{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:09:12Z","timestamp":1789826952338,"version":"4.0.1"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005758","name":"Universit\u00e0 Politecnica delle Marche","doi-asserted-by":"publisher","award":["Scientific research grant, years 2016-2017-2018"],"award-info":[{"award-number":["Scientific research grant, years 2016-2017-2018"]}],"id":[{"id":"10.13039\/501100005758","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IRCCS INRCA","award":["Ricerca corrente grant"],"award-info":[{"award-number":["Ricerca corrente grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In this randomized, double-blind, single-center trial (ANZCTR number ACTRN12619000436178) we aimed to investigate changes in endothelium-dependent vasodilation induced by ubiquinol, the reduced form of coenzyme Q10 (CoQ10), in healthy subjects with moderate dyslipidemia. Fifty-one subjects with low-density lipoprotein (LDL) cholesterol levels of 130\u2013200 mg\/dL, not taking statins or other lipid lowering treatments, moderate (2.5%\u20136.0%) endothelial dysfunction as measured by flow-mediated dilation (FMD) of the brachial artery, and no clinical signs of cardiovascular disease were randomized to receive either ubiquinol (200 or 100 mg\/day) or placebo for 8 weeks. The primary outcome measure was the effect of ubiquinol supplementation on FMD at the end of the study. Secondary outcomes included changes in FMD on week 4, changes in total and oxidized plasma CoQ10 on week 4 and week 8, and changes in serum nitrate and nitrite levels (NOx), and plasma LDL susceptibility to oxidation in vitro on week 8. Analysis of the data of the 48 participants who completed the study demonstrated a significantly increased FMD in both treated groups compared with the placebo group (200 mg\/day, +1.28% \u00b1 0.90%; 100 mg\/day, +1.34% \u00b1 1.44%; p &lt; 0.001) and a marked increase in plasma CoQ10, either total (p &lt; 0.001) and reduced (p &lt; 0.001). Serum NOx increased significantly and dose-dependently in all treated subjects (p = 0.016), while LDL oxidation lag time improved significantly in those receiving 200 mg\/day (p = 0.017). Ubiquinol significantly ameliorated dyslipidemia-related endothelial dysfunction. This effect was strongly related to increased nitric oxide bioavailability and was partly mediated by enhanced LDL antioxidant protection.<\/jats:p>","DOI":"10.3390\/nu12041098","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T05:15:41Z","timestamp":1587014141000},"page":"1098","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-6778","authenticated-orcid":false,"given":"Jacopo","family":"Sabbatinelli","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Galeazzi","sequence":"additional","affiliation":[{"name":"Clinical Laboratory and Molecular Diagnostics, IRCCS INRCA, Via della Montagnola 81, 60127 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3302-4335","authenticated-orcid":false,"given":"Sonia","family":"Silvestri","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-5426","authenticated-orcid":false,"given":"Ilenia","family":"Cirilli","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Marcheggiani","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5965-3610","authenticated-orcid":false,"given":"Phiwayinkosi V.","family":"Dludla","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"},{"name":"Biomedical Research and Innovation Platform, South African Medical Research Council, P.O. Box 19070, Tygerberg, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8477-8519","authenticated-orcid":false,"given":"Angelica","family":"Giuliani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Bonfigli","sequence":"additional","affiliation":[{"name":"Scientific Direction, IRCCS INRCA, Via della Montagnola 81, 60127 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Biology and Biochemistry Section, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-1144","authenticated-orcid":false,"given":"Fabiola","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences, Universit\u00e0 Politecnica delle Marche, Via Tronto 10\/A, 60126 Ancona, Italy"},{"name":"Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Antonicelli","sequence":"additional","affiliation":[{"name":"Cardiology Unit, IRCCS INRCA, Via della Montagnola 81, 60127 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-7106","authenticated-orcid":false,"given":"Luca","family":"Tiano","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Universit\u00e0 Politecnica delle Marche, Via Ranieri 65, 60128 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(07)61778-4","article-title":"Blood cholesterol and vascular mortality by age, sex, and blood pressure: A meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths","volume":"370","author":"Lewington","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1001\/archinte.164.10.1066","article-title":"Prevalence of the metabolic syndrome and its relation to all-cause and cardiovascular mortality in nondiabetic European men and women","volume":"164","author":"Hu","year":"2004","journal-title":"Arch. 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