{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:54:19Z","timestamp":1790171659007,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T00:00:00Z","timestamp":1578873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Alzheimer\u2019s disease (AD), the most threatening neurodegenerative disease, is characterized by the loss of memory and language function, an unbalanced perception of space, and other cognitive and physical manifestations. The pathology of AD is characterized by neuronal loss and the extensive distribution of senile plaques and neurofibrillary tangles (NFTs). The role of environment and the diet in AD is being actively studied, and nutrition is one of the main factors playing a prominent role in the prevention of neurodegenerative diseases. In this context, the relationship between dementia and wine use\/abuse has received increased research interest, with varying and often conflicting results. Scope and Approach: With this review, we aimed to critically summarize the main relevant studies to clarify the relationship between wine drinking and AD, as well as how frequency and\/or amount of drinking may influence the effects. Key Findings and Conclusions: Overall, based on the interpretation of various studies, no definitive results highlight if light to moderate alcohol drinking is detrimental to cognition and dementia, or if alcohol intake could reduce risk of developing AD.<\/jats:p>","DOI":"10.3390\/nu12010206","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T03:20:22Z","timestamp":1579058422000},"page":"206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Relationship of Wine Consumption with Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Marcella","family":"Reale","sequence":"first","affiliation":[{"name":"Deptartment of Medical, Oral and Biotechnological Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 65100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-4226","authenticated-orcid":false,"given":"Erica","family":"Costantini","sequence":"additional","affiliation":[{"name":"Deptartment of Medical, Oral and Biotechnological Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 65100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas","family":"Jagarlapoodi","sequence":"additional","affiliation":[{"name":"Deptartment of Medical, Oral and Biotechnological Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 65100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Belwal","sequence":"additional","affiliation":[{"name":"College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310027, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Cichelli","sequence":"additional","affiliation":[{"name":"Deptartment of Medical, Oral and Biotechnological Sciences, University \u201cG. d\u2019Annunzio\u201d Chieti-Pescara, 65100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,13]]},"reference":[{"key":"ref_1","unstructured":"Norrie, P. (2018). The History of Wine as a Medicine: From Its Beginnings in China to the Present Day, Cambridge Scholars Publishing."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/anie.201000044","article-title":"Plant polyphenols: Chemical properties, biological activities and synthesis","volume":"17","author":"Quideau","year":"2011","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jff.2017.10.047","article-title":"Antioxidant and anti-inflammatory activities of quercetin and its derivatives","volume":"40","author":"Lesjak","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Salehi, B., Mishra, A.P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., Fokou, P.V.T., Martins, N., and Sharifi-Rad, J. (2018). Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines, 9.","DOI":"10.3390\/biomedicines6030091"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Khan, H., Reale, M., Ullah, H., Sureda, A., Tejada, S., Wang, Y., Zhang, Z.-J., and Xiao, J. (2019). Anti-cancer effects of polyphenols via targeting p53 signaling pathway: Updates and future directions. Biotechnol. Adv.","DOI":"10.1016\/j.biotechadv.2019.04.007"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.autrev.2019.05.001","article-title":"Polyphenols in the treatment of autoimmune diseases","volume":"18","author":"Khan","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.pharmthera.2018.09.009","article-title":"The role of flavonoids in autoimmune diseases: Therapeutic updates","volume":"194","author":"Rengasamy","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fphar.2018.00422","article-title":"Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing","volume":"9","author":"Ullah","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/2047-9158-2-6","article-title":"Traditional Chinese medicine: A promising candidate for the treatment of Alzheimer\u2019s disease","volume":"2","author":"Sun","year":"2013","journal-title":"Transl. Neurodegener."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0924-2244(01)00080-2","article-title":"The wine proteins","volume":"12","author":"Ferreira","year":"2001","journal-title":"Trends Food Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.microc.2015.03.011","article-title":"Establishment of influence the nitrogen content in musts and volatile profile of white wines associated to chemometric tools","volume":"122","author":"Burin","year":"2015","journal-title":"Microchem. J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cheung, P., and Mehta, B. (2014). Chemical Composition of Beverages and Drinks. Handbook of Food Chemistry, Springer.","DOI":"10.1007\/978-3-642-41609-5"},{"key":"ref_13","unstructured":"(2020, January 12). Dietary Guidelines for Americans, 2015\u20132020, Available online: https:\/\/health.gov\/dietaryguidelines\/2015\/guidelines\/."