{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:14:34Z","timestamp":1782792874324,"version":"3.54.5"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Eckol, a precursor compound belonging to the dibenzo-1,4-dioxin class of phlorotannins, is a phloroglucinol derivative that exerts various activities. In the present study, we investigated the antiallergic effects of eckol isolated from the marine brown algae, Ecklonia cava using immunoglobulin E (IgE)\/bovine serum albumin (BSA)-stimulated mouse bone marrow-derived cultured mast cells (BMCMC) and a mouse model of anaphylaxis. Eckol inhibited IgE\/BSA-induced BMCMC degranulation by reducing \u03b2-hexosaminidase release. A flow cytometric analysis revealed that eckol decreases Fc\u03b5RI expression on cell surface and IgE binding to the Fc\u03b5RI in BMCMC. Moreover, eckol suppressed the production of the cytokines, interleukin (IL)-4, IL-5, IL-6, and IL-13 and the chemokine, thymus activation-regulated chemokine (TARC) by downregulating, I\u03baB-\u03b1 degradation and NF-\u03baB nuclear translocation. Furthermore, it attenuated the passive cutaneous anaphylactic reaction induced by IgE\/BSA-stimulation in the ear of BALB\/c mice. These results suggest that eckol is a potential therapeutic candidate for the prevention and treatment of allergic disorders.<\/jats:p>","DOI":"10.3390\/nu12051361","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T10:01:18Z","timestamp":1589191278000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Eckol from Ecklonia cava Suppresses Immunoglobulin E-mediated Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice"],"prefix":"10.3390","volume":"12","author":[{"given":"Eui","family":"Han","sequence":"first","affiliation":[{"name":"Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"National Marine Biodiversity Institute of Korea, 75, Jangsan-ro 101 gil, Janghang-eup, Seocheon 33662, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7073-995X","authenticated-orcid":false,"given":"K.K.A.","family":"Sanjeewa","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.I.N.M.","family":"Herath","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-7266","authenticated-orcid":false,"given":"You-Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngheun","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjun","family":"Lee","sequence":"additional","affiliation":[{"name":"Naturetech, 29-8, Yongjeong-gil, Chopyeong-myeon, Jincheon-gun, Chungbuk 27858, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taehee","family":"Kim","sequence":"additional","affiliation":[{"name":"Naturetech, 29-8, Yongjeong-gil, Chopyeong-myeon, Jincheon-gun, Chungbuk 27858, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Yup","family":"Shim","sequence":"additional","affiliation":[{"name":"Fisheries Science Institute, Chonnam National University, Daehak-Ro, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ginnae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Food Technology and Nutrition, Chonnam National University, Yeosu 59626, Korea"},{"name":"Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu 59626, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"key":"ref_1","first-page":"61","article-title":"Metabolites of marine algae collected from Karachi-coasts of Arabian Sea","volume":"6","author":"Muhammad","year":"2000","journal-title":"Nat. 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