued to 820 patients were analysed. Overall prevalence of potential interaction was 49%. Older age and higher educational level were strongly associated with being at risk of a potential interaction. Factors such as age, race, civil status, citizenship, country of birth, BMI, and physical activity did not show notable associations. Conclusions: Healthcare professionals should be aware of other medical products when they prescribe or dispense a medication or a dietary supplement, especially to the older population and people with a higher educational level.<\/jats:p>","DOI":"10.3390\/nu11102466","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T03:32:54Z","timestamp":1571196774000},"page":"2466","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of Medication-Dietary Supplement Combined Use and Associated Factors"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-5968","authenticated-orcid":false,"given":"Ignacio","family":"Aznar-Lou","sequence":"first","affiliation":[{"name":"Teaching, Research &amp; Innovation Unit, Institut de Recerca Sant Joan de D\u00e9u, Esplugues de Llobregat, Parc Sanitari Sant Joan de D\u00e9u, 08830 Sant Boi de Llobregat (Barcelona), Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-5490","authenticated-orcid":false,"given":"Cristina","family":"Carbonell-Duacastella","sequence":"additional","affiliation":[{"name":"Teaching, Research &amp; Innovation Unit, Institut de Recerca Sant Joan de D\u00e9u, Esplugues de Llobregat, Parc Sanitari Sant Joan de D\u00e9u, 08830 Sant Boi de Llobregat (Barcelona), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Spanish Society of Community and Family Pharmacy (SEFAC), 28045 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In\u00e9s","family":"Mera","sequence":"additional","affiliation":[{"name":"Spanish Society of Community and Family Pharmacy (SEFAC), 28045 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2856-1697","authenticated-orcid":false,"given":"Maria","family":"Rubio-Valera","sequence":"additional","affiliation":[{"name":"Teaching, Research &amp; Innovation Unit, Institut de Recerca Sant Joan de D\u00e9u, Esplugues de Llobregat, Parc Sanitari Sant Joan de D\u00e9u, 08830 Sant Boi de Llobregat (Barcelona), Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Epidemiolog\u00eda y Salud P\u00fablica, CIBERESP, 28029 Madrid, Spain"},{"name":"School of Pharmacy, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1001\/jama.2015.13766","article-title":"Trends in prescription drug use among adults in the United States from 1999\u20132012","volume":"314","author":"Kantor","year":"2015","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/jama.2016.14403","article-title":"Trends in dietary supplement use among US adults from 1999\u20132012","volume":"316","author":"Kantor","year":"2016","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5001\/omj.2011.21","article-title":"Food-drug interactions","volume":"26","author":"Bushra","year":"2011","journal-title":"Oman Med. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1001\/jamainternmed.2015.8581","article-title":"Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 vs. 2011","volume":"176","author":"Qato","year":"2016","journal-title":"JAMA Intern. Med."},{"key":"ref_5","unstructured":"Pharma, E. (2009). Stockley Interacciones Farmacol\u00f3gicas (Stockley\u2019s Drug Interactions), Pharmaceutical Press. [3rd ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijcard.2017.04.104","article-title":"Dietary inflammatory potential is linked to cardiovascular disease risk burden in the US adult population","volume":"240","author":"Tyrovolas","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Malek, A.M., Newman, J.C., Hunt, K.J., and Marriott, B.P. (2019). Race\/Ethnicity, Enrichment\/Fortification, and Dietary Supplementation in the U.S. Population, NHANES 2009\u20132012. Nutrients, 11.","DOI":"10.3390\/nu11051005"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2165\/00002018-200730010-00007","article-title":"Risk factors associated with a high velocity of the development of hyperkalaemia in hospitalised patients","volume":"30","author":"Indermitte","year":"2007","journal-title":"Drug Saf."},{"key":"ref_9","unstructured":"Norwegian Insitute of Public Health WHO Collaborating Centre for Drug Statistics Methodology (2019, August 27). International Language for Drug Utilization Research. Available online:https:\/\/www.whocc.no\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cger.2014.04.008","article-title":"Substance abuse among older adults","volume":"30","author":"Kuerbis","year":"2014","journal-title":"Clin. Geriatr. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/j.1532-5415.2009.02329.x","article-title":"Concomitant use of prescription drugs and dietary supplements in ambulatory elderly people: Clinical investigations","volume":"57","author":"Nahin","year":"2009","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1001\/jama.2008.892","article-title":"Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States","volume":"300","author":"Qato","year":"2008","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Oktora, M.P., Denig, P., Bos, J.H.J., Schuiling-Veninga, C.C.M., and Hak, E. (2019). Trends in polypharmacy and dispensed drugs among adults in the Netherlands as compared to the United States. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214240"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"zsy264","DOI":"10.1093\/sleep\/zsy264","article-title":"Benzodiazepine and opioid co-usage in the US population, 1999\u20132014: An exploratory analysis","volume":"42","author":"Vozoris","year":"2019","journal-title":"Sleep"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1001\/jama.2016.13645","article-title":"US county-level trends in mortality rates for major causes of death, 1980\u20132014","volume":"316","author":"Stubbs","year":"2016","journal-title":"JAMA J. Am. Med. Assoc."},{"key":"ref_16","first-page":"e2741","article-title":"Prevalence of Vitamin D Deficiency and Associated Risk Factors in the US Population (2011\u20132012)","volume":"10","author":"Parva","year":"2018","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/07315724.2000.10718959","article-title":"The Effects of a Multivitamin\/Mineral Supplement on Micronutrient Status, Antioxidant Capacity and Cytokine Production in Healthy Older Adults Consuming a Fortified Diet","volume":"19","author":"McKay","year":"2000","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/10810730.2013.825668","article-title":"The relationship between health, education, and health literacy: Results from the dutch adult literacy and life skills survey","volume":"18","author":"Wang","year":"2013","journal-title":"J. Health Commun."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2466\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:26:24Z","timestamp":1760189184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/10\/2466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":18,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["nu11102466"],"URL":"https:\/\/doi.org\/10.3390\/nu11102466","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,15]]}}}