{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:21:19Z","timestamp":1781320879349,"version":"3.54.1"},"reference-count":44,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>This study aimed to analyse the effect of 10 weeks of a highly concentrated docosahexaenoic acid (DHA) + eicosapentaenoic (EPA) supplementation (ratio 8:1) on strength deficit and inflammatory and muscle damage markers in athletes. Fifteen endurance athletes participated in the study. In a randomized, double-blinded cross-over controlled design, the athletes were supplemented with a re-esterified triglyceride containing 2.1 g\/day of DHA + 240 mg\/day of EPA or placebo for 10 weeks. After a 4-week wash out period, participants were supplemented with the opposite treatment. Before and after each supplementation period, participants performed one eccentric-induced muscle damage exercise training session (ECC). Before, post-exercise min and 24 and 48 h after exercise, muscle soreness, knee isokinetic strength and muscle damage and inflammatory markers were tested. No significant differences in strength deficit variables were found between the two conditions in any of the testing sessions. However, a significant effect was observed in IL1\u03b2 (p = 0.011) and IL6 (p = 0.009), which showed significantly lower values after DHA consumption than after placebo ingestion. Moreover, a significant main effect was observed in CPK (p = 0.014) and LDH-5 (p = 0.05), in which significantly lower values were found after DHA + EPA consumption. In addition, there was a significant effect on muscle soreness (p = 0.049), lower values being obtained after DHA + EPA consumption. Ten weeks of re-esterified DHA + EPA promoted lower concentrations of inflammation and muscle damage markers and decreased muscle soreness but did not improve the strength deficit after an ECC in endurance athletes.<\/jats:p>","DOI":"10.3390\/nu12030719","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T05:37:34Z","timestamp":1583732254000},"page":"719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Supplementation of Re-Esteri\ufb01ed Docosahexaenoic and Eicosapentaenoic Acids Reduce Inflammatory and Muscle Damage Markers after Exercise in Endurance Athletes: A Randomized, Controlled Crossover Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8890-4244","authenticated-orcid":false,"given":"Domingo J.","family":"Ramos-Campo","sequence":"first","affiliation":[{"name":"Faculty of Sports, UCAM, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-0576","authenticated-orcid":false,"given":"Vicente","family":"\u00c1vila-Gand\u00eda","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2841-5502","authenticated-orcid":false,"given":"Fco Javier","family":"L\u00f3pez-Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Mi\u00f1arro","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Contreras","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulgencio","family":"Soto-M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6356-0836","authenticated-orcid":false,"given":"Joan C.","family":"Domingo Pedrol","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Biology, University of Barcelona, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Luque-Rubia","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology, Catholic University San Antonio, 30107 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.jnutbio.2011.09.005","article-title":"PPAR\u03b3 as a molecular target of EPA anti-inflammatory activity during TNF-\u03b1-impaired skeletal muscle cell differentiation","volume":"23","author":"Magee","year":"2012","journal-title":"J. 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