{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T03:54:14Z","timestamp":1783137254609,"version":"3.54.6"},"reference-count":84,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Beside skeletal system maintenance and protection, possible extra-calcium roles of vitamin D have been recently described. In particular, studies have investigated possible roles of vitamin D as a key modulator of inflammation and immune mechanisms and of the intestinal mucosa barrier. In this regard, vitamin D has been considered as a factor that affects different conditions such as immune-mediated diseases. The new emerging role of vitamin D and its involvement in immune modulation has led it to be considered as a possible key factor involved in celiac disease (CD) onset. CD is a chronic immune-mediated enteropathy of the small intestine that is triggered by dietary gluten protein exposure in individuals who are genetically predisposed. However, along with gluten, other environmental factors are also involved in CD onset. The renewed interest in a molecule that offers great possibilities for new roles has led to an increase in studies, although there remains a lack of studies aimed at contextualizing the role of vitamin D on CD. This review aims to define the possible role of vitamin D in CD onset as it is presently understood, taking into account potential links among vitamin D, the immune system and CD.<\/jats:p>","DOI":"10.3390\/nu12041051","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T04:45:31Z","timestamp":1586753131000},"page":"1051","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Possible Role of Vitamin D in Celiac Disease Onset"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-7713","authenticated-orcid":false,"given":"Giorgia","family":"Vici","sequence":"first","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1090-8744","authenticated-orcid":false,"given":"Dalia","family":"Camilletti","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Polzonetti","sequence":"additional","affiliation":[{"name":"School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00109-010-0590-9","article-title":"Vitamin D and molecular actions on the immune system: Modulation of innate and autoimmunity","volume":"88","author":"Kamen","year":"2010","journal-title":"J. Mol. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Barrea, L., Muscogiuri, G., Laudisio, D., Di Somma, C., Salzano, C., Pugliese, G., de Alteriis, G., Colao, A., and Savastano, S. (2019). Phase angle: A possible biomarker to quantify inflammation in subjects with obesity and 25 (OH) D deficiency. Nutrients, 11.","DOI":"10.3390\/nu11081747"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11154-017-9411-6","article-title":"Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist","volume":"18","author":"Barrea","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.isci.2019.06.026","article-title":"Vitamin D\/Vitamin D Receptor Signaling Is Required for Normal Development and Function of Group 3 Innate Lymphoid Cells in the Gut","volume":"17","author":"He","year":"2019","journal-title":"iScience"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11154-016-9405-9","article-title":"Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept","volume":"18","author":"Altieri","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102350","DOI":"10.1016\/j.autrev.2019.102350","article-title":"Emerging role of vitamin D in autoimmune diseases: An update on evidence and therapeutic implications","volume":"18","author":"Murdaca","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.3389\/fimmu.2018.03160","article-title":"Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/08916930500288455","article-title":"Heterogeneity of vitamin D receptor gene association with celiac disease and type 1 diabetes mellitus","volume":"38","author":"Bilbao","year":"2005","journal-title":"Autoimmunity"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Marild, K., Tapia, G., Haugen, M., Dahl, S.R., Cohen, A.S., Lundqvist, M., Lie, B.A., Stene, L.C., and Stordal, K. (2017). Maternal and neonatal vitamin D status, genotype and childhood celiac disease. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0179080"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"619381","DOI":"10.1155\/2012\/619381","article-title":"Solar radiation and vitamin D: Mitigating environmental factors in autoimmune disease","volume":"2012","author":"Schwalfenberg","year":"2012","journal-title":"J. Environ. Public Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/07853890.2013.849383","article-title":"Appropriate nutrient supplementation in celiac disease","volume":"45","author":"Caruso","year":"2013","journal-title":"Ann. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.clnu.2016.05.002","article-title":"Gluten free diet and nutrient deficiencies: A review","volume":"35","author":"Vici","year":"2016","journal-title":"Clin. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1586\/17474124.2014.876360","article-title":"Nutritional consequences of celiac disease and the gluten-free diet","volume":"8","author":"Theethira","year":"2014","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1017\/S1368980013003510","article-title":"Early-life vitamin D deficiency and childhood-onset coeliac disease","volume":"17","author":"Tanpowpong","year":"2014","journal-title":"Public Health Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.yapd.2008.07.001","article-title":"Celiac disease: Pathophysiology, clinical manifestations, and associated autoimmune conditions","volume":"55","author":"Barker","year":"2008","journal-title":"Adv. