{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:24:33Z","timestamp":1775028273990,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003450","name":"Griffith Health Institute, Griffith University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100003450","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Selenium is an essential micronutrient commonly deficient in human populations. Selenium deficiency increases the risks of pregnancy complications; however, the long-term impact of selenium deficiency on offspring disease remains unclear. This study investigates the effects of selenium deficiency during pregnancy on offspring metabolic function. Female C57BL\/6 mice were allocated to control (&gt;190 \u03bcg selenium\/kg, n = 8) or low selenium (&lt;50 \u03bcg selenium\/kg, n = 8) diets prior to mating and throughout gestation. At postnatal day (PN) 170, mice underwent an intraperitoneal glucose tolerance test and were culled at PN180 for biochemical analysis. Mice exposed to selenium deficiency in utero had reduced fasting blood glucose but increased postprandial blood glucose concentrations. Male offspring from selenium-deficient litters had increased plasma insulin levels in conjunction with reduced plasma thyroxine (tetraiodothyronine or T4) concentrations. Conversely, females exposed to selenium deficiency in utero exhibited increased plasma thyroxine levels with no change in plasma insulin. This study demonstrates the importance of adequate selenium intake around pregnancy for offspring metabolic health. Given the increasing prevalence of metabolic disease, this study highlights the need for appropriate micronutrient intake during pregnancy to ensure a healthy start to life.<\/jats:p>","DOI":"10.3390\/nu12010267","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T03:04:43Z","timestamp":1579575883000},"page":"267","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Maternal Selenium Deficiency in Mice Alters Offspring Glucose Metabolism and Thyroid Status in a Sexually Dimorphic Manner"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4716-4016","authenticated-orcid":false,"given":"Pierre","family":"Hofstee","sequence":"first","affiliation":[{"name":"School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold, Coast Campus, Southport, QLD 4215, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel R.","family":"McKeating","sequence":"additional","affiliation":[{"name":"School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold, Coast Campus, Southport, QLD 4215, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy A.","family":"Bartho","sequence":"additional","affiliation":[{"name":"School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold, Coast Campus, Southport, QLD 4215, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T.","family":"Anderson","sequence":"additional","affiliation":[{"name":"The School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-6772","authenticated-orcid":false,"given":"Anthony V.","family":"Perkins","sequence":"additional","affiliation":[{"name":"School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold, Coast Campus, Southport, QLD 4215, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James S. M.","family":"Cuffe","sequence":"additional","affiliation":[{"name":"School of Medical Science, Menzies Health Institute Queensland, Griffith University Gold, Coast Campus, Southport, QLD 4215, Australia"},{"name":"The School of Biomedical Sciences, The University of Queensland, St Lucia, QLD 4072, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hsu, C.-N., and Tain, Y.-L. (2019). The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental Programming of Adult Disease. Nutrients, 11.","DOI":"10.3390\/nu11040894"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/1440-1681.12954","article-title":"Placental adaptations to micronutrient dysregulation in the programming of chronic disease","volume":"45","author":"Hofstee","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jtemb.2014.07.003","article-title":"The role of selenium in human conception and pregnancy","volume":"29","author":"Grajeta","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1503\/cmaj.101095","article-title":"Maternal selenium status during early gestation and risk for preterm birth","volume":"183","author":"Rayman","year":"2011","journal-title":"CMAJ"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lewandowska, M., Sajdak, S., and Lubinski, J. (2019). Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension. Nutrients, 11.","DOI":"10.3390\/nu11051028"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1017\/S000711451400364X","article-title":"Selenium status in UK pregnant women and its relationship with hypertensive conditions of pregnancy","volume":"113","author":"Rayman","year":"2015","journal-title":"Br. J. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12937-016-0211-8","article-title":"Serum selenium level and gestational diabetes mellitus: a systematic review and meta-analysis","volume":"15","author":"Kong","year":"2016","journal-title":"Nutr. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lewandowska, M., Sajdak, S., and Lubinski, J. (2019). The Role of Early Pregnancy Maternal Selenium Levels on the Risk for Small-for-Gestational Age Newborns. Nutrients, 11.","DOI":"10.3390\/nu11102298"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/AOG.0b013e3181f3a1f9","article-title":"Maternal pregnancy-related hypertension and risk for hypertension in offspring later in life","volume":"116","author":"Palmsten","year":"2010","journal-title":"Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3109\/14767058.2013.853733","article-title":"Gestational diabetes mellitus, programing and epigenetics","volume":"27","author":"Yan","year":"2014","journal-title":"J. Matern.-Fetal Neonatal Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.nutres.2006.08.008","article-title":"Low-normal serum selenium early in human pregnancy predicts lower birth weight","volume":"26","author":"Bogden","year":"2006","journal-title":"Nutr. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1039\/C6FO00595K","article-title":"Metabolic syndrome and selenium in fetal programming: gender differences","volume":"7","author":"Ojeda","year":"2016","journal-title":"Food Funct."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00018-005-5313-y","article-title":"Understanding the importance of selenium and selenoproteins in muscle function","volume":"63","author":"Rederstorff","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_15","first-page":"89","article-title":"Skeletal muscle fiber types in C57BL6J mice","volume":"21","author":"Augusto","year":"2004","journal-title":"Braz. J. Morphol. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1089\/thy.2005.15.841","article-title":"Selenium and the control of thyroid hormone metabolism","volume":"15","year":"2005","journal-title":"Thyroid"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/BF03347465","article-title":"Physiological role and regulation of iodothyronine deiodinases: A 2011 update","volume":"34","author":"Marsili","year":"2011","journal-title":"J. Endocrinol. