{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:52:45Z","timestamp":1780372365572,"version":"3.54.1"},"reference-count":52,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n Cient\u00edfica Caja Rural de Soria","award":["2018"],"award-info":[{"award-number":["2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum levels of total calcium, phosphorus, intact parathyroid hormone, albumin, and 25-hydroxyvitaminD3 were analyzed. We also recruited data for QoL, physical activity, nutritional impairment, and muscular strength. Ninety percent of the subjects were classified as vitamin D deficient or insufficient. Participants with higher serum 25(OH)D3, calcium, phosphorous, and Alb levels were significantly less likely to self-report depression or anxiety after adjustment (p = 0.009, p = 0.005, p = 0.003, and p = 0.005, respectively). Additionally, we found an association between lower levels of albumin and self-reported problems with mobility or usual activities (p = 0.01). We also found associations between better muscle strength and higher levels of vitamin D, calcium, phosphorous, and albumin (p = 0.006, p = 0.003, p = 0.004 and p = 0.002, respectively). Overall, our data provide evidence that serum vitamin D and Alb levels are negatively related to self-reported anxiety or depression, usual activities, mobility, and three dimensions of QoL in older adults. Furthermore, vitamin D levels are positively related to hand grip strength in adults over 65 years old.<\/jats:p>","DOI":"10.3390\/nu11112748","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T09:11:27Z","timestamp":1573636287000},"page":"2748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bone Mineral Metabolism Status, Quality of Life, and Muscle Strength in Older People"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-7672","authenticated-orcid":false,"given":"Zoraida","family":"Verde","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Molecular Biology and Physiology, Universidad de Valladolid, Campus Duques de Soria, 42002 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giaquinta","sequence":"additional","affiliation":[{"name":"Department of Nursery, Universidad de Valladolid, Campus Duques de Soria, 42002 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Moreno Sainz","sequence":"additional","affiliation":[{"name":"Department of Clinic Biochemistry, Hospital Santa B\u00e1rbara, 42002 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"D\u00edaz Ondina","sequence":"additional","affiliation":[{"name":"Department of Clinic Biochemistry, Hospital Santa B\u00e1rbara, 42002 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-972X","authenticated-orcid":false,"given":"Ana","family":"Fern\u00e1ndez Araque","sequence":"additional","affiliation":[{"name":"Department of Nursery, Universidad de Valladolid, Campus Duques de Soria, 42002 Soria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.2310\/JIM.0b013e318214ea2d","article-title":"Vitamin D: A D-lightful solution for health","volume":"59","author":"Holick","year":"2011","journal-title":"J. Investig. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/9780470319444.ch9","article-title":"Calcium and Vitamin D","volume":"282","author":"Cashman","year":"2007","journal-title":"Novartis Found. Symp."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.pbiomolbio.2006.02.016","article-title":"Vitamin D physiology","volume":"92","author":"Lips","year":"2006","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mendes, J., Santos, A., Borges, N., Afonso, C., Moreira, P., Padr\u00e3o, P., Negr\u00e3o, R., and Amaral, T.F. (2018). Vitamin D status and functional parameters: A cross-sectional study in an older population. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201840"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kaur, J., Ferguson, S.L., Freitas, E., Miller, R., Bemben, D., Knehans, A., and Bemben, M. (2019). Association of vitamin d status with chronic disease risk factors and cognitive dysfunction in 50\u201370 year old adults. Nutrients, 11.","DOI":"10.3390\/nu11010141"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/s41430-018-0261-4","article-title":"Vitamin D: Past, present and future perspectives in the prevention of chronic diseases","volume":"79","author":"Muscogiuri","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Sondarwa, K., Buttar, R.S., Hensley, V., and Melamed, M.L. (2018). Vitamin D and Cardiovascular Disease. Contemporary Endocrinology, Humana Press Inc.","DOI":"10.1007\/978-3-319-73742-3_8"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.3390\/nu5061913","article-title":"Calcium regulation and bone mineral metabolism in elderly patients with chronic kidney disease","volume":"29","author":"Tejwani","year":"2013","journal-title":"Nutrients"},{"key":"ref_9","first-page":"362","article-title":"Calcium and vitamin D nutrition and bone disease of the elderly","volume":"11","author":"Bahlas","year":"2014","journal-title":"Life Sci. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11739-010-0407-4","article-title":"Vitamin D and health status in elderly","volume":"6","author":"Timpini","year":"2011","journal-title":"Intern. Emerg. