{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T07:56:00Z","timestamp":1789286160460,"version":"build-2803163510"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The prevalence of obesity in asthmatic children is high and is associated with worse clinical outcomes. We have previously reported that weight loss leads to improvements in lung function and asthma control in obese asthmatic children. The objectives of this secondary analysis were to examine: (1) changes in diet quality and (2) associations between the baseline subject characteristics and the degree of weight loss following the intervention. Twenty-eight obese asthmatic children, aged 8\u201317 years, completed a 10-week diet-induced weight loss intervention. Dietary intake, nutritional biomarkers, anthropometry, lung function, asthma control, and clinical outcomes were analysed before and after the intervention. Following the intervention, the body mass index (BMI) z-score decreased (\u0394 = 0.18 \u00b1 0.04; p &lt; 0.001), %energy from protein increased (\u0394 = 4.3 \u00b1 0.9%; p = 0.002), and sugar intake decreased (\u0394 = 23.2 \u00b1 9.3 g; p= 0.025). Baseline lung function and physical activity level were inversely associated with \u0394% fat mass. The \u0394BMI z-score was negatively associated with physical activity duration at baseline. Dietary intervention is effective in achieving acute weight loss in obese asthmatic children, with significant improvements in diet quality and body composition. Lower lung function and physical engagement at baseline were associated with lesser weight loss, highlighting that subjects with these attributes may require greater support to achieve weight loss goals.<\/jats:p>","DOI":"10.3390\/nu12020507","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T04:06:01Z","timestamp":1582085161000},"page":"507","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterising a Weight Loss Intervention in Obese Asthmatic Children"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1786-0141","authenticated-orcid":false,"given":"Shaun","family":"Eslick","sequence":"first","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8653-4801","authenticated-orcid":false,"given":"Megan E.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Priority Research Centre Grow Up Well, Hunter Medical Research Institute, School of Medicine and Public Health, The University of Newcastle, New Lambton Heights, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-756X","authenticated-orcid":false,"given":"Clare E.","family":"Collins","sequence":"additional","affiliation":[{"name":"Priority Research Centre in Physical Activity and Nutrition, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Hilton","sequence":"additional","affiliation":[{"name":"Pediatric Respiratory and Sleep Medicine, John Hunter Children\u2019s Hospital, New Lambton Heights, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0941-9225","authenticated-orcid":false,"given":"Lisa G.","family":"Wood","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"ref_1","first-page":"1000232","article-title":"Weight Management Interventions in Adult and Pediatric Asthma Populations: A Systematic Review","volume":"5","author":"Lv","year":"2015","journal-title":"J. Pulm. Respir. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1089\/ped.2011.0137","article-title":"Obesity, Nutrition, and Asthma in Children","volume":"25","author":"Lang","year":"2012","journal-title":"Pediatri. Allergy Immunol. Pulmonol."},{"key":"ref_3","unstructured":"Marks, G., Reddel, H., Copper, S., Poulos, L., Ampon, R., and Waters, A.M. (2011). Asthma in Australia 2011: with a focus chapter on chronic obstructive pulmonary disease."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980\u20132013: A systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"key":"ref_5","unstructured":"(2017). A picture of overweight and obesity in Australia 2017, Australian Institute of Health and Welfare."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"458","DOI":"10.5694\/j.1326-5377.2007.tb00997.x","article-title":"Overweight and obesity from childhood to adulthood: A follow-up of participants in the 1985 Australian Schools Health and Fitness Survey","volume":"186","author":"Venn","year":"2007","journal-title":"Med. J. Aust."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/rccm.200711-1754OC","article-title":"Cluster analysis and clinical asthma phenotypes","volume":"178","author":"Haldar","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1183\/09031936.00139810","article-title":"Airway inflammation is augmented by obesity and fatty acids in asthma","volume":"38","author":"Scott","year":"2011","journal-title":"Eur. Respir. