{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:10:29Z","timestamp":1785208229678,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["DEP2017-86409-C2-1-P"],"award-info":[{"award-number":["DEP2017-86409-C2-1-P"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["DEP2015-71171-R"],"award-info":[{"award-number":["DEP2015-71171-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite\u00ae, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 h thereafter for 24 h, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite\u00ae combined with 140 mg of quercetin (double-blind). Although competition times were similar, polyphenol supplementation attenuated the muscle pain felt after the competition (6.8 \u00b1 1.5 and 5.7 \u00b1 2.2 a.u., p = 0.035) and the loss of jumping performance (9.4 \u00b1 11.5 and 3.9 \u00b1 5.2%, p = 0.036; p = 0.034) and mechanical impulse (p = 0.038) 24 h later. The polyphenols attenuated the increase of serum myoglobin and alanine aminotransferase in men, but not in women (interaction p &lt; 0.05). In conclusion, a single dose of 140 mg Zynamite\u00ae combined with 140 mg of quercetin, administered one hour before competition, followed by three additional doses every eight hours, attenuates muscle pain and damage, and accelerates the recovery of muscle performance.<\/jats:p>","DOI":"10.3390\/nu12030614","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T03:21:16Z","timestamp":1582773676000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Supplementation with a Mango Leaf Extract (Zynamite\u00ae) in Combination with Quercetin Attenuates Muscle Damage and Pain and Accelerates Recovery after Strenuous Damaging Exercise"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-2331","authenticated-orcid":false,"given":"Marcos","family":"Martin-Rincon","sequence":"first","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8963-5568","authenticated-orcid":false,"given":"Miriam","family":"Gelabert-Rebato","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"},{"name":"Nektium Pharma, Ag\u00fcimes, 35118 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-3471","authenticated-orcid":false,"given":"Victor","family":"Galvan-Alvarez","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8068-9586","authenticated-orcid":false,"given":"Angel","family":"Gallego-Selles","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Martinez-Canton","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lopez-Rios","sequence":"additional","affiliation":[{"name":"Nektium Pharma, Ag\u00fcimes, 35118 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Nektium Pharma, Ag\u00fcimes, 35118 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saul","family":"Martin-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-1908","authenticated-orcid":false,"given":"Rafael","family":"Arteaga-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6616-6810","authenticated-orcid":false,"given":"Cecilia","family":"Dorado","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Perez-Regalado","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1075-9948","authenticated-orcid":false,"given":"Alfredo","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"},{"name":"Complejo Hospitalario Universitario Insular-Materno Infantil de Las Palmas de Gran Canaria, Clinical Genetics Unit, 35016 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-397X","authenticated-orcid":false,"given":"David","family":"Morales-Alamo","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-6234","authenticated-orcid":false,"given":"Jose A L","family":"Calbet","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Campus Universitario de Tafira s\/n, 35017 Las Palmas de Gran Canaria, Spain"},{"name":"Department of Physical Performance, Norwegian School of Sport Sciences, 0806 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1515\/CCLM.2010.179","article-title":"Biochemical markers of muscular damage","volume":"48","author":"Brancaccio","year":"2010","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/17461391.2018.1505957","article-title":"Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions?","volume":"19","author":"Owens","year":"2019","journal-title":"Eur. J. Sport Sci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2165\/00007256-199621030-00005","article-title":"The role of antioxidant vitamins and enzymes in the prevention of exercise-induced muscle damage","volume":"21","author":"Dekkers","year":"1996","journal-title":"Sports Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2165\/11594400-000000000-00000","article-title":"Antioxidant supplementation during exercise training: Beneficial or detrimental?","volume":"41","author":"Peternelj","year":"2011","journal-title":"Sports Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.2165\/11317890-000000000-00000","article-title":"Does antioxidant vitamin supplementation protect against muscle damage?","volume":"39","author":"McGinley","year":"2009","journal-title":"Sports Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s40279-018-0998-x","article-title":"Fruit-derived polyphenol supplementation for athlete recovery and performance","volume":"49","author":"Bowtell","year":"2019","journal-title":"Sports Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10787-018-0507-8","article-title":"Pharmacological and biochemical studies on protective effects of mangiferin and its interaction with nitric oxide (no) modulators in adjuvant-induced changes in arthritic parameters, inflammatory, and oxidative biomarkers in rats","volume":"27","author":"Pal","year":"2019","journal-title":"Inflammopharmacology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1039\/C9FO00153K","article-title":"Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s10571-014-0039-8","article-title":"Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury","volume":"34","author":"Fu","year":"2014","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/ejcn.2017.55","article-title":"Effects