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ahj.2007.08.009","article-title":"Interactions of wine drinking with omega-3 fatty acids in patients with coronary heart disease: A fish-like effect of moderate wine drinking","volume":"155","author":"Salen","year":"2008","journal-title":"Am. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yjmcc.2011.10.011","article-title":"Moderate ethanol ingestion and cardiovascular protection: From epidemiologic associations to cellular mechanisms","volume":"52","author":"Krenz","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-0030-1248725","article-title":"Moderate Red Wine Consumption and Cardiovascular Disease Risk: Beyond the \u201cFrench Paradox\u201d","volume":"36","author":"Lippi","year":"2010","journal-title":"Semin. Thrombosis Hemostasis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1017\/S0007114513002845","article-title":"Consumption of alcoholic beverages and cognitive decline at middle age: The Doetinchem Cohort Study","volume":"111","author":"Nooyens","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4067\/S0716-97602004000200003","article-title":"Risk of dementia and alcohol and wine consumption: A review of recent results","volume":"37","author":"Letenneur","year":"2004","journal-title":"Biol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3390\/ijms11020622","article-title":"Biological activities of polyphenols from grapes","volume":"11","author":"Xia","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0963-9969(00)00071-5","article-title":"Wine by-products with health benefits","volume":"33","author":"Shrikhande","year":"2000","journal-title":"Food Res. Intern."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3233\/NUA-150055","article-title":"Wine consumption, cognitive function and dementias\u2014A relationship?","volume":"3","author":"Stockley","year":"2015","journal-title":"Nutr. Aging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/adb.12364","article-title":"Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment","volume":"22","author":"Vetreno","year":"2017","journal-title":"Addict. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1192\/bjp.bp.108.051425","article-title":"Alcohol-related dementia: A 21st-century silent epidemic?","volume":"193","author":"Gupta","year":"2008","journal-title":"Br. J. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/mp.2016.25","article-title":"Alcohol affects brain functional connectivity and its coupling with behavior: Greater effects in male heavy drinkers","volume":"22","author":"Tomasi","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_25","first-page":"151","article-title":"Alcohol and Alzheimer\u2019s Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer\u2019s Disease?","volume":"52","author":"Venkataraman","year":"2017","journal-title":"Alcohol Alcohol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/539179a","article-title":"Neurodegenerative diseases","volume":"539","author":"Heemels","year":"2016","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuro.2017.03.006","article-title":"Risk factors associated with the onset and progression of Alzheimer\u2019s disease: A systematic review of the evidence","volume":"61","author":"Hersi","year":"2017","journal-title":"Neurotoxicology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2174\/156720512800492549","article-title":"Relationship between inflammatory mediators, A\u03b2 levels and ApoE genotype in Alzheimer disease","volume":"9","author":"Reale","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.2174\/1567205014666170203141717","article-title":"Neuroinflammation and Alzheimer\u2019s disease: Implications for microglial activation","volume":"14","author":"Regen","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1001\/archneurol.2007.56","article-title":"Protein misfolding and neurodegeneration","volume":"65","author":"Soto","year":"2008","journal-title":"Arch. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/JGP.0b013e3181953b82","article-title":"Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults","volume":"17","author":"Lavretsky","year":"2009","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer\u2019s disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"ref_35","first-page":"974026","article-title":"Neuroinflammation, AD, and Dementia","volume":"2010","author":"Reale","year":"2010","journal-title":"Int. J. Alzheimers Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.exger.2004.12.003","article-title":"Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer\u2019s disease patients","volume":"40","author":"Reale","year":"2005","journal-title":"Exp. Gerontol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.exger.2005.04.007","article-title":"Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer\u2019s disease","volume":"40","author":"Iarlori","year":"2005","journal-title":"Exp. Gerontol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/354432a0","article-title":"Alzheimer\u2019s