{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:16:54Z","timestamp":1789431414832,"version":"build-2803163510"},"reference-count":91,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo - FAPESP","award":["10\/52180-4"],"award-info":[{"award-number":["10\/52180-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model known to induce renal damage in order to evaluate whether soy isoflavones could have promising use in the treatment of renal alterations. After two months of ingestion, there was an expansion of visceral fat, which was associated with long-term metabolic disorders, such as sustained hyperglycemia, insulin resistance, polyuria, dyslipidemia, and hypertension. Additionally, we found a decrease in renal blood flow and an increase in renal vascular resistance. Biochemical markers of chronic kidney disease were detected; there was an infiltration of inflammatory cells with an elevated expression of proinflammatory cytokines (tumor necrosis factor-\u03b1, interleukin (IL)-6, and IL-1\u03b2), the activation of the renin\u2013angiotensin system, and oxidative\/nitrosative stress. Notably, in rats exposed to the DH diet for 120 days, the concomitant treatment with isoflavones after 60 days was able to revert metabolic parameters, renal alterations, and oxidative\/nitrosative stress. The beneficial effects of isoflavones in the kidney of the obese rats were found to be mediated by expression of peroxisome proliferator-activated receptor gamma (PPAR-\u03b3).<\/jats:p>","DOI":"10.3390\/nu12061624","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:09:03Z","timestamp":1591070943000},"page":"1624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Beneficial Effects of Isoflavones in the Kidney of Obese Rats Are Mediated by PPAR-Gamma Expression"],"prefix":"10.3390","volume":"12","author":[{"given":"Edson de Andrade","family":"Pessoa","sequence":"first","affiliation":[{"name":"Nephrology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04023-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9921-9106","authenticated-orcid":false,"given":"M\u00e1rcia Bastos","family":"Convento","sequence":"additional","affiliation":[{"name":"Nephrology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04023-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Castino","sequence":"additional","affiliation":[{"name":"Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, S\u00e3o Paulo SP 01506-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala Moana","family":"Leme","sequence":"additional","affiliation":[{"name":"Nephrology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04023-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia Silva","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Nephrology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04023-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alef","family":"Arag\u00e3o","sequence":"additional","affiliation":[{"name":"Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, S\u00e3o Paulo SP 01506-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila Marques","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Experimentation Laboratory in Animal Model, School of Nursing, Universidade de S\u00e3o Paulo, S\u00e3o Paulo SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8129-0318","authenticated-orcid":false,"given":"Adriana","family":"Carbonel","sequence":"additional","affiliation":[{"name":"Histology and Structural Biology Division, Department of Morphology and Genetics, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04039-032, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassiane","family":"Dezoti","sequence":"additional","affiliation":[{"name":"Experimentation Laboratory in Animal Model, School of Nursing, Universidade de S\u00e3o Paulo, S\u00e3o Paulo SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de F\u00e1tima","family":"Vattimo","sequence":"additional","affiliation":[{"name":"Department Medical-Surgical Nursing, School of Nursing, Universidade de S\u00e3o Paulo, S\u00e3o Paulo SP 05403-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor","family":"Schor","sequence":"additional","affiliation":[{"name":"Nephrology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04023-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-0915","authenticated-orcid":false,"given":"Fernanda Teixeira","family":"Borges","sequence":"additional","affiliation":[{"name":"Nephrology Division, Department of Medicine, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo SP 04023-900, Brazil"},{"name":"Interdisciplinary Postgraduate Program in Health Sciences, Universidade Cruzeiro do Sul, S\u00e3o Paulo SP 01506-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/epirev\/mxm011","article-title":"The Real Contribution of Added Sugars and Fats to Obesity","volume":"29","author":"Drewnowski","year":"2007","journal-title":"Epidemiol. 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