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1152\/japplphysiol.00838.2009","article-title":"Obesity, adipokines, and lung disease","volume":"108","author":"Sood","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/nyas.12357","article-title":"Linking obesity and asthma","volume":"1311","author":"Sutherland","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jaci.2010.12.010","article-title":"Decreased response to inhaled steroids in overweight and obese asthmatic children","volume":"127","author":"Forno","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/adc.88.4.361","article-title":"The effects of obesity on pulmonary function","volume":"88","author":"Li","year":"2003","journal-title":"Arch. Dis. Child."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/cea.12115","article-title":"Diet-induced weight loss in obese children with asthma: A randomized controlled trial","volume":"43","author":"Jensen","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ppul.21502","article-title":"Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents","volume":"47","author":"Cheik","year":"2012","journal-title":"Pediatr. Pulmonol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/ppul.22932","article-title":"Effects of dietary induced weight loss on exercise-induced bronchoconstriction in overweight and obese children","volume":"49","author":"Hoogstrate","year":"2014","journal-title":"Pediatr. Pulmonol."},{"key":"ref_16","first-page":"682","article-title":"Impact of weight loss on markers of systemic inflammation in obese Saudi children with asthma","volume":"13","author":"Ashmawy","year":"2013","journal-title":"Afr. Health Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1183\/09031936.00103311","article-title":"Overweight is not a comorbidity factor during childhood asthma: The GrowthOb study","volume":"39","author":"Mahut","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_18","unstructured":"Global Initiative for Asthma (2005). Pocket Guide for Asthma Management and Prevention in Children, National Institute of Health. Contract No.:02-3659."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1034\/j.1399-3003.1999.14d29.x","article-title":"Development and validation of a questionnaire to measure asthma control","volume":"14","author":"Juniper","year":"1999","journal-title":"Eur. Respi. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3109\/02770900903533966","article-title":"Reliability, validity, and responsiveness of the Pediatric Quality of Life Inventory\u2122(PedsQL\u2122) Generic Core Scales and Asthma Symptoms Scale in vulnerable children with asthma","volume":"47","author":"Seid","year":"2010","journal-title":"J. Asthma"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm.159.1.9712108","article-title":"Spirometric reference values from a sample of the general US population","volume":"159","author":"Hankinson","year":"1999","journal-title":"Am. J. Respir. Crit. Care Medi."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4187\/respcare.01640","article-title":"Pulmonary function testing","volume":"57","author":"Ruppel","year":"2012","journal-title":"Respir. Care"},{"key":"ref_23","unstructured":"Division of Nutritional Physical Activity and Obesity (2017, November 22). National Center for Chronic Disease Prevention and Health Promotion. A SAS Program for the CDC Growth Charts; Center for Disease Control and Prevention, Available online: https:\/\/www.cdc.gov\/nccdphp\/dnpao\/growthcharts\/resources\/sas-who.htm."},{"key":"ref_24","unstructured":"Australian Government Department of Health and Ageing, and National Health and Medical Research Council (2006). Nutrient Reference Values for Australia and New Zealand: Including Recommended Dietary Intakes, National Health and Medical Research Council. Version 1.2."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0378-4347(93)80496-Q","article-title":"New simplified procedures for the extraction and simultaneous high-performance liquid chromatographic analysis of retinol, tocopherols, and carotenoids in human serum","volume":"617","author":"Barua","year":"1993","journal-title":"J. Chromatogr. B"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1080\/07315724.2005.10719490","article-title":"Airway and circulating levels of carotenoids in asthma and healthy controls","volume":"24","author":"Wood","year":"2005","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/ajcn\/77.1.150","article-title":"Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function","volume":"77","author":"Wood","year":"2003","journal-title":"Am. Clin. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-2275(20)38861-1","article-title":"Direct transesterification of all classes of lipids in a one-step reaction","volume":"27","author":"Lepage","year":"1986","journal-title":"J. Lipid Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1542\/peds.2012-1176","article-title":"Effectiveness of lifestyle interventions in child obesity: Systematic review with meta-analysis","volume":"130","author":"Ho","year":"2012","journal-title":"Pediatrics"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/sj.ijo.0803509","article-title":"Outcome data from the LEAP (Live, Eat and Play) trial: A randomized controlled trial of a primary care intervention for childhood overweight\/mild obesity","volume":"31","author":"McCallum","year":"2007","journal-title":"Int. J. Obes."