{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:18:52Z","timestamp":1776723532062,"version":"3.51.2"},"reference-count":40,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015080","name":"Fundaci\u00f3n Rafael del Pino","doi-asserted-by":"publisher","award":["C\u00e1tedra Rafael del Pino"],"award-info":[{"award-number":["C\u00e1tedra Rafael del Pino"]}],"id":[{"id":"10.13039\/501100015080","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["CTQ2016-79015-R"],"award-info":[{"award-number":["CTQ2016-79015-R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011941","name":"Gobierno del Principado de Asturias","doi-asserted-by":"publisher","award":["IDE\/2019\/000289"],"award-info":[{"award-number":["IDE\/2019\/000289"]}],"id":[{"id":"10.13039\/100011941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nutritional supplementation with antioxidants and vitamins is widely recommended in the treatment of vascular disorders affecting the retina, although there is insufficient evidence on its effectiveness. The vitamin-like compound coenzyme Q10 (CoQ10) is a nutritional supplement of current interest to treat neurodegenerative diseases. Here, we report a retrospective clinical case series study of 48 patients diagnosed with retinal vascular diseases, including non-arteritic ischemic optic neuropathy (NAION), retinal artery occlusion (RAO), and homonymous hemianopia or quadrantanopia following stroke, treated with oral supplementation with CoQ10 (100 mg per day) and vitamins. Patient follow-up was performed using the Humphrey field analyzer and 30-2 testing algorithm to determine the visual field index (VFI) and progression rates. All treated patients showed positive VFI progression rates per year: +11.5 \u00b1 15% for NAION patients (n = 18), +22 \u00b1 17% for RAO patients (n = 7), +9.3 \u00b1 10.5% for hemianopia\/quadrantanopia patients (n = 10), and +11 \u00b1 21% for patients with other conditions (n = 13). The interruption of CoQ10 supplementation in one patient resulted in a pronounced decrease of the VFI, which was partially recovered when treatment was restored. This study supports the role of CoQ10 as a nutritional therapeutic agent for vascular diseases affecting the retina. Owing to decreased VFI after interruption of CoQ10, its beneficial effects may be reversible.<\/jats:p>","DOI":"10.3390\/nu12030723","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T11:59:36Z","timestamp":1583841576000},"page":"723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Use of Vitamins and Coenzyme Q10 for the Treatment of Vascular Occlusion Diseases Affecting the Retina"],"prefix":"10.3390","volume":"12","author":[{"given":"Beatriz","family":"Fern\u00e1ndez-Vega","sequence":"first","affiliation":[{"name":"Instituto Oftalmol\u00f3gico Fern\u00e1ndez-Vega, Avda. Dres. Fern\u00e1ndez-Vega, 34, 33012 Oviedo, Spain"},{"name":"Instituto Universitario Fern\u00e1ndez-Vega (Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Universidad de Oviedo), 33012 Oviedo, Spain"},{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Avda. Juli\u00e1n Claver\u00eda, 6, 33006 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Nicieza","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Cabue\u00f1es, Los Prados, 395, 33394 Gij\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"\u00c1lvarez-Barrios","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega (Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Universidad de Oviedo), 33012 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lydia","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega (Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Universidad de Oviedo), 33012 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9983-546X","authenticated-orcid":false,"given":"Montserrat","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto Oftalmol\u00f3gico Fern\u00e1ndez-Vega, Avda. Dres. Fern\u00e1ndez-Vega, 34, 33012 Oviedo, Spain"},{"name":"Instituto Universitario Fern\u00e1ndez-Vega (Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Universidad de Oviedo), 33012 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Fern\u00e1ndez-Vega","sequence":"additional","affiliation":[{"name":"Instituto Universitario Fern\u00e1ndez-Vega (Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Universidad de Oviedo), 33012 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-0018","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Vega","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda y Biolog\u00eda Celular, Grupo SINPOS, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo, Avda. Juli\u00e1n Claver\u00eda, 6, 33006 Oviedo, Spain"},{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Chile, Calle Magdalena Vicu\u00f1a 1281, 8900000 Santiago de Chile, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-0967","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Gonz\u00e1lez-Iglesias","sequence":"additional","affiliation":[{"name":"Instituto Oftalmol\u00f3gico Fern\u00e1ndez-Vega, Avda. Dres. Fern\u00e1ndez-Vega, 34, 33012 Oviedo, Spain"},{"name":"Instituto Universitario Fern\u00e1ndez-Vega (Fundaci\u00f3n de Investigaci\u00f3n Oftalmol\u00f3gica, Universidad de Oviedo), 33012 Oviedo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.preteyeres.2008.11.002","article-title":"Ischemic optic neuropathy","volume":"28","author":"Hayreh","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00055735-200212000-00003","article-title":"Nonarteritic anterior ischemic optic neuropathy","volume":"13","author":"Buono","year":"2002","journal-title":"Curr. Opin. 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