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Caio, G., Volta, U., Sapone, A., Leffler, D.A., De Giorgio, R., Catassi, C., and Fasano, A. (2019). Celiac disease: A comprehensive current review. BMC Med., 17.","DOI":"10.1186\/s12916-019-1380-z"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lerner, A., Agmon-Levin, N., Shapira, Y., Gilburd, B., Reuter, S., Lavi, I., and Shoenfeld, Y. (2013). The thrombophilic network of autoantibodies in celiac disease. BMC Med., 11.","DOI":"10.1186\/1741-7015-11-89"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.3748\/wjg.v23.i42.7505","article-title":"Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota - Key players in the pathogenesis of celiac disease","volume":"23","author":"Cukrowska","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_19","unstructured":"Yakovlevich, K.L., Valerievna, S.M., Aleksandrovna, K.V., Nicolaevna, Z.I., Arturovna, A.R., Valerievna, Z.E., Dmitrievna, K.L., and Victorovna, I.A. (2019). Genetic Characteristics of Children with Celiac Disease Living in the South of Russia. Me\u0434u\u0446u\u043dc\u043au\u0439 \u0432ecm\u043du\u043a Ce\u0432e\u0440\u043do\u0433o K\u0430\u0432\u043a\u0430\u0437\u0430, 14."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Niro, S., D\u2018Agostino, A., Fratianni, A., Cinquanta, L., and Panfili, G. (2019). Gluten-Free Alternative Grains: Nutritional Evaluation and Bioactive Compounds. Foods, 8.","DOI":"10.3390\/foods8060208"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1038\/ctg.2016.54","article-title":"Human intestinal barrier function in health and disease","volume":"7","author":"Wells","year":"2016","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Delbue, D., Cardoso-Silva, D., Branchi, F., Itzlinger, A., Letizia, M., Siegmund, B., and Schumann, M. (2019). Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225597"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5114\/aoms.2018.72241","article-title":"Histologic recovery among children with celiac disease on a gluten-free diet. A long-term follow-up single-center experience","volume":"14","author":"Belei","year":"2018","journal-title":"Arch. Med. Sci. AMS"},{"key":"ref_24","first-page":"3","article-title":"Antinuclear Antibodies Patterns in Patients with Celiac Disease","volume":"1","author":"Almeida","year":"2019","journal-title":"Biomed. J."},{"key":"ref_25","first-page":"19","article-title":"Can celiac disease present along with childhood obesity","volume":"5","author":"Livshits","year":"2017","journal-title":"Int. J. Celiac. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Popp, A., and M\u00e4ki, M. (2019). Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease\u2014Celiac Trait. Nutrients, 11.","DOI":"10.3390\/nu11020320"},{"key":"ref_27","first-page":"24","article-title":"Extraintestinal manifestations of CD: Common pathways in the gut-remote organs\u2019 axes","volume":"5","author":"Lerner","year":"2017","journal-title":"Intern. J. Celiac. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1542\/peds.2014-3675","article-title":"Clinical features of celiac disease: A prospective birth cohort","volume":"135","author":"Agardh","year":"2015","journal-title":"Pediatrics"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1001\/jama.2019.10329","article-title":"Association of gluten intake during the first 5 years of life with incidence of celiac disease autoimmunity and celiac disease among children at increased risk","volume":"322","author":"Aronsson","year":"2019","journal-title":"JAMA"},{"key":"ref_30","first-page":"1285","article-title":"The missing environmental factor in celiac disease","volume":"371","author":"Ludvigsson","year":"2014","journal-title":"J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.giec.2012.07.003","article-title":"Pathophysiology of celiac disease","volume":"22","author":"Kupfer","year":"2012","journal-title":"Gastrointest Endosc. Clin."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.jpeds.2012.08.056","article-title":"Multicenter study on season of birth and celiac disease: Evidence for a new theoretical model of pathogenesis","volume":"162","author":"Tanpowpong","year":"2013","journal-title":"J. Pediatrics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MOP.0000000000000451","article-title":"Vitamin D in pediatric gastrointestinal disease","volume":"29","author":"Ahlawat","year":"2017","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3390\/nu5072502","article-title":"Vitamin D and immune function","volume":"5","author":"Prietl","year":"2013","journal-title":"Nutrients"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S86","DOI":"10.1097\/MCG.0000000000001112","article-title":"Vitamin D: Immunomodulatory Aspects","volume":"52","author":"Miraglia","year":"2018","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.3748\/wjg.v21.i17.5191","article-title":"Role of vitamins in gastrointestinal diseases","volume":"21","author":"Masri","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"106112","DOI":"10.1016\/j.intimp.2019.106112","article-title":"Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects","volume":"79","author":"Malaguarnera","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10620-017-4738-0","article-title":"Protective Effect of 1,25-Dihydroxy Vitamin D3 on Pepsin-Trypsin-Resistant Gliadin-Induced Tight Junction Injuries","volume":"63","author":"Dong","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/08830185.2011.602443","article-title":"New clues in celiac disease