{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:54:18Z","timestamp":1762980858463,"version":"build-2065373602"},"reference-count":61,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Several biological markers have been identified as risk factors for cardiovascular disease and are associated with increased risk of metabolic syndrome (MetS). This study provides a factual information on promising biomarkers that are associated with MetS and can aid in early detection and management of MetS in young adults of Western Algeria. We studied a total of one hundred subjects aged between thirty and forty years with MetS, in which anthropometric measurements, insulin resistance, C peptide and HbA1c, lipid profile, circulating adipokines and glucagon-like peptide-1 were measured by suitable methods, in comparison to two groups of control. MetS is closely linked to altered glucose homeostasis, the plasma insulin\/glucose ratio; i.e., the insulinogenic index helps to estimate the level of insulin secretion and also for assessing \u03b2-cell function. The correlation between homeostasis model assessment insulin resistance index (HOMA-IR) and HbA1c, body mass index or plasma triglycerides yielded positive and significant values. Biomarkers with a known and predictable association with MetS can provide a means to detect those at risk and intervene as needed. This could significantly decrease the burden complications impose on patients and the healthcare system.<\/jats:p>","DOI":"10.3390\/nu12030727","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T11:59:36Z","timestamp":1583841576000},"page":"727","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria"],"prefix":"10.3390","volume":"12","author":[{"given":"Mohammed Ilyes","family":"Belhayara","sequence":"first","affiliation":[{"name":"Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, Universit\u00e9 Oran1, 31000 Oran, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1318-3200","authenticated-orcid":false,"given":"Zoheir","family":"Mellouk","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, Universit\u00e9 Oran1, 31000 Oran, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Seddik","family":"Hamdaoui","sequence":"additional","affiliation":[{"name":"Department of internal medicine, University Hospital Institution of Oran, 31000 Oran, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malika","family":"Bachaoui","sequence":"additional","affiliation":[{"name":"Department of internal medicine, University Hospital Institution of Oran, 31000 Oran, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Kheroua","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology of Nutrition and Food Safety, Department of Biology, Faculty of Natural and Life Sciences, Universit\u00e9 Oran1, 31000 Oran, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy J.","family":"Malaisse","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Universit\u00e9 Libre de Bruxelles, B-1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"ref_1","first-page":"763","article-title":"Dietary transition and obesity in selected Arabic-speaking countries: A review of the current evidence","volume":"22","author":"Bernstein","year":"2017","journal-title":"East. 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