{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:48:32Z","timestamp":1785865712238,"version":"3.56.0"},"reference-count":56,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T00:00:00Z","timestamp":1587945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A6A1A06015181"],"award-info":[{"award-number":["NRF-2017R1A6A1A06015181"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002628","name":"Incheon National University","doi-asserted-by":"publisher","award":["Incheon National University Research Grant in 2017"],"award-info":[{"award-number":["Incheon National University Research Grant in 2017"]}],"id":[{"id":"10.13039\/501100002628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Pyropia yezoensis, a red alga, is popular and harvested a lot in East Asia and is famous for its medicinal properties attributable to its bioactive compounds including amino acids (porphyra-334 and shinorine, etc.), polysaccharides, phytosterols, and pigments, but its anti-inflammatory effect and mechanism of anti-atopic dermatitis (AD) have not been elucidated. In this study, we investigate the anti-AD effect of P. yezoensis extract (PYE) on mRNA and protein levels of the pro-inflammatory chemokines, thymus, and activation-regulated chemokine (TARC\/CCL17) and macrophage-derived chemokine (MDC\/CCL22), in human HaCaT keratinocyte cells treated to interferon (IFN)-\u03b3 or tumor necrosis factor (TNF)-\u03b1 (10 ng\/mL each). The effect of the PYE on extracellular signal-regulated kinase (ERK) and other mitogen-activated protein kinases (MAPKs) was related to its suppression of TARC and MDC production by blocking NF-\u03baB activation in HaCaT cells. Furthermore, astaxanthin and xanthophyll from P. yezoensis were identified as anti-AD candidate compounds. These results suggest that the PYE may improve AD and contained two carotenoids by regulating pro-inflammatory chemokines.<\/jats:p>","DOI":"10.3390\/nu12051238","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T05:05:32Z","timestamp":1588050332000},"page":"1238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pyropia yezoensis Extract Suppresses IFN-Gamma- and TNF-Alpha-Induced Proinflammatory Chemokine Production in HaCaT Cells via the Down-Regulation of NF-\u03baB"],"prefix":"10.3390","volume":"12","author":[{"given":"Yuna","family":"Ha","sequence":"first","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"},{"name":"Department of Cosmetic Science and Management, Graduate school, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Hwi","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"},{"name":"Department of Marine Sciences, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JaeWoo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"},{"name":"Department of Cosmetic Science and Management, Graduate school, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Park","sequence":"additional","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Young","family":"Ko","sequence":"additional","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oh Wook","family":"Kwon","sequence":"additional","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jongsung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon City, Gyunggi Do 164-19, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-8506","authenticated-orcid":false,"given":"Youn-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Korea"},{"name":"Department of Cosmetic Science and Management, Graduate school, Incheon National University, Incheon 22012, Korea"},{"name":"Department of Marine Sciences, Incheon National University, Incheon 22012, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1067\/mai.2000.106484","article-title":"Atopic dermatitis: New insights and opportunities for therapeutic intervention","volume":"105","author":"Leung","year":"2000","journal-title":"J. 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