epidemiology, pathogenesis, clinical manifestations, and treatment","volume":"30","author":"Lionetti","year":"2011","journal-title":"Int. Rev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1357-2725(03)00239-5","article-title":"The pathogenesis of coeliac disease","volume":"36","author":"Dewar","year":"2004","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/nu4040243","article-title":"Celiac disease, inflammation and oxidative damage: A nutrigenetic approach","volume":"4","author":"Ferretti","year":"2012","journal-title":"Nutrients"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Fasano, A. (2020). All disease begins in the (leaky) gut: Role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Research.","DOI":"10.12688\/f1000research.20510.1"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Lammers, K.M., Lu, R., Brownley, J., Lu, B., Gerard, C., Thomas, K., Rallabhandi, P., Shea-Donohue, T., Tamiz, A., and Alkan, S. (2008). Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology, 135.","DOI":"10.1053\/j.gastro.2008.03.023"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2567.2010.03378.x","article-title":"Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease","volume":"132","author":"Lammers","year":"2011","journal-title":"Immunology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.cgh.2012.08.012","article-title":"Intestinal permeability and its regulation by zonulin: Diagnostic and therapeutic implications","volume":"10","author":"Fasano","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.4049\/jimmunol.176.4.2512","article-title":"Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: Role of the innate immune response in Celiac disease","volume":"176","author":"Thomas","year":"2006","journal-title":"J. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1097\/MIB.0000000000000526","article-title":"1, 25-Dihydroxyvitamin D protects intestinal epithelial barrier by regulating the myosin light chain kinase signaling pathway","volume":"21","author":"Du","year":"2015","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jsbmb.2010.03.037","article-title":"Human T lymphocytes are direct targets of 1, 25-dihydroxyvitamin D3 in the immune system","volume":"121","author":"Baeke","year":"2010","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3389\/fimmu.2019.00600","article-title":"1, 25-Dihydroxyvitamin D3 restrains CD4+ T cell priming ability of CD11c+ dendritic cells by upregulating expression of CD31","volume":"10","author":"Saul","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/dmrr.1275","article-title":"1, 25-Dihydroxyvitamin D3 alters murine dendritic cell behaviour in vitro and in vivo","volume":"27","author":"Ferreira","year":"2011","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zhao, H., Zhang, H., Wu, H., Li, H., Liu, L., Guo, J., Li, C., Shih, D.Q., and Zhang, X. (2012). Protective role of 1, 25 (OH) 2 vitamin D 3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice. BMC Gastroenterol., 12.","DOI":"10.1186\/1471-230X-12-57"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.toxlet.2015.06.006","article-title":"Protective effect of 1, 25-dihydroxyvitamin D3 on ethanol-induced intestinal barrier injury both in vitro and in vivo","volume":"237","author":"Chen","year":"2015","journal-title":"Toxicol. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.bbrc.2015.03.125","article-title":"1, 25-Dihydroxyvitamin D3 preserves intestinal epithelial barrier function from TNF-\u03b1 induced injury via suppression of NF-kB p65 mediated MLCK-P-MLC signaling pathway","volume":"460","author":"Chen","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5796491","DOI":"10.1155\/2019\/5796491","article-title":"Escherichia coli Nissle 1917 Protects Intestinal Barrier Function by Inhibiting NF-\u03baB-Mediated Activation of the MLCK-P-MLC Signaling Pathway","volume":"2019","author":"Guo","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/jech.57.1.36","article-title":"Children born in the summer have increased risk for coeliac disease","volume":"57","author":"Ivarsson","year":"2003","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/MPG.0b013e3181709530","article-title":"Seasonality of birth month of children with celiac disease differs from that in the general population and between sexes and is linked to family history and environmental factors","volume":"48","author":"Lewy","year":"2009","journal-title":"J. Pediatric Gastroenterol. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1136\/archdischild-2012-302360","article-title":"Season of birth in a nationwide cohort of coeliac disease patients","volume":"98","author":"Lebwohl","year":"2013","journal-title":"Arch. Dis. Child."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1053\/j.gastro.2017.02.012","article-title":"Lower prevalence of celiac disease and gluten-related disorders in persons living in southern vs northern latitudes of the United States","volume":"152","author":"Ruhl","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00431-015-2589-2","article-title":"Impact of the birth's season on the development of celiac disease in Italy","volume":"174","author":"Capriati","year":"2015","journal-title":"Eur. J. Pediatr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1744-6155.2011.00280.x","article-title":"Vitamin D status and supplementation in pediatric gastrointestinal disease","volume":"16","author":"Heuberger","year":"2011","journal-title":"J. Spec. Pediatric Nurs."