{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:14:55Z","timestamp":1783541695675,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The HELENA Trial was sponsored by the Helmholtz Association of German Research Centers","award":["Cross-Program Topic: Metabolic Dysfunction."],"award-info":[{"award-number":["Cross-Program Topic: Metabolic Dysfunction."]}]},{"name":"Magnetic resonance imaging examinations were performed in the Department of Diagnostic and Interventional Radiology, Heidelberg University Hospital, and sponsored by the Max Grundig Foundation","award":["Max Grundig Foundation"],"award-info":[{"award-number":["Max Grundig Foundation"]}]},{"name":"Publication fee was sponsored by the Max Grundig Foundation","award":["Publication fee was sponsored by the Max Grundig Foundation"],"award-info":[{"award-number":["Publication fee was sponsored by the Max Grundig Foundation"]}]},{"name":"C.M.U has cancer center director oversight over research funded by several pharmaceutical companies but has not received funding directly herself.","award":["C.M.U has cancer center director oversight over research funded by several pharmaceutical companies but has not received funding directly herself."],"award-info":[{"award-number":["C.M.U has cancer center director oversight over research funded by several pharmaceutical companies but has not received funding directly herself."]}]},{"name":"C.M.U was funded by the Huntsman Cancer Foundation","award":["C.M.U was funded by the Huntsman Cancer Foundation"],"award-info":[{"award-number":["C.M.U was funded by the Huntsman Cancer Foundation"]}]},{"name":"C.M.U was funded by the National Cancer Institute","award":["R01 CA189184, R01 CA207371, U01 CA206110, and P30 CA042014"],"award-info":[{"award-number":["R01 CA189184, R01 CA207371, U01 CA206110, and P30 CA042014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Background: Bone marrow fat is implicated in metabolism, bone health and haematological diseases. Thus, this study aims to analyse the impact of moderate weight loss on bone marrow fat content (BMFC) in obese, healthy individuals. Methods: Data of the HELENA-Trial (Healthy nutrition and energy restriction as cancer prevention strategies: a randomized controlled intervention trial), a randomized controlled trial (RCT) among 137 non-smoking, overweight or obese participants, were analysed to quantify the Magnetic Resonance Imaging (MRI)-derived BMFC at baseline, after a 12-week dietary intervention phase, and after a 50-week follow-up. The study cohort was classified into quartiles based on changes in body weight between baseline and week 12. Changes in BMFC in respect of weight loss were analysed by linear mixed models. Spearman\u2019s coefficients were used to assess correlations between anthropometric parameters, blood biochemical markers, blood cells and BMFC. Results: Relative changes in BMFC from baseline to week 12 were 0.0 \u00b1 0.2%, \u22123.2 \u00b1 0.1%, \u22126.1 \u00b1 0.2% and \u221211.5 \u00b1 0.6% for Q1 to Q4. Across all four quartiles and for the two-group comparison, Q1 versus Q4, there was a significant difference (p &lt; 0.05) for changes in BMFC. BMFC was not associated with blood cell counts and showed only weaker correlations (&lt;0.3) with metabolic biomarkers. Conclusion: Weight loss is associated with a decrease of BMFC. However, BMFC showed no stronger associations with inflammatory and metabolic biomarkers.<\/jats:p>","DOI":"10.3390\/nu12051509","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T10:18:18Z","timestamp":1590142698000},"page":"1509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss"],"prefix":"10.3390","volume":"12","author":[{"given":"Manuela","family":"Spurny","sequence":"first","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon A.","family":"Sowah","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Sch\u00fcbel","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"},{"name":"German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Nonnenmacher","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bertheau","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy","family":"Kirsten","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theron","family":"Johnson","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1778-0010","authenticated-orcid":false,"given":"Jens","family":"Hillengass","sequence":"additional","affiliation":[{"name":"Roswell Park Comprehensive Cancer Center, Elm &amp; Carlton Streets, Buffalo, New York 14263, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-1481","authenticated-orcid":false,"given":"Christopher L.","family":"Schlett","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Stra\u00dfe 55, D-79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyunbileg","family":"von Stackelberg","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Ulrich","family":"Kauczor","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Nattenm\u00fcller","sequence":"additional","affiliation":[{"name":"Heidelberg University Hospital, Diagnostic and Interventional Radiology, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"Body fatness and cancer-viewpoint of the IARC working group","volume":"375","author":"Scoccianti","year":"2016","journal-title":"New Engl. 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