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1113\/JP278473","article-title":"Maternal selenium deficiency during pregnancy in mice increases thyroid hormone concentrations, alters placental function and reduces fetal growth","volume":"597","author":"Hofstee","year":"2019","journal-title":"J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00404-018-5018-8","article-title":"Thyroid function and thyroid disorders during pregnancy: A review and care pathway","volume":"299","author":"Delitala","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1113\/JP277815","article-title":"Maternal corticosterone in the mouse alters oxidative stress markers, antioxidant function and mitochondrial content in placentas of female fetuses","volume":"597","author":"Bartho","year":"2019","journal-title":"J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.placenta.2016.12.022","article-title":"Effects of maternal micronutrient supplementation on placental function","volume":"54","author":"Richard","year":"2017","journal-title":"Placenta"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Pappas, A.C., Zoidis, E., and Chadio, S.E. (2019). Maternal Selenium and Developmental Programming. Antioxidants, 8.","DOI":"10.3390\/antiox8050145"},{"key":"ref_23","first-page":"321","article-title":"Placental-fetal glucose exchange and fetal glucose metabolism","volume":"117","author":"Hay","year":"2006","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1210\/jc.2018-01154","article-title":"Uteroplacental glucose uptake and fetal glucose consumption: A quantitative study in human pregnancies","volume":"104","author":"Michelsen","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-0031-1275516","article-title":"The intrauterine growth restriction phenotype: Fetal adaptations and potential implications for later life insulin resistance and diabetes","volume":"29","author":"Thorn","year":"2011","journal-title":"Semin. Reprod. Med."},{"key":"ref_26","first-page":"476279","article-title":"Pathogenesis of insulin resistance in skeletal muscle","volume":"2010","author":"DeFronzo","year":"2010","journal-title":"BioMed Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0140-6736(97)07244-9","article-title":"Glucose tolerance in adults after prenatal exposure to famine","volume":"351","author":"Ravelli","year":"1998","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S157","DOI":"10.2337\/dc09-S302","article-title":"Skeletal muscle insulin resistance is the primary defect in type 2 diabetes","volume":"32","author":"DeFronzo","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"E1128","DOI":"10.1152\/ajpendo.1996.271.6.E1128","article-title":"Altered muscle insulin sensitivity in the male offspring of protein-malnourished rats","volume":"271","author":"Ozanne","year":"1996","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00109-012-0896-x","article-title":"Selenoprotein N in skeletal muscle: from diseases to function","volume":"90","author":"Castets","year":"2012","journal-title":"J. Mol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ana.20761","article-title":"SEPN1: Associated with congenital fiber-type disproportion and insulin resistance","volume":"59","author":"Clarke","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11154-007-9050-4","article-title":"Metabolic programming in the pathogenesis of insulin resistance","volume":"8","author":"Devaskar","year":"2007","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1152\/advan.00080.2014","article-title":"Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle","volume":"38","author":"Stanford","year":"2014","journal-title":"Adv. Physiol. Educ."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-11-0489","article-title":"Sex differences in developmental programming models","volume":"145","author":"Aiken","year":"2013","journal-title":"Reproduction"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2337\/diabetes.52.7.1749","article-title":"Estrogen blunts neuroendocrine and metabolic responses to hypoglycemia","volume":"52","author":"Sandoval","year":"2003","journal-title":"Diabetes"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cbpc.2008.10.106","article-title":"Corticosterone suppresses insulin-and NO-stimulated muscle glucose uptake in broiler chickens (Gallus gallus domesticus)","volume":"149","author":"Zhao","year":"2009","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1297658","DOI":"10.1155\/2017\/1297658","article-title":"Selenium and thyroid disease: From pathophysiology to treatment","volume":"2017","author":"Ventura","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S2213-8587(15)00327-7","article-title":"Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: A population-based prospective cohort study","volume":"4","author":"Korevaar","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1210\/en.2007-0677","article-title":"Effects of maternal levels of thyroid hormone (TH) on the hypothalamus-pituitary-thyroid set point: studies in TH receptor \u03b2 knockout mice","volume":"148","author":"Alonso","year":"2007","journal-title":"Endocrinology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1210\/jc.2006-0841","article-title":"Thyroid function is intrinsically linked to insulin sensitivity and endothelium-dependent vasodilation in healthy euthyroid subjects","volume":"91","author":"Castro","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","first-page":"147","article-title":"Study of insulin resistance in subclinical hypothyroidism","volume":"4","author":"Vyakaranam","year":"2014","journal-title":"Int. J. Health Sci. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1055\/s-2001-18584","article-title":"Thyroid hormone excess and glucose intolerance","volume":"109","author":"Dimitriadis","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1530\/eje.0.1430639","article-title":"Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT)","volume":"143","author":"Bjoro","year":"2000","journal-title":"Eur. J. Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/bdi.12150","article-title":"Gender differences in thyroid system function: relevance to bipolar disorder and its treatment","volume":"16","author":"Bauer","year":"2014","journal-title":"Bipolar Disord."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3389\/fendo.2019.00445","article-title":"Sex Dimorphic Responses of the Hypothalamus-Pituitary-Thyroid Axis to Maternal Separation and Palatable Diet","volume":"10","author":"Jaimes","year":"2019","journal-title":"Frontiers in endocrinol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1089\/met.2006.4.84","article-title":"Effects of diet and exercise on insulin resistance during pregnancy","volume":"4","author":"Clapp","year":"2006","journal-title":"Metab. Syndr. Relat. Disord."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2000-8847","article-title":"Exercise and insulin sensitivity: a review","volume":"21","author":"Borghouts","year":"2000","journal-title":"Int. J. Sports Med."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/1\/267\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:29:53Z","timestamp":1760362193000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/1\/267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["nu12010267"],"URL":"https:\/\/doi.org\/10.3390\/nu12010267","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]}}}