{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:19:38Z","timestamp":1779344378348,"version":"3.51.4"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011665","name":"Deanship of Scientific Research, King Saud University","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/501100011665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Aim: This 18 month intervention study aims to determine the efficacy of a lifestyle modification program on prediabetes reversal among Saudi adults. Methods: An 18 month randomized, multicenter trial was conducted among Saudis with prediabetes aged 25\u201360 recruited from King Salman Hospital and primary care centers in Riyadh, Saudi Arabia. A total of 180 consenting individuals were randomized (1:1) to receive either intensive lifestyle intervention (ILIG) or guidance (control group, CG). ILIG was provided with a personalized lifestyle counseling by nutritionists every 3 months to improve diet and exercise behaviors. CG was given booklets containing information on prediabetes and its prevention. Data from lifestyle assessments and laboratory measurements were analyzed at baseline and every 6 months. The primary outcome was the reversal rate of prediabetes. Results: 158 participants were analyzed (CG:85, ILIG:73) at the 12 month follow-up and 28 participants (CG:11 and ILIG:17) completed the entire 18 month study. Post-intervention, the cumulative incidence of prediabetes reversal in the ILIG was 38 participants (52.1%) which was significantly higher than CG with 26 participants (30.6%) (p = 0.02). Conclusion: A tailored lifestyle intervention is effective in reversing prediabetes, at least for a year, among Arab adults with prediabetes. The challenge of sustaining interest in adopting lifestyle changes for a longer duration should be addressed in this population.<\/jats:p>","DOI":"10.3390\/nu12030804","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T03:54:14Z","timestamp":1584590054000},"page":"804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8657-0682","authenticated-orcid":false,"given":"Osama E.","family":"Amer","sequence":"first","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Sabico","sequence":"additional","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4794-1778","authenticated-orcid":false,"given":"Hanan A.","family":"Alfawaz","sequence":"additional","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Department of Food Science and Nutrition, College of Food Science &amp; Agriculture, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naji","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Specialized Diabetes and Endocrine Center, King Fahad Medical City, Riyadh 11525, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Danish","family":"Hussain","sequence":"additional","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah M.","family":"Alnaami","sequence":"additional","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9568-6516","authenticated-orcid":false,"given":"Kaiser","family":"Wani","sequence":"additional","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-1725","authenticated-orcid":false,"given":"Nasser M.","family":"Al-Daghri","sequence":"additional","affiliation":[{"name":"Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"},{"name":"Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"IDF Diabetes Atlas Committee. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/S0140-6736(12)60283-9","article-title":"Prediabetes: A High-Risk State for Diabetes Development","volume":"379","author":"Tabak","year":"2012","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Diabetes Prevention Program Research Group (2007). The Prevalence of Retinopathy in Impaired Glucose Tolerance and Recent-Onset Diabetes in the Diabetes Prevention Program. Diabet. Med., 24, 137\u2013144.","DOI":"10.1111\/j.1464-5491.2007.02043.x"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.jacc.2009.10.060","article-title":"Pre-Diabetes and the Risk for Cardiovascular Disease: A Systematic Review of the Evidence","volume":"55","author":"Ford","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","unstructured":"World Health Organization (2005). Chapter 1- Chronic diseases: Causes and health impacts, Preventing Chronic Diseases: A Vital Investment."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/tropej\/fmu075","article-title":"The Clinical Pattern of Diabetes Insipidus in a Large University Hospital in the Middle East","volume":"61","author":"Babiker","year":"2015","journal-title":"J. Trop. Pediatr."},{"key":"ref_7","first-page":"1285","article-title":"Prevalence of Type 1 Diabetes Mellitus in Saudi Arabian Children and Adolescents","volume":"29","year":"2008","journal-title":"Saudi Med. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/2230-8229.142971","article-title":"Metabolic Syndrome: Risk Factors among Adults in Kingdom of Saudi Arabia","volume":"21","author":"Aljohani","year":"2014","journal-title":"J. Fam. Community Med."},{"key":"ref_9","first-page":"e140","article-title":"Diabetic Retinopathy and Its Risk Factors in a Society with a Type 2 Diabetes Epidemic: A Saudi National Diabetes Registry-Based Study","volume":"93","author":"Youssef","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/1474651412444143","article-title":"Diabetes: A Tale of Two Cultures","volume":"12","author":"Alzaid","year":"2012","journal-title":"Br. J. Diabetes Vasc. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/0256-4947.75773","article-title":"Prevalence of Diabetes Mellitus in a Saudi Community","volume":"31","author":"Alqurashi","year":"2011","journal-title":"Ann. Saudi Med."