of supplementation with quercetin on plasma c-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials","volume":"71","author":"Mazloom","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bazzucchi, I., Patrizio, F., Ceci, R., Duranti, G., Sgro, P., Sabatini, S., Di Luigi, L., Sacchetti, M., and Felici, F. (2019). The effects of quercetin supplementation on eccentric exercise-induced muscle damage. Nutrients, 11.","DOI":"10.3390\/nu11010205"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/sms.12136","article-title":"Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training","volume":"24","author":"Casuso","year":"2014","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2165\/00007256-200434010-00005","article-title":"Neuromuscular function after exercise-induced muscle damage: Theoretical and applied implications","volume":"34","author":"Byrne","year":"2004","journal-title":"Sports Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jnutbio.2006.10.005","article-title":"The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise","volume":"18","author":"Peake","year":"2007","journal-title":"J. Nutr. Biochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1152\/japplphysiol.00735.2002","article-title":"Antioxidants attenuate the plasma cytokine response to exercise in humans","volume":"94","author":"Vassilakopoulos","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3945\/ajcn.112.049163","article-title":"Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise","volume":"98","author":"Michailidis","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.3389\/fphys.2018.00740","article-title":"Mangifera indica l. Leaf extract in combination with luteolin or quercetin enhances vo2peak and peak power output, and preserves skeletal muscle function during ischemia-reperfusion in humans","volume":"9","author":"Wiebe","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gelabert-Rebato, M., Wiebe, J.C., Martin-Rincon, M., Galvan-Alvarez, V., Curtelin, D., Perez-Valera, M., Habib, J.J., P\u00e9rez-L\u00f3pez, A., Vega, T., and Morales-Alamo, D. (2019). Enhancement of exercise performance by 48 hours, and 15-day supplementation with mangiferin and luteolin in men. Nutrients, 11.","DOI":"10.3390\/nu11020344"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gelabert-Rebato, M., Martin-Rincon, M., Galvan-Alvarez, V., Gallego-Selles, A., Martinez-Canton, M., Vega-Morales, T., Wiebe, J.C., Fernandez-Del Castillo, C., Castilla-Hernandez, E., and Diaz-Tiberio, O. (2019). A single dose of the mango leaf extract zynamite((r)) in combination with quercetin enhances peak power output during repeated sprint exercise in men and women. Nutrients, 11.","DOI":"10.3390\/nu11112592"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1541-4337.2008.00047.x","article-title":"Major mango polyphenols and their potential significance to human health","volume":"7","author":"Masibo","year":"2008","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against d-galactosamine induced acute toxicity and oxidative\/nitrosative stress via nrf2-nfkappab pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.mehy.2014.08.021","article-title":"Mangiferin: A promising therapeutic agent for rheumatoid arthritis treatment","volume":"83","author":"Luczkiewicz","year":"2014","journal-title":"Med. Hypotheses"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"42027","DOI":"10.1038\/srep42027","article-title":"Protective effect of mangiferin on myocardial ischemia-reperfusion injury in streptozotocin-induced diabetic rats: Role of age-rage\/mapk pathways","volume":"7","author":"Suchal","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.3109\/13880209.2015.1120322","article-title":"Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity","volume":"54","author":"Niu","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s40279-015-0323-x","article-title":"Impact of dietary antioxidants on sport performance: A review","volume":"45","author":"Braakhuis","year":"2015","journal-title":"Sports Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/14756366.2016.1193735","article-title":"Quercetin protects rat skeletal muscle from ischemia reperfusion injury","volume":"31","author":"Gulcin","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.aca.2009.01.037","article-title":"Measurement of xanthine oxidase inhibition activity of phenolics and flavonoids with a modified cupric reducing antioxidant capacity (cuprac) method","volume":"636","author":"Ozyurek","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/10623320009072206","article-title":"Endothelial cell oxidant production: Effect of nadph oxidase inhibitors","volume":"7","author":"Holland","year":"2000","journal-title":"Endothelium"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s002239900467","article-title":"Bone mineral content and density in professional tennis players","volume":"62","author":"Calbet","year":"1998","journal-title":"Calcif. Tissue Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1152\/japplphysiol.01063.2016","article-title":"Measurement of the maximum oxygen uptake vo2max: Vo2peak is no longer acceptable","volume":"122","author":"Poole","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0838.2005.00448.x","article-title":"A comparison between three rating scales for perceived exertion and two different work tests","volume":"16","author":"Borg","year":"2006","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1139\/H08-026","article-title":"Effects of weight lifting training combined with plyometric exercises on physical fitness, body composition, and knee extension velocity during kicking