{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T14:01:44Z","timestamp":1777816904719,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["SAF 2016-76648-R"],"award-info":[{"award-number":["SAF 2016-76648-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"name":"People Programme of the EU\u2019s 7th Framework","award":["607652 ITN NeuroGut"],"award-info":[{"award-number":["607652 ITN NeuroGut"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK048351 (EAM) and U54DK123755-01"],"award-info":[{"award-number":["R01 DK048351 (EAM) and U54DK123755-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The neural mechanisms underlying subjective responses to meal ingestion remain incompletely understood. We previously showed in healthy men an increase in thalamocortical, and a decrease in insular-cortical connectivity in response to a palatable meal. As sex is increasingly recognized as an important biological variable, we aimed to evaluate sex differences and commonalities in the impact of a well-liked meal on thalamic and anterior insular connectivity in healthy individuals. Participants (20 women and 20 age-matched men) underwent resting-state magnetic resonance imaging (rsMRI) before and after ingesting a palatable meal. In general, the insula showed extensive postprandial reductions in connectivity with sensorimotor and prefrontal cortices, while the thalamus showed increases in connectivity with insular, frontal, and occipital cortices, in both women and men. However, reductions in insular connectivity were more prominent in men, and were related to changes in meal-related sensations (satiety and digestive well-being) in men only. In contrast, increases in thalamic connectivity were more prominent in women, and were related to changes in satiety and digestive well-being in women only. These results suggest that brain imaging may provide objective and sex-specific biomarkers of the subjective feelings associated with meal ingestion.<\/jats:p>","DOI":"10.3390\/nu12061627","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T04:09:03Z","timestamp":1591070943000},"page":"1627","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Sex Differences and Commonalities in the Impact of a Palatable Meal on Thalamic and Insular Connectivity"],"prefix":"10.3390","volume":"12","author":[{"given":"Lisa","family":"Kilpatrick","sequence":"first","affiliation":[{"name":"Division of Digestive Diseases, G Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-7757","authenticated-orcid":false,"given":"Teodora","family":"Pribic","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit, University Hospital Vall d\u2019Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Ciccantelli","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit, University Hospital Vall d\u2019Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7097-1492","authenticated-orcid":false,"given":"Carolina","family":"Malagelada","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit, University Hospital Vall d\u2019Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-9638","authenticated-orcid":false,"given":"Dan M.","family":"Livovsky","sequence":"additional","affiliation":[{"name":"Digestive Diseases Institute, Shaare Zedek Medical Center, Hebrew University, 9103102 Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Accarino","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit, University Hospital Vall d\u2019Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Pareto","sequence":"additional","affiliation":[{"name":"Radiology Department, University Hospital Vall d\u2019Hebron, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-960X","authenticated-orcid":false,"given":"Fernando","family":"Azpiroz","sequence":"additional","affiliation":[{"name":"Digestive System Research Unit, University Hospital Vall d\u2019Hebron, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (Ciberehd), Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra (Cerdanyola del Vall\u00e8s), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Division of Digestive Diseases, G Oppenheimer Center for Neurobiology of Stress and Resilience, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Livovsky, D.M., Pribic, T., and Azpiroz, F. 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