},{"key":"ref_12","first-page":"1603","article-title":"Diabetes Mellitus in Saudi Arabia","volume":"25","author":"Arafah","year":"2004","journal-title":"Saudi Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(08)60766-7","article-title":"The Long-Term Effect of Lifestyle Interventions to Prevent Diabetes in the China Da Qing Diabetes Prevention Study: A 20-Year Follow-up Study","volume":"371","author":"Li","year":"2008","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"537","DOI":"10.2337\/diacare.20.4.537","article-title":"Effects of Diet and Exercise in Preventing NIDDM in People with Impaired Glucose Tolerance. The Da Qing IGT and Diabetes Study","volume":"20","author":"Pan","year":"1997","journal-title":"Diabetes Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1056\/NEJMoa012512","article-title":"Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin","volume":"346","author":"Knowler","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1056\/NEJM200105033441801","article-title":"Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance","volume":"344","author":"Tuomilehto","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1016\/S0140-6736(06)69701-8","article-title":"Sustained Reduction in the Incidence of Type 2 Diabetes by Lifestyle Intervention: Follow-up of the Finnish Diabetes Prevention Study","volume":"368","author":"Lindstrom","year":"2006","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s00125-005-0097-z","article-title":"The Indian Diabetes Prevention Programme Shows That Lifestyle Modification and Metformin Prevent Type 2 Diabetes in Asian Indian Subjects with Impaired Glucose Tolerance (IDPP-1)","volume":"49","author":"Ramachandran","year":"2006","journal-title":"Diabetologia"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Al-Hamdan, R., Avery, A., Salter, A., Al-Disi, D., Al-Daghri, N.M., and McCullough, F. (2020). Identification of education models to improve health outcomes in Arab women with pre-diabetes. Nutrients, 11.","DOI":"10.3390\/nu11051113"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wani, K., Alfawaz, H., Alnaami, A.M., Sabico, S., Khattak, M.N.K., Al-Attas, O., Alokail, M.S., Alharbi, M., Chrousos, G.P., and Kumar, S. (2020). Effects of a 12-month intensive lifestyle monitoring program in predominantly overweight\/obese Arab adults with prediabetes. Nutrients, 12.","DOI":"10.3390\/nu12020464"},{"key":"ref_21","unstructured":"American Diabetes Association (2019, May 02). Standards of Medical Care in Diabetes. Diabetes Care 2017, 40, Available online: http:\/\/care.diabetesjournals.org\/content\/diacare\/suppl\/2016\/12\/15\/40.Supplement_1.DC1\/DC_40_S1_final.pdf."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.diabres.2004.06.010","article-title":"Prevention of Type 2 Diabetes by Lifestyle Intervention: A Japanese Trial in IGT Males","volume":"67","author":"Kosaka","year":"2005","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/08870440903548749","article-title":"Can the onset of type 2 diabetes be delayed by a group-based lifestyle intervention? A randomized control trial","volume":"26","author":"Moore","year":"2011","journal-title":"Psychol. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.numecd.2017.06.004","article-title":"Lower Risk of Progression from Prediabetes to Diabetes with Health Checkup with Lifestyle Education: Japan Ningen Dock Study","volume":"27","author":"Okada","year":"2017","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/oby.2004.179","article-title":"Achieving Weight and Activity Goals among Diabetes Prevention Program Lifestyle Participants","volume":"12","author":"Wing","year":"2004","journal-title":"Obes. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.2337\/dc06-0560","article-title":"Effect of Weight Loss with Lifestyle Intervention on Risk of Diabetes","volume":"29","author":"Hamman","year":"2006","journal-title":"Diabetes Care"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0140-6736(09)61457-4","article-title":"10-Year Follow-up of Diabetes Incidence and Weight Loss in the Diabetes Prevention Program Outcomes Study","volume":"374","author":"Knowler","year":"2009","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.2337\/dc09-0523","article-title":"Regression from Pre-Diabetes to Normal Glucose Regulation in the Diabetes Prevention Program","volume":"32","author":"Perreault","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1210\/jc.2004-1782","article-title":"Exercise is Required for Visceral Fat Loss in Postmenopausal Women with Type 2 Diabetes","volume":"90","author":"Giannopoulou","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2337\/diacare.17.9.961","article-title":"Obesity, Fat Distribution, and Weight Gain as Risk Factors for Clinical Diabetes in Men","volume":"17","author":"Chan","year":"1994","journal-title":"Diabetes Care"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"481","DOI":"10.7326\/0003-4819-122-7-199504010-00001","article-title":"Weight Gain as a Risk Factor for Clinical Diabetes Mellitus in Women","volume":"122","author":"Colditz","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/156482650602700207","article-title":"Evidence-Based Nutrition Recommendations for the Treatment and Prevention of Type 2 Diabetes and the Metabolic Syndrome","volume":"27","author":"Mann","year":"2006","journal-title":"Food Nutr. Bull."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00125-007-0625-0","article-title":"Metabolic Effects of Interventions to Increase Exercise in Adults with Type 2 Diabetes","volume":"50","author":"Conn","year":"2007","journal-title":"Diabetologia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/S0140-6736(12)60525-X","article-title":"Effect of Regression from Prediabetes to Normal Glucose Regulation on Long-Term Reduction in Diabetes Risk: Results from the Diabetes Prevention Program Outcomes Study","volume":"379","author":"Perreault","year":"2012","journal-title":"Lancet (Lond. Engl.)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.clnu.2018.08.009","article-title":"Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial","volume":"38","author":"Sabico","year":"2019","journal-title":"Clin. 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