disease. In the beginning","volume":"354","author":"Selkoe","year":"1991","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S1474-4422(19)30202-9","article-title":"\u03b2-secretase inhibitors for Alzheimer\u2019s disease: Heading in the wrong direction?","volume":"18","author":"Selkoe","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8590578","DOI":"10.1155\/2016\/8590578","article-title":"The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer\u2019s Disease, Parkinson\u2019s Disease, and Huntington\u2019s Disease: A Mini Review","volume":"2016","author":"Manoharan","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1111\/bph.14585","article-title":"Mitochondrial dysfunction in Alzheimer\u2019s disease: Role in pathogenesis and novel therapeutic opportunities","volume":"176","author":"Swerdlow","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wojsiat, J., Zoltowska, KM., Laskowska-Kaszub, K., and Wojda, U. (2018). Oxidant\/Antioxidant Imbalance in Alzheimer\u2019s Disease: Therapeutic and Diagnostic Prospects. Oxid. Med. Cell. Longev.","DOI":"10.1155\/2018\/6435861"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12974-016-0530-x","article-title":"Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research","volume":"13","author":"Parimisetty","year":"2016","journal-title":"J. Neuroinflamm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s12017-012-8201-2","article-title":"Decreased levels of circulating adiponectin in mild cognitive impairment and Alzheimer\u2019s disease","volume":"15","author":"Teixeira","year":"2013","journal-title":"Neuromol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"k2927","DOI":"10.1136\/bmj.k2927","article-title":"Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study","volume":"362","author":"Sabia","year":"2018","journal-title":"Br. Med. J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.clineuro.2005.06.005","article-title":"A 2-year follow-up study of alcohol consumption and risk of dementia","volume":"108","author":"Deng","year":"2006","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1440-1819.2008.01904.x","article-title":"Alcohol consumption and transition of mild cognitive impairment to dementia","volume":"63","author":"Xu","year":"2009","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1530-0277.2008.00828.x","article-title":"Alcohol in moderation, cardioprotection, and neuroprotection: Epidemiological considerations and mechanistic studies","volume":"33","author":"Collins","year":"2009","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/13607863.2012.742488","article-title":"The impact of alcohol on Alzheimer\u2019s disease: A systematic review","volume":"17","author":"Gaffud","year":"2013","journal-title":"Aging Ment. Health"},{"key":"ref_50","first-page":"155","article-title":"Chronic diseases and conditions related to alcohol use","volume":"35","author":"Shield","year":"2014","journal-title":"Alcohol Res."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Anstey, K.J., and Peters, R. (2018). Alcohol and dementia: Risk or protective factor?. Nat. Rev. Neurol.","DOI":"10.1038\/s41582-018-0073-0"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/JGP.0b013e3181a2fd07","article-title":"Alcohol consumption as a risk factor for dementia and cognitive decline: Meta-analysis of prospective studies","volume":"17","author":"Anstey","year":"2009","journal-title":"Am. J. Geriatr. Psychiatry."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.15288\/jsa.2004.65.115","article-title":"College student protective strategies and drinking consequences","volume":"65","author":"Benton","year":"2004","journal-title":"J. Stud. Alcohol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2147\/NDT.S23159","article-title":"Moderate alcohol consumption and cognitive risk","volume":"7","author":"Neafsey","year":"2011","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/j.1530-0277.2001.tb02185.x","article-title":"Dose-Related Impact of Alcohol Consumption on Cognitive Function in Advanced Age: Results of a Multicenter Survey","volume":"25","author":"Onder","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_56","first-page":"1040","article-title":"Alcohol abuse and Alzheimer\u2019s disease","volume":"45","author":"Larkin","year":"1994","journal-title":"Hosp. Community Psychiatry"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1532-5415.2004.52159.x","article-title":"Alcohol intake and risk of dementia","volume":"52","author":"Luchsinger","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/aje\/kwm366","article-title":"Alcoholic beverages and incidence of dementia: 34-year follow-up of the prospective population study of women in G\u00f6teborg","volume":"167","author":"Mehlig","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0140-6736(02)07493-7","article-title":"Alcohol consumption and risk of dementia: The Rotterdam Study","volume":"359","author":"Ruitenberg","year":"2002","journal-title":"Lancet"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0895-4356(02)00462-6","article-title":"Alcohol consumption and incidence of dementia in a community sample aged 75 years and older","volume":"55","author":"Huang","year":"2002","journal-title":"J. Clin. Epidemiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1212\/01.WNL.0000031421.50369.E7","article-title":"Amount and type of alcohol and risk of dementia: The Copenhagen City Heart Study","volume":"59","author":"Truelsen","year":"2002","journal-title":"Neurology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/ageing\/afr007","article-title":"Current alcohol consumption and its relationship to incident dementia: Results from a 3-year follow-up study among primary care attenders aged 75 years and older","volume":"40","author":"Weyerer","year":"2011","journal-title":"Age Ageing"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/bmj.38181.418958.BE","article-title":"Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: A prospective population based study","volume":"329","author":"Anttila","year":"2004","journal-title":"Br. Med. