{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:59:27Z","timestamp":1787029167016,"version":"build-2736575974"},"reference-count":58,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2015\/17\/B\/NZ9\/03 581"],"award-info":[{"award-number":["2015\/17\/B\/NZ9\/03 581"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Cichoric acid (CA) belongs to the group of polyphenols, which occurs in a variety of plant species and it is characterized by anticancer, antibacterial, and antiviral properties. Selected polyphenols have the ability to combine with metal ions to form chelate complexes that reveal greater biological activity than free compounds. In order to study possible antimicrobial and anticancer effect of CA and its complexes with copper(II)\/zinc(II)\/nickel(II)\/cobalt(II) we decided to conduct cytotoxicity tests to estimate the most effective concentrations of tested compounds. The results of the presented study demonstrated, for the first time, that the treatment with newly synthesized CA-metal complexes has anticancer and antimicrobial effects, which were examined in seven different cell lines: MCF-7, MDA-MB-231, and ZR-75-1 breast cancer cell lines, A375 melanoma cell line, DLD-1 cell line, LN-229 cell line, FN cell line; five bacterial strains: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Proteus vulgaris, Lactobacillus rhamnosus, yeast Sacchcaromyces boulardii, and pathogenic yeast-like fungi Candida albicans. The presented study indicates that CA-metal complexes could be considered as a potential supplementary tool in anticancer therapy, however, because of their possible toxic activity on fibroblasts, they should be used with caution. Some of the tested complexes have also preservative properties and positive influence on normal non-pathogenic microorganisms, which was demonstrated in selected microbial strains, therefore they may serve as food preservatives of natural origin with cytoprotective properties.<\/jats:p>","DOI":"10.3390\/nu12010154","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T10:34:46Z","timestamp":1578306886000},"page":"154","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Biological Activity of New Cichoric Acid\u2013Metal Complexes in Bacterial Strains, Yeast-Like Fungi, and Human Cell Cultures In Vitro"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7711-3017","authenticated-orcid":false,"given":"Agata","family":"Jab\u0142o\u0144ska-Trypu\u0107","sequence":"first","affiliation":[{"name":"Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-435X","authenticated-orcid":false,"given":"Urszula","family":"Wydro","sequence":"additional","affiliation":[{"name":"Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8390-2947","authenticated-orcid":false,"given":"El\u017cbieta","family":"Wo\u0142ejko","sequence":"additional","affiliation":[{"name":"Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"\u015awiderski","sequence":"additional","affiliation":[{"name":"Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u0142odzimierz","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Division of Chemistry, Biology and Biotechnology, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fchem.2013.00040","article-title":"Chicoric acid: Chemistry, distribution, and production","volume":"1","author":"Lee","year":"2013","journal-title":"Front. Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/1-4020-4447-X_9","article-title":"Antimicrobial and nematicidal substances from the root of chicory (Cichorium intybus)","volume":"2","author":"Nishimura","year":"2006","journal-title":"Allelochem. Biol. Control Plant Pathog. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plaphy.2013.05.009","article-title":"Plant phenolics: Recent advances on their biosynthesis, genetics, and ecophysiology","volume":"72","author":"Cheynier","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1211\/0022357056127","article-title":"Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): A review of their chemistry, pharmacology and clinical properties","volume":"57","author":"Barnes","year":"2005","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1080\/09168451.2018.1451742","article-title":"Chicoric acid mitigates impaired insulin sensitivity by improving mitochondrial function","volume":"82","author":"Kim","year":"2018","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.fct.2017.06.041","article-title":"Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice","volume":"107","author":"Zhu","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29600","DOI":"10.18632\/oncotarget.16768","article-title":"Chicoric acid is a potent anti-atherosclerotic ingredient by anti-oxidant action and anti-inflammation capacity","volume":"8","author":"Tsai","year":"2017","journal-title":"Oncotarget"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1007\/s00284-017-1310-2","article-title":"Antimicrobial Activity of Selected Polyphenols and Capsaicinoids Identified in Pepper (Capsicum annuum L.) and Their Possible Mode of Interaction","volume":"74","author":"Mokhtar","year":"2017","journal-title":"Curr. