{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:44:31Z","timestamp":1790847871564,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"publisher","award":["E0164501-04"],"award-info":[{"award-number":["E0164501-04"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Geum japonicum, commonly known as Asian herb bennet, has been used as a diuretic, astringent, anti-dizziness, and anti-headache agent in traditional medicine. Since the antidepressant-like effects of G. japonicum extract have not been well studied, we examined the antidepressant-like effects of G. japonicum extract using depressive-like behavior induced in mice through daily injection of corticosterone (CORT). ICR mice (male, 8 weeks old) were treated with CORT (40 mg\/kg, i.p.) and orally administered using oral gavage needles with G. japonicum extract (30, 100, and 300 mg\/kg) for 4 weeks. Behavioral experiments were performed 1 h after administration. The control mice exhibited a significant increase in the immobility times in the tail suspension and forced swim tests as well as the step-through latency time in the passive avoidance test. Further, the control group showed a significant decrease in their sucrose consumption. However, treatment with G. japonicum extract at doses of 100 and 300 mg\/kg significantly improved these depression-like behaviors without altering the locomotor activity. Moreover, treatment with G. japonicum extract significantly prevented the decrease in the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. In addition, G. japonicum extract had neuroprotective effects against CORT-induced neurotoxicity in SH-SY5Y cells. Our study indicates that G. japonicum extract exhibits antidepressant-like activity in CORT-induced depressive mice, which might be as a result of increased BDNF expression.<\/jats:p>","DOI":"10.3390\/nu11122841","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T11:06:03Z","timestamp":1574247963000},"page":"2841","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Administration of Asian Herb Bennet (Geum japonicum) Extract Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2386-8414","authenticated-orcid":false,"given":"Dong Wook","family":"Lim","sequence":"first","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taewon","family":"Han","sequence":"additional","affiliation":[{"name":"Food Functional Evaluation Support Team, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Young","family":"Um","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"},{"name":"Division of Food Biotechnology, University of Science &amp; Technology, Daejeon 34113, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minseok","family":"Yoon","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3404-6977","authenticated-orcid":false,"given":"Yun Tai","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"},{"name":"Division of Food Biotechnology, University of Science &amp; Technology, Daejeon 34113, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeseok","family":"Han","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaekwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Division of Functional Food Functionality, Korea Food Research Institute, Wanju 55365, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/515180a","article-title":"Mental health: A world of depression","volume":"515","author":"Smith","year":"2014","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/YIC.0b013e3283311acd","article-title":"The pharmacological properties of antidepressants","volume":"25","author":"Racagni","year":"2010","journal-title":"Int. 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