{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:53:50Z","timestamp":1760241230520,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T00:00:00Z","timestamp":1576368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Metabolic disturbances are among the most common disorders diagnosed in pediatric patients after anti-cancer therapy (ACT). The aim of our study was to evaluate the prevalence of metabolic disturbances among patients after ACT. The study group comprised 44 patients (31 boys) treated for solid tumors and 31 patients in the control group. Body weight, height, body mass index (BMI) values, lipid parameters are expressed in Standard Deviation Score (SDS), based on centile charts. Indicators of risk to atherosclerosis were calculated. Obesity\/overweight was observed in one third of the patients. Hypercholesterolemia occurred in half of them, elevated tryglicerides (TG) SDS in 11, and elevated low-density lipoprotein cholesterol (LDL-C) SDS in nine of the patients. Increased levels of both cholesterol SDS and LDL SDS were found in nine patients and four of them also showed elevated levels of TG SDS. There were significant differences in lipid parameters between the sexes. Risk indicators of lipid disorders defined by statistical distances (\u03c4) were determined for the study group and the control group. The sum of the risk ratios of lipid disorders in the study group was 150 times higher than in the control group. Patients after ACT require special monitoring of lipids profiles and thyroid function as they are at higher risk for dyslipidemia and atherosclerosis than healthy people.<\/jats:p>","DOI":"10.3390\/nu11123062","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T05:19:38Z","timestamp":1576473578000},"page":"3062","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Metabolic Disturbances in Children Treated for Solid Tumors"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7069-5026","authenticated-orcid":false,"given":"Ewa","family":"Barg","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Wroclaw Medical University, 50-560 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Po\u0142ubok","sequence":"additional","affiliation":[{"name":"Students\u2019 Science Society, Wroclaw Medical University, 50-560 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Hetman","sequence":"additional","affiliation":[{"name":"Students\u2019 Science Society, Wroclaw Medical University, 50-560 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Gonera","sequence":"additional","affiliation":[{"name":"Students\u2019 Science Society, Wroclaw Medical University, 50-560 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olimpia","family":"Jasielska","sequence":"additional","affiliation":[{"name":"Students\u2019 Science Society, Wroclaw Medical University, 50-560 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"S\u0119ga-Pondel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, 53-111 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Galant","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, 53-111 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernarda","family":"Kazanowska","sequence":"additional","affiliation":[{"name":"Department of Pediatric Bone Marrow Transplantation, Oncology and Hematology, Wroclaw Medical University, 53-111 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/pbc.25411","article-title":"Survivors of standard risk acute lymphoblastic leukemia do not have increased risk for overweight and obesity compared to non-cancer peers: A report from the Children\u2019s Oncology Group","volume":"62","author":"Lindemulder","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_2","first-page":"130","article-title":"Late effects of treatment of childhood cancer\u2014On the basis of the literature and own experience","volume":"17","year":"2013","journal-title":"Med. Wieku Rozw."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"647","DOI":"10.3122\/jabfm.2010.05.100031","article-title":"Lifetime follow-up care after childhood cancer","volume":"23","author":"Haddy","year":"2010","journal-title":"J. Am. Board Fam. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1002\/pbc.24703","article-title":"Metabolic syndrome in pediatric cancer survivors: A mechanistic review","volume":"60","author":"Rosen","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"A18","DOI":"10.1016\/j.clinthera.2012.12.014","article-title":"Childhood Obesity: A Review of Increased Risk for Physical and Psychological Comorbidities","volume":"35","year":"2013","journal-title":"Clin. Ther."},{"key":"ref_6","first-page":"144","article-title":"Thyroid abnormalities in survivors of childhood cancer","volume":"6","author":"Karadeniz","year":"2014","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.medici.2014.10.006","article-title":"Early development of endocrine and metabolic consequences after treatment of central nervous system tumors in children","volume":"50","author":"Labanauskas","year":"2014","journal-title":"Medicina"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1507\/endocrj.K08E-075","article-title":"Endocrinological analysis of 122 Japanese childhood cancer survivors in a single hospital","volume":"55","author":"Miyoshi","year":"2008","journal-title":"Endocr. J."},{"key":"ref_9","first-page":"1","article-title":"Ocena rozwoju somatycznego dzieci i m\u0142odzie\u017cy","volume":"3","author":"Palczewska","year":"2000","journal-title":"Med. Prakt."},{"key":"ref_10","first-page":"4","article-title":"St\u0119\u017cenie cholesterolu ca\u0142kowitego, cholesterolu frakcji HDL, LDL i VLDL oraz tr\u00f3jgliceryd\u00f3w w surowicy krwi u dzieci w r\u00f3\u017cnych grupach wieku","volume":"3","year":"1990","journal-title":"Pol. J. Paediatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jpeds.2011.08.018","article-title":"Cardiovascular risk and insulin resistance in childhood cancer survivors","volume":"160","author":"Steinberger","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/pbc.21363","article-title":"Metabolic syndrome traits in long-term survivors of pediatric sarcoma","volume":"50","author":"Derdak","year":"2008","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/1096-911X(200008)35:2<91::AID-MPO1>3.0.CO;2-G","article-title":"Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: Role of cranial irradiation","volume":"35","author":"Sklar","year":"2000","journal-title":"Med. Pediatr. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/cncr.29153","article-title":"Genetic and clinical factors associated with obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort","volume":"121","author":"Wilson","year":"2015","journal-title":"Cancer"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.18544\/PEDM-21.02.0025","article-title":"Evaluation of selected endocrine disorders after anticancer treatment of solid tumors in childhood","volume":"21","author":"Gonera","year":"2015","journal-title":"Pediatr. Endocrinol. Diabetes Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-2265.1999.00622.x","article-title":"Hyperleptinaemia in young adults following cranial irradiation in childhood: Growth hormone deficiency or leptin insensitivity?","volume":"50","author":"Brennan","year":"1999","journal-title":"Clin. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/pbc.21936","article-title":"Obesity and metabolic changes are common in young childhood brain tumor survivors","volume":"52","author":"Koivisto","year":"2009","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1210\/jc.2003-030784","article-title":"Final Height and Body Mass Index among Adult Survivors of Childhood Brain Cancer: Childhood Cancer Survivor Study","volume":"88","author":"Gurney","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.18544\/PEDM-23.02.0077","article-title":"Nutritional status at the moment of diagnosis in childhood cancer patients","volume":"23","author":"Malczewska","year":"2017","journal-title":"Pediatr. Endocrinol. Diabetes Metab."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3345\/kjp.2011.54.6.253","article-title":"The metabolic syndrome and body composition in childhood cancer survivors","volume":"54","author":"Sohn","year":"2011","journal-title":"Korean J. Pediatr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1203\/00006450-199507000-00015","article-title":"Obesity after successful treatment of acute lymphoblastic leukemia in childhood","volume":"38","author":"Tromp","year":"1995","journal-title":"Pediatr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/pbc.23280","article-title":"Dietary intake after treatment in child cancer survivors","volume":"58","author":"Cohen","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1210\/jc.2002-021797","article-title":"Obesity in Patients with Craniopharyngioma: Assessment of Food Intake and Movement Counts Indicating Physical Activity","volume":"88","author":"Harz","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.2012.113905","article-title":"Association of all-cause mortality with overweight and obesity using standard body mass index categories a systematic review and meta-analysis","volume":"309","author":"Flegal","year":"2013","journal-title":"J. Am. Med. Assoc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0002-8223(00)00022-5","article-title":"Functional status and emotional well-being, dietary intake, and physical activity of severely obese subjects","volume":"100","author":"Adams","year":"2000","journal-title":"J. Am. Diet. Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1158\/1055-9965.EPI-10-0163","article-title":"Characteristics and determinants of adiposity in pediatric cancer survivors","volume":"19","author":"Miller","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1158\/1055-9965.EPI-09-0555","article-title":"Cardiovascular risk factors in adult survivors of pediatric cancer-a report from the childhood cancer survivor study","volume":"19","author":"Meacham","year":"2010","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_28","first-page":"7495234","article-title":"Cardiovascular risk factors after childhood cancer treatment are independent of the FTO gene polymorphism?","volume":"2018","author":"Bernatowicz","year":"2018","journal-title":"Int. J. Endocrinol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1161\/CIR.0b013e3182a88099","article-title":"Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: Pathophysiology, course, monitoring, management, prevention, and research directions: A scientific statement from the American Heart Association","volume":"128","author":"Lipshultz","year":"2013","journal-title":"Circulation"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.ando.2018.07.011","article-title":"Expert opinion on the metabolic complications of new anticancer therapies: Tyrosine kinase inhibitors","volume":"79","author":"Buffier","year":"2018","journal-title":"Ann. Endocrinol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.15430\/JCP.2016.21.4.209","article-title":"Targeting Lipid Metabolic Reprogramming as Anticancer Therapeutics","volume":"21","author":"Cha","year":"2016","journal-title":"J. Cancer Prev."},{"key":"ref_32","first-page":"1025","article-title":"Evaluation of coronary artery disease by computed tomography angiography in patients treated for childhood Hodgkin\u2019s lymphoma","volume":"28","author":"Hazirolan","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1677\/ERC-10-0002","article-title":"Endocrine complications in long-term survivors of childhood cancers","volume":"17","author":"Chemaitilly","year":"2010","journal-title":"Endocr. Relat. Cancer"},{"key":"ref_34","first-page":"485","article-title":"Long-term effects of the treatment of malignant neoplasm in children","volume":"3","author":"Stefanowicz","year":"2009","journal-title":"Forum Med. Rodz."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0360-3016(02)02744-X","article-title":"Hypothyroidism in children with medulloblastoma: A comparison of 3600 and 2340 cGy craniospinal radiotherapy","volume":"53","author":"Paulino","year":"2002","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbcan.2018.01.004","article-title":"The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells","volume":"1869","author":"Libby","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ando.2018.07.007","article-title":"Expert opinion on thyroid complications in immunotherapy","volume":"79","author":"Illouz","year":"2018","journal-title":"Ann. Endocrinol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/12\/3062\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:42:32Z","timestamp":1760190152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/11\/12\/3062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,15]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["nu11123062"],"URL":"https:\/\/doi.org\/10.3390\/nu11123062","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2019,12,15]]}}}