{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T09:04:30Z","timestamp":1772183070500,"version":"3.50.1"},"reference-count":66,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Altered martial indices before orthopedic surgery are associated with higher rates of complications and greatly affect the patient\u2019s functional ability. Oral supplements can optimize the preoperative martial status, with clinical efficacy and the patient\u2019s tolerability being highly dependent on the pharmaceutical formula. Patients undergoing elective hip\/knee arthroplasty were randomized to be supplemented with a 30-day oral therapy of sucrosomial ferric pyrophosphate plus L-ascorbic acid. The tolerability was 2.7% among treated patients. Adjustments for confounding factors, such as iron absorption influencers, showed a relevant response limited to older patients (\u2265 65 years old), whose uncharacterized Hb loss was averted upon treatment with iron formula. Older patients with no support lost \u22122.8 \u00b1 5.1%, while the intervention group gained +0.7 \u00b1 4.6% of circulating hemoglobin from baseline (p = 0.019). Gastrointestinal diseases, medications, and possible dietary factors could affect the efficacy of iron supplements. Future opportunities may consider to couple ferric pyrophosphate with other nutrients, to pay attention in avoiding absorption disruptors, or to implement interventions to obtain an earlier martial status optimization at the population level.<\/jats:p>","DOI":"10.3390\/nu12020386","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T11:55:56Z","timestamp":1580471756000},"page":"386","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Oral Supplementation with Sucrosomial Ferric Pyrophosphate Plus L-Ascorbic Acid to Ameliorate the Martial Status: A Randomized Controlled Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0801-2359","authenticated-orcid":false,"given":"Matteo","family":"Briguglio","sequence":"first","affiliation":[{"name":"Scientific Direction, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7857-4512","authenticated-orcid":false,"given":"Silvana","family":"Hrelia","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-7772","authenticated-orcid":false,"given":"Marco","family":"Malaguti","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"De Vecchi","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8365-985X","authenticated-orcid":false,"given":"Giovanni","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"},{"name":"Department of Athletics, Strength and Conditioning, Pozna\u0144 University of Physical Education, Kr\u00f3lowej Jadwigi 27\/39, 61-871 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Banfi","sequence":"additional","affiliation":[{"name":"Scientific Direction, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"},{"name":"Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Via Olgettina 58, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9204-7257","authenticated-orcid":false,"given":"Patrizia","family":"Riso","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition, Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2693-3311","authenticated-orcid":false,"given":"Marisa","family":"Porrini","sequence":"additional","affiliation":[{"name":"Division of Human Nutrition, Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Via Mangiagalli 25, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Joint Replacement Department, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pino","sequence":"additional","affiliation":[{"name":"Post-operative Intensive Care Unit &amp; Anesthesia, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziano","family":"Crespi","sequence":"additional","affiliation":[{"name":"Post-operative Intensive Care Unit &amp; Anesthesia, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Perazzo","sequence":"additional","affiliation":[{"name":"Post-operative Intensive Care Unit &amp; Anesthesia, IRCCS Orthopedic Institute Galeazzi, Via Riccardo Galeazzi 4, 20161 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,31]]},"reference":[{"key":"ref_1","unstructured":"World Health Organisation (WHO) (2011). 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