{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:13:14Z","timestamp":1771657994726,"version":"3.50.1"},"reference-count":87,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["27724\/2018-2 and 307564\/2017-7"],"award-info":[{"award-number":["27724\/2018-2 and 307564\/2017-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["555555 and 88881.172137\/2018-01"],"award-info":[{"award-number":["555555 and 88881.172137\/2018-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pr\u00f3-reitoria de Pesquisa da Universidade Federal do Par\u00e1 (PROPESP-UFPA)","award":["s\/n"],"award-info":[{"award-number":["s\/n"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 \u03bcL\/g) against MeHg i.p. exposure (2.5 mg\/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication.<\/jats:p>","DOI":"10.3390\/nu11112585","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T04:44:31Z","timestamp":1572237871000},"page":"2585","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit A\u00e7a\u00ed (Euterpe oleracea, Mart.) as Juice for Human Consumption"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-6853","authenticated-orcid":false,"given":"Maria Elena","family":"Crespo-L\u00f3pez","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericks Sousa","family":"Soares","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"},{"name":"Laboratory of Neurochemical Investigation, Center of Biological Sciences, Federal University of Santa, Catarina, Florian\u00f3polis\u2013SC 88040-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbarella de Matos","family":"Macchi","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Cellular Neurochemistry, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Santos-Sacramento","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Yuki","family":"Takeda","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Lopes-Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-2699","authenticated-orcid":false,"given":"Ricardo Sousa de Oliveira","family":"Paraense","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Rog\u00e9rio","family":"Souza-Monteiro","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4772-9929","authenticated-orcid":false,"given":"Marcus","family":"Augusto-Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"},{"name":"Laboratory of Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diandra Ara\u00fajo","family":"Luz","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior and Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-7375","authenticated-orcid":false,"given":"Cristiane do Socorro Ferraz","family":"Maia","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior and Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8925-8881","authenticated-orcid":false,"given":"Herv\u00e9","family":"Rogez","sequence":"additional","affiliation":[{"name":"Centre for Valorisation of Amazonian Bioactive Compounds (CVACBA) and Federal University of Par\u00e1, Bel\u00e9m-PA 66075-110, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3983-1672","authenticated-orcid":false,"given":"Marcelo de Oliveira","family":"Lima","sequence":"additional","affiliation":[{"name":"Evandro Chagas Institute, Secretary of 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UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,26]]},"reference":[{"key":"ref_1","first-page":"441","article-title":"Mercury and neurotoxicity","volume":"40","author":"Herculano","year":"2005","journal-title":"Rev. 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