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/gps.2372","article-title":"The effect of alcohol and tobacco consumption, and apolipoprotein E genotype, on the age of onset in Alzheimer\u2019s disease","volume":"25","author":"Harwood","year":"2010","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1056\/NEJMoa041152","article-title":"Effects of moderate alcohol consumption on cognitive function in women","volume":"352","author":"Stampfer","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1007\/s11064-015-1581-6","article-title":"The Glymphatic System: A Beginner\u2019s Guide","volume":"40","author":"Jessen","year":"2015","journal-title":"Neurochem. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1038\/s41598-018-20424-y","article-title":"Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function","volume":"8","author":"Lundgaard","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.neuropharm.2011.08.030","article-title":"Ethanol protects cultured neurons against amyloid-\u03b2 and \u03b1-synuclein-induced synapse damage","volume":"61","author":"Bate","year":"2011","journal-title":"Neuropharmacology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2174\/1567205013666160603005035","article-title":"The association between alcohol use and the progression of Alzheimer\u2019s disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Curr. Alzheimer Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e1910319","DOI":"10.1001\/jamanetworkopen.2019.10319","article-title":"Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults with or Without Mild Cognitive Impairment","volume":"2","author":"Koch","year":"2019","journal-title":"JAMA Netw. Open."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2017.08.013","article-title":"Adolescent binge ethanol exposure alters specific forebrain cholinergic cell populations and leads to selective functional deficits in the prefrontal cortex","volume":"361","author":"Fernandez","year":"2017","journal-title":"Neuroscience"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1530-0277.1992.tb00702.x","article-title":"Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: A quantitative MRI study","volume":"16","author":"Pfefferbaum","year":"1992","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.coph.2004.06.011","article-title":"Ethanol and brain damage","volume":"5","author":"Harper","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"\u00d6kvist, A., Johansson, S., Kuzmin, A., Bazov, I., Merino-Martinez, R., Ponomarev, I., Mayfield, R.D., Adron Harris, R., Sheedy, D., and Garrick, T. (2007). Neuroadaptations in Human Chronic Alcoholics: Dysregulation of the NF-\u03baB System. PLoS ONE.","DOI":"10.1371\/journal.pone.0000930"},{"key":"ref_75","first-page":"173","article-title":"Impairment in memory function and neurodegenerative changes in the cholinergic basal forebrain system induced by chronic intake of ethanol","volume":"44","author":"Arendt","year":"1994","journal-title":"J. Neural. Transm."},{"key":"ref_76","first-page":"299","article-title":"Alcohol use and the risk of developing Alzheimer\u2019s disease","volume":"25","author":"Tyas","year":"2001","journal-title":"Alcohol. Res. Health"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0741-8329(92)90059-J","article-title":"Alzheimer\u2019s disease and alcoholism: Possible interactions","volume":"9","author":"Freund","year":"1992","journal-title":"Alcohol"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.nbd.2012.12.016","article-title":"Microglial activation is not equivalent to neuroinflammation in alcohol-induced neurodegeneration: The importance of microglia phenotype","volume":"54","author":"Marshall","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.4049\/jimmunol.175.10.6893","article-title":"Involvement of TLR4\/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes","volume":"175","author":"Blanco","year":"2005","journal-title":"J. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.0803590","article-title":"Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol","volume":"183","author":"Pascual","year":"2009","journal-title":"J. