{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:36:05Z","timestamp":1790739365969,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T00:00:00Z","timestamp":1576281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Aging","award":["R01AG054057"],"award-info":[{"award-number":["R01AG054057"]}]},{"name":"National Institute of Aging","award":["R01AG054476"],"award-info":[{"award-number":["R01AG054476"]}]},{"name":"National Institute of Aging","award":["R01AG17917"],"award-info":[{"award-number":["R01AG17917"]}]},{"DOI":"10.13039\/100006760","name":"California Strawberry Commission","doi-asserted-by":"publisher","award":["940162-0120"],"award-info":[{"award-number":["940162-0120"]}],"id":[{"id":"10.13039\/100006760","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Strawberries have been identified to have antioxidant and anti-inflammatory properties that improve neuronal function and cognition, mostly in animal studies. It is unknown if the consumption of strawberries or related bioactives may reduce the risk of Alzheimer\u2019s dementia risk. Material and Methods: The study was conducted in 925 participants, aged 58\u201398 years of the Rush Memory and Aging Project. Participants were dementia-free at baseline, completed a food frequency questionnaire, and had at least two annual neurological evaluations. The diagnosis of Alzheimer\u2019s dementia was based on structured clinical neurological examination and standardized diagnostic criteria. The association of strawberry intake and incident Alzheimer\u2019s dementia was analyzed using proportional hazard models adjusted for age, sex, education, physical activity, participation in cognitive activities, APOE-\u025b4 genotype, dietary intake of other fruits, and total calorie intake. Results: A total of 245 participants developed Alzheimer\u2019s dementia over the mean follow-up of 6.7 (\u00b13.6) years. Higher strawberry intake was associated with reduced risk of Alzheimer\u2019s dementia (HR = 0.76, 95% CI: 0.60\u20130.96). In separate adjusted models, highest vs. lowest quartile intakes of Vitamin C (HR = 0.64, 95% CI: 0.45, 0.92), Pelargonidin (0.63, 95% CI: 0.43, 0.92), total anthocyanidins (0.69, 95% CI: 0.48, 0.99), and total flavonoids (0.67, 95% CI: 0.46, 0.98) were each associated with lower Alzheimer\u2019s dementia risk. These associations remained after further adjustment for cardiovascular conditions. Conclusion: Consumption of strawberries and foods rich in vitamin C, pelargonidin, anthocyanidins, and total flavonoids may reduce the risk of Alzheimer\u2019s dementia.<\/jats:p>","DOI":"10.3390\/nu11123060","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:19:38Z","timestamp":1576473578000},"page":"3060","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Association of Strawberries and Anthocyanidin Intake with Alzheimer\u2019s Dementia Risk"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-6653","authenticated-orcid":false,"given":"Puja","family":"Agarwal","sequence":"first","affiliation":[{"name":"Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-0194","authenticated-orcid":false,"given":"Thomas M","family":"Holland","sequence":"additional","affiliation":[{"name":"Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Wang","sequence":"additional","affiliation":[{"name":"Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Bennett","sequence":"additional","affiliation":[{"name":"Rush Alzheimer\u2019s Disease Center, Rush University Medical Center, Chicago, IL 60612, USA"},{"name":"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Clare","family":"Morris","sequence":"additional","affiliation":[{"name":"Rush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1037\/a0031196","article-title":"The influence of cognitive decline on well-being in old age","volume":"28","author":"Wilson","year":"2013","journal-title":"Psychol. 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