{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T18:43:10Z","timestamp":1787856190159,"version":"build-2784847793"},"reference-count":58,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/20742-2; 2017\/15175-1; 2016\/22722-6; 2015\/18997-7; 2013\/07607-8"],"award-info":[{"award-number":["2017\/20742-2; 2017\/15175-1; 2016\/22722-6; 2015\/18997-7; 2013\/07607-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["BPQ2"],"award-info":[{"award-number":["BPQ2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>It was previously demonstrated that non-allergen-sensitized rodents born to mothers exposed to a high-fat diet (HFD) spontaneously develop lower respiratory compliance and higher respiratory resistance. In the present study, we sought to determine if mice born to mothers consuming HFD would exhibit changes in inflammatory response and lung remodeling when subjected to ovalbumin (OVA) sensitization\/challenge in adult life. Mice born to dams consuming either HFD or standard chow had increased bronchoalveolar lavage (BAL) levels of IL-1\u03b2, IL-4, IL-5, IL-10, IL-13, TNF-\u03b1 and TGF-\u03b21 after challenge with OVA. IL-4, IL-13, TNF-\u03b1 and TGF-\u03b21 levels were further increased in the offspring of HFD-fed mothers. Mice born to obese dams also had exacerbated values of leukocyte infiltration in lung parenchyma, eosinophil and neutrophil counts in BAL, mucus overproduction and collagen deposition. The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. Altogether, the present data support the unprecedented notion that the progeny of obese mice display exacerbated responses to sensitization\/challenge with OVA, leading to the intensification of the morphological changes of lung remodeling. Such changes are likely to result from long-lasting changes in miR-155 and miR-133b expression.<\/jats:p>","DOI":"10.3390\/nu11122902","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:50:45Z","timestamp":1575283845000},"page":"2902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8540","authenticated-orcid":false,"given":"Rodrigo Rodrigues","family":"e-Lacerda","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13083-881 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4951-1130","authenticated-orcid":false,"given":"Caio Jord\u00e3o","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13083-881 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0192-8869","authenticated-orcid":false,"given":"Silvana","family":"Bordin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Antunes","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13083-881 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7694-8397","authenticated-orcid":false,"given":"Gabriel Forato","family":"Anh\u00ea","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13083-881 Campinas, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1111\/cea.12963","article-title":"Increased prevalence of allergic asthma from 1996 to 2006 and further to 2016\u2014results from three population surveys","volume":"47","author":"Backman","year":"2017","journal-title":"Clin. 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