in football","volume":"33","author":"Olmedillas","year":"2008","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_33","first-page":"26","article-title":"Reliability of jumping performance in active men and women under different stretch loading conditions","volume":"40","author":"Arteaga","year":"2000","journal-title":"J. Sports Med. Phys. Fitness"},{"key":"ref_34","first-page":"261","article-title":"Utilization of stored elastic energy in leg extensor muscles by men and women","volume":"10","author":"Komi","year":"1978","journal-title":"Med. Sci. Sports"},{"key":"ref_35","first-page":"1585","article-title":"Variation of serum and urinary neutrophil gelatinase associated lipocalin (ngal) after strenuous physical exercise","volume":"50","author":"Lippi","year":"2012","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1055\/s-0042-100281","article-title":"Susceptibility to exercise-induced muscle damage: A cluster analysis with a large sample","volume":"37","author":"Damas","year":"2016","journal-title":"Int. J. Sports Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0022-510X(83)90058-8","article-title":"Ultrastructural changes after concentric and eccentric contractions of human muscle","volume":"61","author":"Newham","year":"1983","journal-title":"J. Neurol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1152\/jappl.1991.70.6.2498","article-title":"Muscle damage induced by eccentric contractions of 25% strain","volume":"70","author":"Lieber","year":"1991","journal-title":"J. Appl. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/japplphysiol.00971.2016","article-title":"Muscle damage and inflammation during recovery from exercise","volume":"122","author":"Peake","year":"2017","journal-title":"J. Appl. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/mus.24077","article-title":"Lengthening our perspective: Morphological, cellular, and molecular responses to eccentric exercise","volume":"49","author":"Hyldahl","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1469-7793.2001.00333.x","article-title":"Muscle damage from eccentric exercise: Mechanism, mechanical signs, adaptation and clinical applications","volume":"537","author":"Proske","year":"2001","journal-title":"J. Physiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1152\/jappl.1999.87.6.2007","article-title":"Early events in stretch-induced muscle damage","volume":"87","author":"Morgan","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2165\/00007256-199927030-00002","article-title":"Exercise-induced muscle damage and potential mechanisms for the repeated bout effect","volume":"27","author":"McHugh","year":"1999","journal-title":"Sports Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2015.06.021","article-title":"Mechanisms of activation of the transcription factor nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease","volume":"88","author":"Tebay","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3159358","DOI":"10.1155\/2017\/3159358","article-title":"Antifatigue effect of luteolin-6-c-neohesperidoside on oxidative stress injury induced by forced swimming of rats through modulation of nrf2\/are signaling pathways","volume":"2017","author":"Duan","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.jnutbio.2015.08.001","article-title":"The complexity of the nrf2 pathway: Beyond the antioxidant response","volume":"26","author":"Huang","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.freeradbiomed.2014.04.021","article-title":"Trpa1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout","volume":"72","author":"Trevisan","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1476-5381.2008.00025.x","article-title":"Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: Role of a1 adenosine receptors","volume":"156","author":"Schmidt","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00421-010-1648-7","article-title":"Comparison in eccentric exercise-induced muscle damage among four limb muscles","volume":"111","author":"Chen","year":"2011","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00421-005-1345-0","article-title":"Comparison between leg and arm eccentric exercises of the same relative intensity on indices of muscle damage","volume":"95","author":"Jamurtas","year":"2005","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1152\/jappl.2000.89.6.2325","article-title":"Gender differences in muscle inflammation after eccentric exercise","volume":"89","author":"Stupka","year":"2000","journal-title":"J Appl Physiol (1985)"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Danielsson, T., Carlsson, J., Schreyer, H., Ahnesjo, J., Ten Siethoff, L., Ragnarsson, T., Tugetam, A., and Bergman, P. (2017). Blood biomarkers in male and female participants after an ironman-distance triathlon. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179324"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1139\/h00-022","article-title":"Estrogen and gender effects on muscle damage, inflammation, and oxidative stress","volume":"25","author":"Tiidus","year":"2000","journal-title":"Can. J. Appl. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1007\/s00421-015-3133-9","article-title":"The influence of estradiol on muscle damage and leg strength after intense eccentric exercise","volume":"115","author":"Minahan","year":"2015","journal-title":"Eur. J. Appl. Physiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/3\/614\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:01:53Z","timestamp":1760173313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/3\/614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,26]]},"references-count":54,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["nu12030614"],"URL":"https:\/\/doi.org\/10.3390\/nu12030614","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,26]]}}}