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1750-3639.2004.tb00079.x","article-title":"Chronic ethanol treatment enhances inflammatory mediators and cell death in the brain and in astrocytes","volume":"14","author":"Valles","year":"2004","journal-title":"Brain Pathol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1111\/j.1530-0277.2010.01271.x","article-title":"Role of microglia in ethanol\u2019s apoptotic action on hypothalamic neuronal cells in primary cultures","volume":"34","author":"Boyadjieva","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1530-0277.2012.01889.x","article-title":"Microglia play a role in ethanol-induced oxidative stress and apoptosis in developing hypothalamic neurons","volume":"37","author":"Boyadjieva","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11011-014-9531-6","article-title":"The role of the microglia in acute CNS injury","volume":"30","author":"Kawabori","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00001756-200403220-00021","article-title":"Ethanol-induced iNOS and COX-2 expression in cultured astrocytes via NF-kappa B","volume":"15","author":"Blanco","year":"2004","journal-title":"Neuroreport"},{"key":"ref_86","first-page":"331","article-title":"Neuroimmune Function and the Consequences of Alcohol Exposure","volume":"37","author":"Crews","year":"2015","journal-title":"Alcohol. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.neuropharm.2017.01.031","article-title":"The role of neuroimmune signaling in alcoholism","volume":"122","author":"Crews","year":"2017","journal-title":"Neuropharmacology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brainres.2016.05.027","article-title":"Sustained alterations in neuroimmune gene expression after daily, but not intermittent, alcohol exposure","volume":"1646","author":"Gano","year":"2016","journal-title":"Brain Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3389\/fimmu.2018.01107","article-title":"Lifelong Impacts of Moderate Prenatal Alcohol Exposure on Neuroimmune Function","volume":"9","author":"Noor","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1037\/1064-1297.10.3.193","article-title":"Neurocognitive impairment associated with alcohol use disorders: Implications for treatment","volume":"10","author":"Bates","year":"2002","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnmol.2016.00008","article-title":"Alcohol, Excitotoxicity and Adult Brain Damage: An Experimentally Unproven Chain-of-Events","volume":"9","author":"Collins","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Salas-Gomez, D., Fernandez-Gorgojo, M., Pozueta, A., Diaz-Ceballos, I., Lamarain, M., Perez, C., and Sanchez-Juan, P. (2016). Binge Drinking in Young University Students Is Associated with Alterations in Executive Functions Related to Their Starting Age. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166834"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1530-0277.2000.tb04586.x","article-title":"Neurocognitive functioning of adolescents: Effects of protracted alcohol use. Alcohol","volume":"24","author":"Brown","year":"2000","journal-title":"Clin. Exp. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/0-306-48626-1_8","article-title":"Age-related effects of alcohol on memory and memory-related brain function in adolescents and adults","volume":"17","author":"White","year":"2005","journal-title":"Recent Dev. Alcohol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1460-9568.2006.05298.x","article-title":"Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats","volume":"25","author":"Pascual","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/01.ALC.0000113416.65546.01","article-title":"Alcohol-induced neurodegeneration: When, where and why?","volume":"28","author":"Crews","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/0361-9230(88)90193-1","article-title":"Loss of neurons in the rat basal forebrain cholinergic projection system after prolonged intake of ethanol","volume":"21","author":"Arendt","year":"1988","journal-title":"Brain Res. Bull."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.neuro.2019.10.005","article-title":"Effects of chronic alcohol consumption and withdrawal on the cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei of the rat: An unbiased stereological study","volume":"7","author":"Pereira","year":"2020","journal-title":"Neurotoxicology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archneur.62.3.425","article-title":"Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer\u2019s disease","volume":"62","author":"Ikonomovic","year":"2005","journal-title":"Arch. Neurol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Di Bari, M., Reale, M., Di Nicola, M., Orlando, V., Galizia, S., Porfilio, I., Costantini, E., D\u2019Angelo, C., Ruggieri, S., and Biagioni, S. (2016). Dysregulated Homeostasis of Acetylcholine Levels in Immune Cells of RR-Multiple Sclerosis Patients. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122009"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/acer.13919","article-title":"The Toll-Like Receptor 3 Agonist Poly (I:C) Induces Rapid and Lasting Changes in Gene Expression Related to Glutamatergic Function and Increases Ethanol Self-Administration in Rats","volume":"43","author":"Randall","year":"2019","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1742-2094-5-10","article-title":"Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment","volume":"5","author":"Qin","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.bbadis.2015.01.014","article-title":"The pharmacology of resveratrol in animals and humans","volume":"1852","author":"Park","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.bbadis.2014.10.006","article-title":"Roles of resveratrol