{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:53:22Z","timestamp":1792511602949,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T00:00:00Z","timestamp":1584576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003624","name":"Ministry of Agriculture, Food and Rural Affairs","doi-asserted-by":"publisher","award":["Food Functionality Evaluation program"],"award-info":[{"award-number":["Food Functionality Evaluation program"]}],"id":[{"id":"10.13039\/501100003624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Gastric ulcers are a common gastrointestinal disease across the globe. Alcohol consumption is the primary cause of gastric carcinogenesis and progression. We investigated the gastroprotective effects of fermented lotus root (FL) against ethanol (EtOH)\/HCl-induced gastric ulcers in a rat model and the conceivable underlying mechanisms involved. Rats received different doses of FL (50, 100, and 200 mg\/kg) or ranitidine (positive control, 30 mg\/kg) via oral gavage daily for 14 days. One hour after the last oral administration of FL, the EtOH\/HCl mixture was orally intubated to induce gastric damage. Oral administration of FL significantly alleviated the gastric lesions. Moreover, FL also elevated the amounts of nitric oxide and the antioxidant enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase in the stomach. To verify the gastric mucosal defense mechanism, inflammation-related genes were measured. Our results revealed that FL effectively inhibited gastric mucosal damage via downregulation of the nuclear factor-kappaB (NF-\u03baB) response in the stomach. The administration of FL significantly lowered the gastric mRNA expression of inflammation-related genes, including NF-\u03bab1, tumor necrosis factor-\u03b1, interferon \u03b3, and prostaglandin-endoperoxide synthase 2, compared with the gastric ulcer control group. In addition, the NF-\u03baB signaling pathway-related protein markers inhibitor of \u03baB (I\u03baB)-\u03b1, I\u03baB kinase, and NF-\u03baB were significantly reduced in the FL groups. Taken together, these data suggest that FL administration may have potential as an alternative treatment for gastric ulcers due to its antioxidant and anti-inflammatory effects and its ability to promote the recovery of gastric mucosa.<\/jats:p>","DOI":"10.3390\/nu12030808","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T03:54:14Z","timestamp":1584590054000},"page":"808","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Gastroprotective Effects of Fermented Lotus Root against Ethanol\/HCl-Induced Gastric Mucosal Acute Toxicity in Rats"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4014-3789","authenticated-orcid":false,"given":"Jeong-Hyun","family":"Yoo","sequence":"first","affiliation":[{"name":"Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2778-1834","authenticated-orcid":false,"given":"Eun-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea"},{"name":"Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6138-6520","authenticated-orcid":false,"given":"So Hyeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8353-3619","authenticated-orcid":false,"given":"Hae-Jeung","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute for Aging and Clinical Nutrition Research, Gachon University, Gyeonggi-do 13120, Korea"},{"name":"Department of Food and Nutrition, Gachon University, Gyeonggi-do 13120, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Morsy, M., and El-Sheikh, A. 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