{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:22:28Z","timestamp":1783970548070,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The frequency of celiac disease (CD) has increased along time, with relevant changes reported in geographical variations, clinical presentation and nutritional repercussions. In recent years, some celiac patients are presenting overweight\/obesity, but it is unclear how frequent this is and to what extent undernutrition remains a concern. This is relevant because CD tends to be overlooked in overweight patients. With this in mind, we assessed age at diagnosis, clinical characteristics and nutritional status of 155 celiac patients diagnosed between 1994\u20132017 in four pediatric hospitals in Santiago, Chile. Since 2003, the number of patients diagnosed has increased (p &lt; 0.0033), coinciding with antitransglutaminase and antiendomysial antibodies becoming available to public health systems. In 2000, 4.5% of patients were asymptomatic at diagnosis, suggesting that active search is not routinely applied. Gastrointestinal symptoms plus failure to thrive were significantly more frequent under 2 years (p = 0.0001). Nutritional status has improved at diagnosis and during follow up, but undernutrition remains more frequent in children &lt;2 and &lt;5 years (p &lt; 0.002 and p &lt; 0.0036, respectively). Overweight at diagnosis was reported in 2002 and obesity in 2010. After initiating treatment, since 2010, patients changing from undernourishment to overweight has sometimes been observed after only 6 months on a gluten-free diet.<\/jats:p>","DOI":"10.3390\/nu12010156","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T10:34:46Z","timestamp":1578306886000},"page":"156","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Changes in Age at Diagnosis and Nutritional Course of Celiac Disease in the Last Two Decades"],"prefix":"10.3390","volume":"12","author":[{"given":"M\u00f3nica","family":"Villanueva","sequence":"first","affiliation":[{"name":"Fellow, Pediatric Gastroenterology and Nutrition Program, Faculty of Medicine, University of Chile, Santiago, Chile, Cl\u00ednica Alemana de Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaya","family":"Oyarz\u00fan","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4569-3843","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Leyton","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Hospital Roberto del R\u00edo, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Navarro","sequence":"additional","affiliation":[{"name":"Hospital Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Canales","sequence":"additional","affiliation":[{"name":"Hospital Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobal","family":"Ossa","sequence":"additional","affiliation":[{"name":"Hospital Luis Calvo Mackenna, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Paz","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Hospital Luis Calvo Mackenna, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla A.","family":"Bascu\u00f1\u00e1n","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile"},{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Araya","sequence":"additional","affiliation":[{"name":"Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(03)14027-5","article-title":"Coeliac disease","volume":"362","author":"Green","year":"2003","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0140-6736(17)31796-8","article-title":"Coeliac disease","volume":"391","author":"Lebwohl","year":"2018","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1111\/j.1572-0241.2006.00750.x","article-title":"Overweight in celiac disease: Prevalence, clinical characteristics, and effect of a gluten-free diet","volume":"101","author":"Dickey","year":"2006","journal-title":"Am. 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