and other grape-derived polyphenols in Alzheimer\u2019s disease prevention and treatment","volume":"1852","author":"Pasinetti","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1523\/JNEUROSCI.1521-05.2005","article-title":"Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice","volume":"25","author":"Shytle","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2015.01.027","article-title":"The flavonoid quercetin ameliorates Alzheimer\u2019s disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer\u2019s disease model mice","volume":"93","author":"Osorio","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3233\/JAD-2009-0916","article-title":"Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer\u2019s disease-type neuropathology and cognitive deterioration","volume":"16","author":"Ho","year":"2009","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_108","first-page":"97","article-title":"Role of grape seed polyphenols in Alzheimer\u2019s disease neuropathology","volume":"2","author":"Pasinetti","year":"2010","journal-title":"Nutr. Diet."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1523\/JNEUROSCI.0364-08.2008","article-title":"Grape-derived polyphenolics prevent A\u03b2 oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer\u2019s disease","volume":"28","author":"Wang","year":"2008","journal-title":"J. Neurosci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"914273","DOI":"10.1155\/2012\/914273","article-title":"Dietary polyphenols as modulators of brain functions: Biological actions and molecular mechanisms underpinning their beneficial effects","volume":"2012","author":"Vauzour","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.4161\/cc.7.8.5740","article-title":"Resveratrol: A multitargeted agent for age-associated chronic diseases","volume":"7","author":"Harikumar","year":"2008","journal-title":"Cell Cycle"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3177\/jnsv.46.78","article-title":"Resveratrol attenuates ovariectomy-induced hypertension and bone loss in stroke-prone spontaneously hypertensive rats","volume":"46","author":"Mizutani","year":"2000","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2008.02.018","article-title":"Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons","volume":"1204","author":"Antonio","year":"2008","journal-title":"Brain Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cell.2010.06.020","article-title":"SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM","volume":"142","author":"Donmez","year":"2010","journal-title":"Cell"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.bmc.2006.09.069","article-title":"Inhibitory activity of stilbenes on Alzheimer\u2019s \u03b2-amyloid fibrils in vitro","volume":"15","author":"Riviere","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"37377","DOI":"10.1074\/jbc.M508246200","article-title":"Resveratrol promotes clearance of Alzheimer\u2019s disease amyloid-\u03b2 peptides","volume":"280","author":"Marambaud","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/cmdc.201100585","article-title":"Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: Strategies and mechanisms","volume":"7","author":"Liu","year":"2012","journal-title":"Chem. Med. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e1576","DOI":"10.1038\/cddis.2014.530","article-title":"Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells","volume":"5","author":"Zhou","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/jf020864z","article-title":"Sequestering ability of butylated hydroxytoluene, propyl gallate, resveratrol, and vitamins C and E against ABTS, DPPH, and hydroxyl free radicals in chemical and biological systems","volume":"51","author":"Soares","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2478\/acb-2014-0006","article-title":"Antioxidant properties of resveratrol and its protective effects in neurodegenerative diseases","volume":"4","author":"Gerszon","year":"2014","journal-title":"Adv. Cell Biol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"36662","DOI":"10.1074\/jbc.M113.466490","article-title":"Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells","volume":"288","author":"Gueguen","year":"2013","journal-title":"J. Biol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tips.2012.05.007","article-title":"The neurobiology of sirtuins and their role in neurodegeneration","volume":"33","author":"Donmez","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fncel.2012.00063","article-title":"SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells","volume":"6","author":"Khan","year":"2012","journal-title":"Front. Cell. Neurosci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/sj.emboj.7601758","article-title":"SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer\u2019s disease and amyotrophic lateral sclerosis","volume":"26","author":"Kim","year":"2007","journal-title":"EMBO J."