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20120519","DOI":"10.1098\/rsta.2012.0519","article-title":"Photoactivatable Metal Complexes: From Theory to Applications in Biotechnology and Medicine","volume":"371","author":"Smith","year":"2013","journal-title":"Philos. Trans. R. Soc. A"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jinorgbio.2014.07.007","article-title":"Behavior of the potential antitumor V(IV)O complexes formed by flavonoid ligands. 1. Coordination modes and geometry in solution and at the physiological pH","volume":"140","author":"Sanna","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jinorgbio.2015.07.018","article-title":"Behavior of the potential antitumor V(IV)O complexes formed by flavonoid ligands. 2. Characterization of sulfonate derivatives of quercetin and morin, interaction with the bioligands of the plasma and preliminary biotransformation studies","volume":"153","author":"Sanna","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jinorgbio.2016.04.027","article-title":"Behavior of the potential antitumor V(IV)O complexes formed by flavonoid ligands. 3. Antioxidant properties and radical production capability","volume":"161","author":"Sanna","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Leone, A., and Mercer, J.F.B. (1999). Copper Transport and Its Disorders, Molecular and Cellular Aspects, Springer Science & Business Media.","DOI":"10.1007\/978-1-4615-4859-1"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jinorgbio.2017.12.006","article-title":"Physicochemical, antioxidant, DNA cleaving properties and antimicrobial activity of fisetin-copper chelates","volume":"180","author":"Pilo","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s11095-010-0055-4","article-title":"Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: A putative mechanism for chemoprevention of cancer","volume":"27","author":"Hadi","year":"2010","journal-title":"Pharm. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jtemb.2017.08.002","article-title":"Oleuropein shows copper complexing properties and noxious effect on cultured SH-SY5Y neuroblastoma cells depending on cell copper content","volume":"44","author":"Capo","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_17","first-page":"1673","article-title":"Does the combination of resveratrol with Al (III) and Zn (II) improve its antioxidant activity?","volume":"6","author":"Dias","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1021\/acs.jpcb.8b08284","article-title":"Kaempferol Binding to Zinc(II), Efficient Radical Scavenging through Increased Phenol Acidity","volume":"122","author":"Xu","year":"2018","journal-title":"J. Phys. Chem. B"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jinorgbio.2009.11.008","article-title":"Syntheses, characterization and antitumor activities of transition metal complexes with isoflavones","volume":"104","author":"Chen","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1023\/A:1007128325639","article-title":"Metal complexes of the flavonoid quercetin: Antibacterial properties","volume":"26","author":"Bravo","year":"2001","journal-title":"Transit. Met. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0162-0134(00)00128-8","article-title":"Synthesis, characterization, antioxidative and antitumor activities of solid quercetin rare earth(III) complexes","volume":"83","author":"Zhou","year":"2001","journal-title":"J. Inorg. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ska-Trypu\u0107, A., Kr\u0119towski, R., Kalinowska, M., \u015awiderski, G., Cechowska-Pasko, M., and Lewandowski, W. (2018). Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid\u2014Antioxidant Nutrient. Nutrients, 10.","DOI":"10.3390\/nu10010044"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"\u015awis\u0142ocka, R., Regulska, E., Karpi\u0144ska, J., \u015awiderski, G., and Lewandowski, W. (2019). Molecular Structure and Antioxidant Properties of Alkali Metal Salts of Rosmarinic Acid. Experimental and DFT Studies. Molecules, 24.","DOI":"10.3390\/molecules24142645"},{"key":"ref_24","unstructured":"Frisch, M., Trucks, G.W., Schlegel, H.B., Scuseria, G.E., Robb, M.A., Cheeseman, J.R., Scalmani, G., Barone, V., Mennucci, B., and Petersson, G.A. (2009). Gaussian 09, Revision A. 02, Gaussian Inc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.18632\/oncotarget.6812","article-title":"Chicoric acid binds to two sites and decreases the activity of the YopH bacterial virulence factor","volume":"7","author":"Sahu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1365-2672.2003.01801.x","article-title":"Influence of phenolic acids on growth and inactivation of Oenococcus oeni and Lactobacillus hilgardii","volume":"94","author":"Campos","year":"2003","journal-title":"J. Appl. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wu, Y., Bai, J., Zhong, K., Huang, Y., Qi, H., Jiang, Y., and Gao, H. (2016). Antibacterial Activity and Membrane-Disruptive Mechanism of 3-p-trans-Coumaroyl-2-hydroxyquinic Acid, a Novel Phenolic Compound from Pine Needles of Cedrus deodara, against Staphylococcus aureus. Molecules, 21.","DOI":"10.3390\/molecules21081084"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.fct.2019.05.007","article-title":"Phenolic composition, antioxidant and antibacterial properties, and in vitro anti-HepG2 cell activities of wild apricot (Armeniaca Sibirica L. Lam) kernel skins","volume":"129","author":"Qin","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.saa.2012.12.018","article-title":"Synthesis and characterization of binary and ternary complexes of Co(II), Ni(II), Cu(II) and Zn(II) ions based on 4-aminotoluene-3-sulfonic acid","volume":"105","author":"Faheim","year":"2013","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1007\/s11694-019-00210-8","article-title":"Extraction of phenolic antioxidants from Pyrus elaeagrifolia Pallas: Process optimization, investigation of the bioactivity and \u03b2-glucuronidase inhibitory potential","volume":"13","author":"Kavak","year":"2019","journal-title":"J. Food Meas. Charact."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103337","DOI":"10.1016\/j.bioorg.2019.103337","article-title":"Antibacterial, antifungal and antioxidant activity of total polyphenols of Withania frutescens.L","volume":"93","author":"Almehdi","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1472-765X.2012.03248.x","article-title":"Antibacterial activity of wine phenolic compounds and oenological extracts against potential respiratory pathogens","volume":"54","author":"Cueva","year":"2012","journal-title":"Lett. Appl. Microb."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1016\/j.bbamem.2013.07.029","article-title":"structure\u2013activity relationship study of flavonoids as inhibitors of E. coli by membrane interaction effect","volume":"1828","author":"Wu","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.foodcont.2011.11.022","article-title":"p-coumaric acid kills bacteria through dual damage mechanisms","volume":"25","author":"Lou","year":"2012","journal-title":"Food Control"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S2222-1808(14)60464-3","article-title":"Antibacterial synergy between quercetin and polyphenolic acids against bacterial pathogens of fish","volume":"4","author":"Prasad","year":"2014","journal-title":"Asian Pac. J. Trop. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11562","DOI":"10.1038\/s41598-019-47978-9","article-title":"Intelligent Metal-Phenolic Metallogels as Dressings for Infected Wounds","volume":"9","author":"Anh","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9777","DOI":"10.1038\/s41598-019-46224-6","article-title":"Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole","volume":"9","author":"Ciepluch","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_38","first-page":"2334","article-title":"Metal complex derivatives of azole: A study on their synthesis, characterization, and antibacterial and antifungal activities","volume":"27","author":"Castillo","year":"2016","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/21505594.2016.1188236","article-title":"The synthesis, regulation, and functions of sterols in Candida albicans: Well-known but still lots to learn","volume":"7","author":"Lv","year":"2016","journal-title":"Virulence"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Murcia, R.A., Leal, S.M., Roa, M.V., Nagles, E., Mu\u00f1oz-Castro, A., and Hurtado, J.J. (2018). Development of Antibacterial and Antifungal Triazole Chromium(III) and Cobalt(II) Complexes: Synthesis and Biological Activity Evaluations. Molecules, 13.","DOI":"10.3390\/molecules23082013"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0003-2670(02)00572-X","article-title":"Gas chromatographic\u2013tandem mass spectrometric identification of phenolic compounds in Sicilian olive oils","volume":"466","author":"Saitta","year":"2002","journal-title":"Anal. Chim. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.59566\/IJBS.2008.4089","article-title":"Free radicals, antioxidants in disease and health","volume":"4","author":"He","year":"2008","journal-title":"Int. J. Biomed. Sci."},{"key":"ref_43","first-page":"5177","article-title":"A systematic review of the efficacy of bioactive compounds in cardiovascular disease: Phenolic compounds","volume":"29","author":"Aguilera","year":"2015","journal-title":"Nutrients"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2174\/187152012802650075","article-title":"Flavonoids in cancer prevention","volume":"12","author":"Park","year":"2012","journal-title":"Anti-Cancer Agents Med. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.fitote.2011.01.018","article-title":"Antioxidant and prooxidant properties of flavonoids","volume":"82","author":"Prochazkova","year":"2011","journal-title":"Fitoterapia"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0076-6879(01)35243-6","article-title":"Metal chelation of polyphenols","volume":"335","author":"Hider","year":"2001","journal-title":"Methods Enzymol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/ptr.5643","article-title":"Prooxidant Activity of Polyphenols, Flavonoids, Anthocyanins and Carotenoids: Updated Review of Mechanisms and Catalyzing Metals","volume":"30","author":"Eghbaliferiz","year":"2016","journal-title":"Phytother. Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0044-8486(96)01503-7","article-title":"Trace minerals in fish nutrition","volume":"151","author":"Watanabe","year":"1997","journal-title":"Aquaculture"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1016\/j.febslet.2005.04.077","article-title":"Resveratrol\u2013Cu (II) induced DNA breakage in human peripheral lymphocytes: Implications for anticancer properties","volume":"579","author":"Azmi","year":"2005","journal-title":"FEBS Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"982","DOI":"10.37358\/RC.08.9.1952","article-title":"Manganese and zinc overdose-risk of oxidative stress appearance","volume":"59","author":"Ahmadi","year":"2008","journal-title":"Rev. Chim."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00008390-199712000-00002","article-title":"Cytotoxic interactions of Zn2+ in vitro: Melanoma cells are more susceptible than melanocytes","volume":"7","author":"Borovansky","year":"1997","journal-title":"Melanoma Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1034\/j.1600-0749.2003.00046.x","article-title":"Melanin as a target for melanoma chemotherapy: Pro-oxidant effect of oxygen and metals on melanoma viability","volume":"16","author":"Farmer","year":"2003","journal-title":"Pigment Cell Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1023\/A:1025418332121","article-title":"Spectroscopic and voltammetric studies of the cobalt (II) complex of Morin bound to calf thymus DNA","volume":"28","author":"Song","year":"2003","journal-title":"Transit. Met. Chem."},{"key":"ref_54","first-page":"59","article-title":"Metal Ion Complex -Potential Anticancer Drug- A Review","volume":"4","author":"Baile","year":"2015","journal-title":"IJPRR"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/ecam\/neh118","article-title":"Echinacea: A miracle herb against aging and cancer? Evidence in vivo in mice","volume":"2","author":"Miller","year":"2005","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1021\/jf500319h","article-title":"Bioavailability of hydroxycinnamic acids from Crepidiastrum denticulatum using simulated digestion and Caco-2 intestinal cells","volume":"23","author":"Lee","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.ccr.2006.11.017","article-title":"Using coordination chemistry to design new Medicines","volume":"251","author":"Ronconi","year":"2007","journal-title":"Coord. Chem. Rev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3390\/12071352","article-title":"Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity","volume":"12","author":"Pereira","year":"2007","journal-title":"Molecules"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/1\/154\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:03:42Z","timestamp":1760364222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/1\/154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,6]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["nu12010154"],"URL":"https:\/\/doi.org\/10.3390\/nu12010154","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,6]]}}}