{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:30:20Z","timestamp":1792290620008,"version":"4.4.0"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Italy is considered a mildly iodine-deficient country. The aim of this study was to evaluate the iodine status of a cohort of adults living in Liguria after the 2005 salt iodization program. We searched all medical records of patients examined in two endocrine outpatient clinics in Genoa and Savona for data on urinary iodine. Subjects were under evaluation for thyroid diseases. Information on the type of salt used was found in few clinical records. Iodized salt use was reported in 29%, 20%, and 13% of records of people living in Genoa districts, the Savona district and nearby districts, respectively. The average urinary iodine concentration was 112.9 \u00b1 62.3 \u00b5g\/L (n = 415, median 101.0 \u00b5g\/L). Non-significant differences (P &gt; 0.05) were found between subjects with (median 103.5 \u00b5g\/L) and without (median 97.5 \u00b5g\/L) a thyroid gland, between the periods 2009\u20132013 (median 105.0 \u00b5g\/L) and 2014\u20132018 (median 97.5 \u00b5g\/L), and between Genoa (median 94.0 \u00b5g\/L), Savona (median 105.0 \u00b5g\/L) and the other districts (median 114.5 \u00b5g\/L). No correlation with age, body mass index, creatinine, free thyroxine, thyroglobulin, levo-thyroxine dosage, or thyroid volume was observed. These data suggest a borderline status of iodine sufficiency in this cohort.<\/jats:p>","DOI":"10.3390\/nu12010011","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:50:33Z","timestamp":1576835433000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Urinary Iodine Concentration in a Cohort of Adult Outpatients with Thyroid Diseases in Liguria 14 Years after the Law on Salt Iodization"],"prefix":"10.3390","volume":"12","author":[{"given":"Lucia","family":"Conte","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"Endocrine Unit, San Martino Polyclinic Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Comina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"Endocrine Unit, San Martino Polyclinic Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Monti","sequence":"additional","affiliation":[{"name":"Endocrine Unit, San Martino Polyclinic Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Sidoti","sequence":"additional","affiliation":[{"name":"Endocrine Ambulatory, Centro Diagnostico Priamar, 17100 Savona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornella","family":"Vannozzi","sequence":"additional","affiliation":[{"name":"Laboratory Unit, San Martino Polyclinic Hospital, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Di Ciolo","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Santa Corona Hospital, Pietra Ligure, 17027 Savona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Lillo","sequence":"additional","affiliation":[{"name":"Laboratory Unit, Azienda Sanitaria Locale 2 of Liguria, 17100 Savona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Giusti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"},{"name":"Endocrine Unit, San Martino Polyclinic Hospital, 16132 Genoa, Italy"},{"name":"Endocrine Ambulatory, Centro Diagnostico Priamar, 17100 Savona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0140-6736(83)90636-0","article-title":"Iodine deficiency disorders (IDD) and their eradication","volume":"322","author":"Hetzel","year":"1983","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1001\/jama.2018.1291","article-title":"Iodine deficiency may impair fertility","volume":"319","author":"Khuen","year":"2018","journal-title":"Jama"},{"key":"ref_3","unstructured":"World Health Organization (2019, October 02). Report of sixty-third World Health Assembly. World Health Assembly Journal. Available online: https:\/\/apps.who.int\/gb\/ebwha\/pdf_files\/WHA63-REC1\/WHA63_REC1-en.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1079\/PHN2001138","article-title":"Iodine deficiency disorders in Europe","volume":"4","author":"Vitti","year":"2001","journal-title":"Public Health Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.23736\/S0026-4806.17.04877-7","article-title":"The way forward in Italy for iodine","volume":"108","author":"Olivieri","year":"2017","journal-title":"Minerva Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s40618-018-0838-8","article-title":"Continuously sustained elimination of iodine deficiency: A quarter of a century success in the Islamic Republic of Iran","volume":"41","author":"Delshad","year":"2018","journal-title":"J. Endocrinol. Investig."