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","article-title":"Resveratrol mitigates lipopolysaccharide-and A\u03b2-mediated microglial inflammation by inhibiting the TLR4\/NF-\u03baB\/STAT signaling cascade","volume":"120","author":"Capiralla","year":"2012","journal-title":"J. Neurochem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.4161\/auto.26336","article-title":"Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway","volume":"9","author":"Chen","year":"2013","journal-title":"Autophagy"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"22727","DOI":"10.1074\/jbc.M314302200","article-title":"Resveratrol is a peroxidase-mediated inactivator of COX-1 but not cox-2 a mechanistic approach to the design of cox-1 selective agents","volume":"279","author":"Szewczuk","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/MCO.0b013e3282f0cef2","article-title":"Polyphenols and inflammation: Basic interactions","volume":"10","author":"Biesalski","year":"2007","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nature06261","article-title":"Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes","volume":"450","author":"Milne","year":"2007","journal-title":"Nature"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1042\/BST0351156","article-title":"Resveratrol as an antioxidant and pro-oxidant agent: Mechanisms and clinical implications","volume":"35","author":"Villegas","year":"2007","journal-title":"Biochem. Soc. Trans."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/biof.5520270121","article-title":"Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials","volume":"27","author":"Aruoma","year":"2006","journal-title":"Biofactors"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Park, J.Y., Kim, Y., Im, J.A., and Lee, H. (2015). Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model. BMC Complementary Altern. Med., 15.","DOI":"10.1186\/s12906-015-0709-1"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jnutbio.2018.02.001","article-title":"Beneficial effects of white wine polyphenols-enriched diet on Alzheimer\u2019s disease-like pathology","volume":"55","author":"Mendes","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jyp.2013.11.005","article-title":"In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer\u2019s disease","volume":"5","author":"Islam","year":"2013","journal-title":"J. Young Pharm."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1096\/fj.12-212118","article-title":"Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer\u2019s disease","volume":"27","author":"Ho","year":"2013","journal-title":"FASEB J."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1471-4159.2003.01976.x","article-title":"Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer\u2019s disease","volume":"87","author":"Ono","year":"2003","journal-title":"J. Neurochem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1177\/0748233713504810","article-title":"Neuroprotective effect of quercetin against oxidative damage and neuronal apoptosis caused by cadmium in hippocampus","volume":"32","author":"Kanter","year":"2016","journal-title":"Toxicol. Ind. Health"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1021\/jf303387d","article-title":"Quercetin protects mouse brain against lead-induced neurotoxicity","volume":"61","author":"Liu","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2986796","DOI":"10.1155\/2016\/2986796","article-title":"Mechanisms of neuroprotection by quercetin: Counteracting oxidative stress and more","volume":"2016","author":"Costa","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejphar.2006.11.014","article-title":"The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells","volume":"557","author":"Crespo","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.neurobiolaging.2015.05.006","article-title":"Quercetin reduces eIF2\u03b1 phosphorylation by GADD34 induction","volume":"36","author":"Hayakawa","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2012.02.029","article-title":"Potential protection of green tea polyphenols against intracellular amyloid beta-induced toxicity on primary cultured prefrontal cortical neurons of rats","volume":"513","author":"Qin","year":"2012","journal-title":"Neurosci. Lett."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.abb.2010.05.002","article-title":"Suppression mechanisms of flavonoids on aryl hydrocarbon receptor-mediated signal transduction","volume":"501","author":"Mukai","year":"2010","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1016\/j.febslet.2011.06.030","article-title":"Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation","volume":"585","author":"Ferreira","year":"2011","journal-title":"FEBS Lett."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0024-3205(01)01438-2","article-title":"The green tea polyphenol (\u2212)-epigallocatechin gallate attenuates \u03b2-amyloid-induced neurotoxicity in cultured hippocampal neurons","volume":"70","author":"Choi","year":"2001","journal-title":"Life Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12937-016-0179-4","article-title":"Potential neuroprotective properties of epigallocatechin-3-gallate (EGCG)","volume":"15","author":"Singh","year":"2015","journal-title":"Nutr. J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.febslet.2014.11.026","article-title":"The green tea polyphenol(\u2212)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios","volume":"589","author":"Wobst","year":"2015","journal-title":"FEBS Lett."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4162\/nrp.2015.9.2.123","article-title":"Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell","volume":"9","author":"Ahn","year":"2015","journal-title":"Nutr. Res. 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