{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:11:12Z","timestamp":1773947472837,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T00:00:00Z","timestamp":1581552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1A2B6006175"],"award-info":[{"award-number":["NRF-2018R1A2B6006175"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016R1A6A1A03011325"],"award-info":[{"award-number":["NRF-2016R1A6A1A03011325"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>\u03b2-hydroxybutyrate (\u03b2-OHB) has been shown to exert an anti-inflammatory activity. Apolipoprotein-E (ApoE) is strongly associated with atherosclerosis and Alzheimer\u2019s disease (AD). This study aimed to explore the therapeutic effect of \u03b2-OHB in the brain and the aorta of high-fat diet (HFD)-fed ApoE-deficient mice. We found in Apo-E deficient mice that \u03b2-OHB attenuated lipid deposition in the choroid plexus (ChP) and decreased amyloid plaque in the substantia nigra pars compacta. We also found decreased CD68-positive macroglia infiltration of the ChP in \u03b2-OHB-treated ApoE-deficient mice. \u03b2-OHB treatment ameliorated IgG extravasation into the hippocampal region of the brain. In vitro study using ChP mice cell line revealed that \u03b2-OHB attenuated oxidized low-density lipoprotein-induced ApoE-specific differentially expressed inflammatory ChP genes. Treatment with \u03b2-OHB reduced aortic plaque formation without affecting blood lipid profiles and decreased serum production of resistin, a well-established risk factor for both AD and atherosclerosis. Thus, the current study suggests and describes the therapeutic potential of \u03b2-OHB for the treatment of AD and atherosclerosis.<\/jats:p>","DOI":"10.3390\/nu12020471","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T10:09:57Z","timestamp":1581674997000},"page":"471","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["\u03b2-hydroxybutyrate Impedes the Progression of Alzheimer\u2019s Disease and Atherosclerosis in ApoE-Deficient Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Manigandan","family":"Krishnan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Su","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hae","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9213-4748","authenticated-orcid":false,"given":"Jeeyoun","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunyoung","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Keimyung University, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,13]]},"reference":[{"key":"ref_1","first-page":"2589276","article-title":"Therapies for Prevention and Treatment of Alzheimer\u2019s Disease","volume":"2016","author":"Berumen","year":"2016","journal-title":"Biomed. 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