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/MPG.0000000000000368","article-title":"Is it necessary to assess for fat-soluble vitamin deficiencies in pediatric patients with newly diagnosed celiac disease?","volume":"59","author":"Imam","year":"2014","journal-title":"J. Pediatric Gastroenterol. Nutr."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1515\/jpem-2012-0048","article-title":"Is vitamin D deficiency a feature of pediatric celiac disease?","volume":"25","author":"Villanueva","year":"2012","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12016-010-8237-8","article-title":"The clinical significance of 25OH-Vitamin D status in celiac disease","volume":"42","author":"Lerner","year":"2012","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/MCG.0b013e318266f81b","article-title":"Vitamin D status and concomitant autoimmunity in celiac disease","volume":"47","author":"Tavakkoli","year":"2013","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/MPG.0000000000001475","article-title":"Serum vitamins and minerals at diagnosis and follow-up in children with celiac disease","volume":"65","author":"Deora","year":"2017","journal-title":"J. Pediatric Gastroenterol. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/MPG.0000000000002417","article-title":"Should We Assess Vitamin D Status in Pediatric Patients With Celiac Disease?","volume":"69","author":"Ahlawat","year":"2019","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11657-018-0554-1","article-title":"Celiac disease and severe vitamin D deficiency: The case for anti-tissue transglutaminase antibody screening","volume":"14","author":"Sulimani","year":"2019","journal-title":"Arch. Osteoporos."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bittker, S. (2015). Exposure to excessive oral vitamin D in youth: A risk factor for celiac disease in later life. J. Allergy Asthma, 2.","DOI":"10.7243\/2054-9873-2-2"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CEG.S222353","article-title":"Elevated Levels of 1, 25-Dihydroxyvitamin D in Plasma as a Missing Risk Factor for Celiac Disease","volume":"13","author":"Bittker","year":"2020","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/CEG.S210060","article-title":"Potential risk factors for celiac disease in childhood: A case-control epidemiological survey","volume":"12","author":"Bittker","year":"2019","journal-title":"Clin. Exp. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1017\/S0007114517000332","article-title":"Maternal use of dietary supplements during pregnancy is not associated with coeliac disease in the offspring: The Environmental Determinants of Diabetes in the Young (TEDDY) study","volume":"117","author":"Yang","year":"2017","journal-title":"Br. J. Nutr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline","volume":"96","author":"Holick","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4081\/itjm.2015.597","article-title":"Potential role of vitamin D in prevention of skeletal and extraskeletal diseases in older people","volume":"10","author":"Montagnani","year":"2015","journal-title":"Ital. J. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1002\/jbmr.3442","article-title":"25-Hydroxyvitamin D threshold for the effects of vitamin D supplements on bone density: Secondary analysis of a randomized controlled trial","volume":"33","author":"Macdonald","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"American College of Gastroenterology clinical guideline: Diagnosis and management of celiac disease","volume":"108","author":"Hill","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/MPG.0000000000001216","article-title":"NASPGHAN clinical report on the diagnosis and treatment of gluten-related disorders","volume":"63","author":"Hill","year":"2016","journal-title":"J. Pediatric Gastroenterol. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13052-018-0488-7","article-title":"Vitamin D in pediatric age: Consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians","volume":"44","author":"Saggese","year":"2018","journal-title":"Ital. J. Pediatrics"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e20153147","DOI":"10.1542\/peds.2015-3147","article-title":"Evidence-informed expert recommendations for the management of celiac disease in children","volume":"138","author":"Snyder","year":"2016","journal-title":"Pediatrics"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"h4513","DOI":"10.1136\/bmj.h4513","article-title":"Recognition, assessment, and management of coeliac disease: Summary of updated NICE guidance","volume":"351","author":"Downey","year":"2015","journal-title":"Bmj"},{"key":"ref_81","unstructured":"Institute of Medicine, Food and Nutrition Board, Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Ross, A.C., Taylor, C.L., Yaktine, A.L., and Del Valle, H.B. (2011). Dietary Reference Intakes for Calcium and Vitamin D, National Academies Press."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, and Nutrition and Allergies (NDA) (2016). Dietary reference values for vitamin D. EFSA J., 14, e04547.","DOI":"10.2903\/j.efsa.2016.4547"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic Products, and Nutrition and Allergies (NDA) (2012). Scientific opinion on the tolerable upper intake level of vitamin D. EFSA J., 10, 2813.","DOI":"10.2903\/j.efsa.2012.2813"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"EFSA Panel on Dietetic, Products, Nutrition and Allergies (EFSA NDA, Panel), Turck, D., Bresson, J.L., Burlingame, B., Dean, T., Fairweather-Tait, S., Heinonen, M., Hirsch-Ernst, K.I., and Mangelsdorf, I. (2018). Update of the tolerable upper intake level for vitamin D for infants. 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