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1017\/S0007114517000733","article-title":"Decreased, but still sufficient, iodine intake of children and adults in the Netherlands","volume":"117","author":"Dekkers","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_8","unstructured":"Olivieri, A., and Vitti, P. (2019, October 02). Attivit\u00e0 di monitoraggio del programma nazionale per la prevenzione dei disordini da carenza iodica, Available online: http:\/\/www.salute.gov.it\/imgs\/C_17_pubblicazioni_2375_allegato.pdf pdf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ejcn.2013.44","article-title":"Iodine status in schoolchildren living in northeast Italy: The importance of the iodized-salt use and milk consumption","volume":"67","author":"Watutantrige","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_10","first-page":"414","article-title":"The iodine intake in a female population of an Appennine valley (Italy) in years 2003\u20132013","volume":"40","author":"Ozzola","year":"2016","journal-title":"Epidemiol. Prev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00394-015-0853-x","article-title":"Iodine status from childhood to adulthood in females living in North-East Italy: Iodine deficiency is still an issue","volume":"55","author":"Watutantrige","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.nut.2015.12.033","article-title":"Consumption of iodized salt may not represent a reliable indicator of iodine adequacy: Evidence from a cross-sectional study on schoolchildren living in an urban area of central Italy","volume":"32","author":"Coccaro","year":"2016","journal-title":"Nutrition"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nut.2017.11.007","article-title":"Iodine deficiency in pregnancy: Still a health issue for the women of Cassino city, Italy","volume":"50","author":"Tuccilli","year":"2018","journal-title":"Nutrition"},{"key":"ref_14","first-page":"54","article-title":"Iodoprofilassi 11 anni dopo: Progressi e prospettive","volume":"18","author":"Bagnasco","year":"2017","journal-title":"L\u2019Endocrinologo"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1093\/ajcn\/nqy393","article-title":"Iodine deficiency among Italian children and adolescents assessed through 24-hour urinary iodine excretion","volume":"109","author":"Campanozzi","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Musso, N., Conte, L., Carloni, B., Campana, C., Chiusano, M.C., and Giusti, M. (2018). Low-salt intake suggestions in hypertensive patients do not jeopardize urinary iodine excretion. Nutrients, 10.","DOI":"10.3390\/nu10101548"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF03346299","article-title":"Ultrasonography thyroid volume estimation in hyperthyroid patients treated with individual radioiodine dose","volume":"30","author":"Massaro","year":"2007","journal-title":"J. Endocrinol. Investig."},{"key":"ref_18","unstructured":"(2019, October 02). WHO Urinary iodine concentration for determining iodine status in population. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/85972\/WHO_NMH_NHD_EPG_13.1_eng.pdf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00394-015-0933-y","article-title":"Urinary iodine concentration of the New Zealand adults improves with mandatory fortification of bread with iodized salt but not to predicted level","volume":"55","author":"Edmonds","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"22837","DOI":"10.1002\/jcla.22837","article-title":"Iodine status of euthyroid adults: A cross-sectional, multicenter study","volume":"33","author":"Wang","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1530\/EJE-19-0212","article-title":"U-shaped relationship between iodine status and thyroid autoimmunity risk in adults","volume":"181","author":"Wang","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/thy.2018.0034","article-title":"Urinary iodine concentration and mortality among U.S. adults","volume":"28","author":"Inoue","year":"2018","journal-title":"Thyroid"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1017\/S0007114516004499","article-title":"Monitoring the effects of iodine prophylaxis in the adult population of southern Italy with deficient and sufficient iodine intake levels: A cross-sectional, epidemiological study","volume":"117","author":"Bonofiglio","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s40618-018-0938-5","article-title":"Poverty and immigration as a barrier to iodine intake and maternal adherence to iodine supplementation","volume":"42","author":"Magri","year":"2019","journal-title":"J. Endocrinol. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Charlton, K.E., Ware, L.J., Baumgartner, J., Cockeran, M., Schutte, A.E., Naidoo, N., and Kowal, P. (2018). Iodine status assessment in South African adults according to spot urinary iodine concentrations, prediction equations and measured 24 h iodine excretion. Nutrients, 10.","DOI":"10.3390\/nu10060736"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3945\/jn.115.215806","article-title":"24-Hour urine samples are more reproducible than spot urine samples for evaluation of iodine status in school-age children","volume":"146","author":"Chen","year":"2016","journal-title":"J. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:43:41Z","timestamp":1760190221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,19]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["nu12010011"],"URL":"https:\/\/doi.org\/10.3390\/nu12010011","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,19]]}}}