{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:54:53Z","timestamp":1786967693051,"version":"build-2736575974"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stiftung Lebensblicke","award":["Stiftung Lebensblicke"],"award-info":[{"award-number":["Stiftung Lebensblicke"]}]},{"DOI":"10.13039\/100017403","name":"Matthias Lackas Foundation","doi-asserted-by":"publisher","award":["Matthias Lackas Foundation"],"award-info":[{"award-number":["Matthias Lackas Foundation"]}],"id":[{"id":"10.13039\/100017403","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the ERA-NET on Translational Cancer Research (TRANSCAN)","award":["project 01KT1503 (FOCUS consortium)"],"award-info":[{"award-number":["project 01KT1503 (FOCUS consortium)"]}]},{"name":"National Cancer Institute project","award":["R01 CA189184"],"award-info":[{"award-number":["R01 CA189184"]}]},{"name":"National Cancer Institute projects NIH","award":["R01 CA 189184 and NIH U01 CA 206110"],"award-info":[{"award-number":["R01 CA 189184 and NIH U01 CA 206110"]}]},{"name":"National Cancer Institute projects NIH","award":["NIH R01 CA207371 and P30 CA042014"],"award-info":[{"award-number":["NIH R01 CA207371 and P30 CA042014"]}]},{"DOI":"10.13039\/100010637","name":"Huntsman Cancer Foundation","doi-asserted-by":"publisher","award":["Huntsman Cancer Foundation"],"award-info":[{"award-number":["Huntsman Cancer Foundation"]}],"id":[{"id":"10.13039\/100010637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["project NIH U01 CA 206110"],"award-info":[{"award-number":["project NIH U01 CA 206110"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA160684 and R01 CA215134."],"award-info":[{"award-number":["R01 CA160684 and R01 CA215134."]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Consortium of Translational Cancer Research (DKTK)","award":["German Consortium of Translational Cancer Research (DKTK)"],"award-info":[{"award-number":["German Consortium of Translational Cancer Research (DKTK)"]}]},{"name":"TRANSCAN grant 01KT1503","award":["TRANSCAN grant 01KT1503"],"award-info":[{"award-number":["TRANSCAN grant 01KT1503"]}]},{"name":"institutional funding from the Division of General, Visceral and Transplantation Surgery, University of Heidelberg","award":["institutional funding from the Division of General, Visceral and Transplantation Surgery, University of Heidelberg"],"award-info":[{"award-number":["institutional funding from the Division of General, Visceral and Transplantation Surgery, University of Heidelberg"]}]},{"name":"institutional funding from the German Cancer Research Center (DKFZ","award":["institutional funding from the German Cancer Research Center (DKFZ"],"award-info":[{"award-number":["institutional funding from the German Cancer Research Center (DKFZ"]}]},{"name":"institutional funding from the Division of Preventive Oncology","award":["institutional funding from the Division of Preventive Oncology"],"award-info":[{"award-number":["institutional funding from the Division of Preventive Oncology"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (\u03b2 = 0.06, p = 0.04 and \u03b2 = 0.07, p = 0.01) and with worse social functioning six months post-surgery (\u03b2 = \u22120.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (\u03b2 = 1.03, p &lt; 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.<\/jats:p>","DOI":"10.3390\/nu12051247","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T09:57:21Z","timestamp":1588067841000},"page":"1247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Biljana","family":"Gigic","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany"},{"name":"Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7641-059X","authenticated-orcid":false,"given":"Johanna","family":"Nattenm\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Kulu","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Syrjala","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Schrotz-King","sequence":"additional","affiliation":[{"name":"Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Preventive Oncology, National Center for Tumor Diseases and German Cancer Research Center, 69120 Heidelberg, Germany"},{"name":"Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, 69120 Heidelberg, Germany"},{"name":"German Cancer Consortium (DKTK), German Cancer Research Center, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"Colditz","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane C.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Grady","sequence":"additional","affiliation":[{"name":"Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"},{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"},{"name":"Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Li","sequence":"additional","affiliation":[{"name":"Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Tennessee Health Science Center, Memphis, TN 38163, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adetunji T.","family":"Toriola","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"Kauczor","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Population Sciences, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA"},{"name":"Department of Population Health Sciences, University of Utah, Salt Lake City, UT 84112, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/ijc.31937","article-title":"Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods","volume":"144","author":"Ferlay","year":"2019","journal-title":"Int. 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