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016","volume":"16","author":"Vos","year":"2017","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"172492","DOI":"10.1155\/2012\/172492","article-title":"Role of exercise therapy in prevention of decline in aging muscle function: Glucocorticoid myopathy and unloading","volume":"2012","author":"Seene","year":"2012","journal-title":"J. Aging Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chang, Y.W., Chen, W.L., Lin, F.G., Fang, W.H., Yen, M.Y., Hsieh, C.C., and Kao, T.W. (2012). Frailty and its impact on health-related quality of life: A cross-sectional study on elder community-dwelling preventive health service users. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038079"},{"key":"ref_14","unstructured":"Rabin, R., Oemar, M., Oppe, M., Janssen, B., and Herdman, M. (2015). EQ-5D-5L user guide. Basic Information How to Use EQ-5D-5L Instrument, EuroQol Research Foundation."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.3390\/ijerph10093967","article-title":"The physical activity scale for the elderly (PASE) questionnaire; Does it predict physical health?","volume":"10","author":"Logan","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_16","first-page":"388","article-title":"The Mini Nutritional Assessment (MNA) after 20 years of research and clinical practice","volume":"23","author":"Secher","year":"2008","journal-title":"Rev. Clin. Gerontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s40520-016-0628-0","article-title":"Predicting hand function in older adults: Evaluations of grip strength, arm curl strength, and manual dexterity","volume":"29","author":"Liu","year":"2017","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Massy-Westropp, N.M., Gill, T.K., Taylor, A.W., Bohannon, R.W., and Hill, C.L. (2011). Hand Grip Strength: Age and gender stratified normative data in a population-based study. BMC Res. Notes, 4.","DOI":"10.1186\/1756-0500-4-127"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/gerona\/glu011","article-title":"Grip strength cutpoints for the identification of clinically relevant weakness","volume":"69","author":"Alley","year":"2014","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.clinbiochem.2008.02.003","article-title":"Inappropriate serum levels of retinol, \u03b1-tocopherol, 25 hydroxyvitamin D3 and 24,25 dihydroxyvitamin D3 levels in healthy Spanish adults: Simultaneous assessment by HPLC","volume":"41","year":"2008","journal-title":"Clin. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4321\/S1889-836X2014000500002","article-title":"Deficiencia de vitamina D en Espa\u00f1a: \u00bfRealidad o mito?","volume":"6","year":"2014","journal-title":"Rev. Osteoporos. Metab. Miner."},{"key":"ref_22","first-page":"1079","article-title":"Vitamin D deficiency in Spain: A population-based cohort study","volume":"62","author":"Morcillo","year":"2011","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12","DOI":"10.18773\/austprescr.2015.004","article-title":"Measuring vitamin D","volume":"38","author":"Glendenning","year":"2015","journal-title":"Aust. Prescr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1524-4733.2006.00162.x","article-title":"Health-related quality of life measured with EQ-5D in patients treated for depression in primary care","volume":"10","author":"Sobocki","year":"2007","journal-title":"Value Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s11136-018-1877-5","article-title":"Validity of the EQ\u20135D\u20135L and reference norms for the Spanish population","volume":"27","author":"Hernandez","year":"2018","journal-title":"Qual. Life Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s11136-014-0696-6","article-title":"Vitamin D and health-related quality of life in a community sample of older Canadians","volume":"23","author":"Chao","year":"2014","journal-title":"Qual. Life Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s11136-011-9903-x","article-title":"Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)","volume":"20","author":"Herdman","year":"2011","journal-title":"Qual. Life Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00045391-200205000-00005","article-title":"Confounding by indication in epidemiologic studies of commonly used analgesics","volume":"9","author":"Signorello","year":"2002","journal-title":"Am. J. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1001\/archgenpsychiatry.2009.129","article-title":"Association of the Mediterranean dietary pattern with the incidence of depression: The Seguimiento Universidad de Navarra\/University of Navarra follow-up (SUN) cohort","volume":"66","author":"Alonso","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/PSY.0000000000000044","article-title":"Vitamin D supplementation for depressive symptoms: A systematic review and meta-analysis of randomized controlled trials","volume":"76","author":"Shaffer","year":"2014","journal-title":"Psychosom. Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Kimball, S.M., Mirhosseini, N., and Rucklidge, J. (2018). Database analysis of depression and anxiety in a community sample\u2014Response to a micronutrient intervention. Nutrients, 10.","DOI":"10.3390\/nu10020152"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1043-2760(01)00547-1","article-title":"New clues about vitamin D functions in the nervous system","volume":"13","author":"Garcion","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1471-4159.2005.03579.x","article-title":"Cross-talk of vitamin D and glucocorticoids in hippocampal cells","volume":"96","author":"Obradovic","year":"2006","journal-title":"J. Neurochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0169-328X(95)00314-I","article-title":"Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells","volume":"36","author":"Puchacz","year":"1996","journal-title":"Mol. Brain Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1196\/annals.1369.023","article-title":"Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine","volume":"1074","author":"Cass","year":"2006","journal-title":"Proc. Ann. N. Y. Acad. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1001\/archgenpsychiatry.2010.35","article-title":"High occurrence of mood and anxiety disorders among older adults: The National Comorbidity Survey Replication","volume":"67","author":"Byers","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/JGP.0b013e3181ad4f5a","article-title":"Prevalence of mood, anxiety, and substance-abuse disorders for older Americans in the national comorbidity survey-replication","volume":"17","author":"Gum","year":"2009","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1753-4887.2009.00220.x","article-title":"Vitamin D and the occurrence of depression: Causal association or circumstantial evidence?","volume":"67","year":"2009","journal-title":"Nutr. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1183\/09031936.00059814","article-title":"Ageing and the epidemiology of multimorbidity","volume":"44","author":"Divo","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.3390\/nu6041501","article-title":"Vitamin D and depression: A systematic review and meta-analysis comparing studies with and without biological flaws","volume":"6","author":"Spedding","year":"2014","journal-title":"Nutrients"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jamda.2018.06.011","article-title":"Sarcopenia and Low Serum Albumin Level Synergistically Increase the Risk of Incident Disability in Older Adults","volume":"20","author":"Uemura","year":"2019","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/ajcn\/64.4.552","article-title":"Serum albumin is associated with skeletal muscle in elderly men and women","volume":"64","author":"Baumgartner","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1532-5415.2005.53417.x","article-title":"Serum albumin and muscle strength: A longitudinal study in older men and women","volume":"53","author":"Schalk","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.physio.2005.05.003","article-title":"Reference values for adult grip strength measured with a Jamar dynamometer: A descriptive meta-analysis","volume":"92","author":"Bohannon","year":"2006","journal-title":"Physiotherapy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.abb.2010.05.029","article-title":"Hypophosphatemia is responsible for skeletal muscle weakness of vitamin D deficiency","volume":"500","author":"Schubert","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2796.2006.01685.x","article-title":"The prevalence of vitamin D inadequacy amongst women with osteoporosis: An international epidemiological investigation","volume":"260","author":"Lips","year":"2006","journal-title":"J. Intern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1111\/cen.13952","article-title":"Vitamin D is related to handgrip strength in adult men aged 50 years and over: A population study from the TCLSIH cohort study","volume":"90","author":"Wang","year":"2019","journal-title":"Clin. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kitsu, T., Kabasawa, K., Ito, Y., Kitamura, K., Watanabe, Y., Tanaka, J., Nakamura, K., and Narita, I. (2019). Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population. J. Bone Miner. Metab., 16.","DOI":"10.1007\/s00774-019-01040-w"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/CIRCHEARTFAILURE.114.001272","article-title":"Elevated parathyroid hormone, but not vitamin D deficiency, is associated with increased risk of heart failure in older men with and without cardiovascular disease","volume":"7","author":"Wannamethee","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pop.2008.01.007","article-title":"Disorders Involving Calcium, Phosphorus, and Magnesium","volume":"35","author":"Moe","year":"2008","journal-title":"Prim. Care Clin. Off. Pract."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.amjmed.2003.12.029","article-title":"Positive association between 25-hydroxy vitamin D levels and bone mineral density: A population-based study of younger and older adults","volume":"116","author":"Dietrich","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_52","first-page":"658","article-title":"Serum calcium and bone: Effect of PTH, phosphate, vitamin D and uremia","volume":"34","author":"Levine","year":"2014","journal-title":"Nefrologia"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/11\/2748\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:33:55Z","timestamp":1760189635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/11\/2748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,12]]},"references-count":52,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["nu11112748"],"URL":"https:\/\/doi.org\/10.3390\/nu11112748","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,12]]}}}