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clnu.2009.12.010","article-title":"An effective lifestyle intervention in overweight children: Findings from a randomized controlled trial on \u201cObeldicks light\u201d","volume":"29","author":"Reinehr","year":"2010","journal-title":"Clin. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1249\/MSS.0b013e31819b6aea","article-title":"Aerobic and Strength Training Reduces Adiposity in Overweight Latina Adolescents","volume":"41","author":"Davis","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/met.2006.0038","article-title":"Reduction in Added Sugar Intake and Improvement in Insulin Secretion in Overweight Latina Adolescents","volume":"5","author":"Davis","year":"2007","journal-title":"Metab. Syndr. Relat. D."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.2196\/mhealth.3324","article-title":"A Mobile Phone Food Record App to Digitally Capture Dietary Intake for Adolescents in a Free-Living Environment: Usability Study","volume":"3","author":"Casperson","year":"2015","journal-title":"JMIR MHealth UHealth"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.2196\/jmir.1967","article-title":"Novel Technologies for Assessing Dietary Intake: Evaluating the Usability of a Mobile Telephone Food Record Among Adults and Adolescents","volume":"14","author":"Daugherty","year":"2012","journal-title":"J. Med. Internet Res."},{"key":"ref_36","unstructured":"Australian Bureau of Statistics and Food Standards Australia and New Zealand (2015). 4364.0.55.008\u2014Australian Health Survey: Usual Nutrient Intakes, 2011\u20132012, Australian Bureau of Statistics."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.2047-6310.2011.00005.x","article-title":"Efficacy of U.S. Pediatric Obesity Primary Care Guidelines: Two Randomized Trials","volume":"7","author":"Raynor","year":"2012","journal-title":"Pediatr. Obes."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/chi.2012.0045","article-title":"Improving healthy dietary behaviors, nutrition knowledge, and self-efficacy among underserved school children with parent and community involvement","volume":"8","author":"Wright","year":"2012","journal-title":"Child. Obes."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s11883-010-0131-6","article-title":"Saturated fatty acids and risk of coronary heart disease: Modulation by replacement nutrients","volume":"12","author":"Sun","year":"2010","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"i5796","DOI":"10.1136\/bmj.i5796","article-title":"Intake of individual saturated fatty acids and risk of coronary heart disease in US men and women: Two prospective longitudinal cohort studies","volume":"355","author":"Zong","year":"2016","journal-title":"BMJ"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1021\/jf061818s","article-title":"Bioaccessibility of carotenoids and vitamin E from their main dietary sources","volume":"54","author":"Reboul","year":"2006","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.pharmthera.2009.03.015","article-title":"Dietary factors lead to innate immune activation in asthma","volume":"123","author":"Wood","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1164\/rccm.2112074","article-title":"Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants","volume":"166","author":"Romieu","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/thx.2006.069419","article-title":"Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete","volume":"62","author":"Chatzi","year":"2007","journal-title":"Thorax."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/resp.12423","article-title":"Determinants of weight loss success utilizing a meal replacement plan and\/or exercise, in overweight and obese adults with asthma","volume":"20","author":"Scott","year":"2015","journal-title":"Respirology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1542\/peds.2006-1846","article-title":"Asthma as a barrier to children\u2019s physical activity: Implications for body mass index and mental health","volume":"118","author":"Glazebrook","year":"2006","journal-title":"Pediatrics"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e341","DOI":"10.1542\/peds.113.4.e341","article-title":"Physical activity in urban school-aged children with asthma","volume":"113","author":"Lang","year":"2004","journal-title":"Pediatrics"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/2\/507\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:58:32Z","timestamp":1760173112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/2\/507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":47,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2]]}},"alternative-id":["nu12020507"],"URL":"https:\/\/doi.org\/10.3390\/nu12020507","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]}}}