{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:35:38Z","timestamp":1762508138498,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>To date, there are no recommendations about screening plasma vitamin C concentration and adjust its supplementation in patients on long-term home parenteral nutrition (HPN). The aim of this study was to evaluate vitamin C status and determine if a commercial multivitamin preparation (CMVP) containing 125 mg of vitamin C is sufficient in stable patients on HPN. All clinically stable patients receiving HPN or an intravenous fluid infusion at least two times per week for at least 6 months, hospitalized for nutritional assessment, were retrospectively included, for a total of 186 patients. We found that 29% of the patients had vitamin C insufficiency (i.e., &lt;25 \u00b5mol\/L). In univariate analysis, C-reactive protein (CRP) (p = 0.002) and intake of only 125 mg of vitamin C (p = 0.001) were negatively associated with vitamin C levels, and duration of follow-up in our referral center (p = 0.009) was positively associated with vitamin C levels. In multivariate analysis, only CRP (p = 0.001) and intake of 125 mg of vitamin C (p &lt; 0.0001) were independently associated with low plasma vitamin C concentration. Patients receiving only CMVP with a low plasma vitamin C level significantly received personal compounded HPN (p = 0.008) and presented an inflammatory syndrome (p = 0.002). Vitamin C insufficiency is frequent in individuals undergoing home parenteral nutrition; therefore, there is a need to monitor plasma vitamin C levels, especially in patients on HPN with an inflammatory syndrome and only on CMVP.<\/jats:p>","DOI":"10.3390\/nu12061667","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T04:36:09Z","timestamp":1591245369000},"page":"1667","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin C in Home Parenteral Nutrition: A Need for Monitoring"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-5382","authenticated-orcid":false,"given":"Julienne","family":"Grillot","sequence":"first","affiliation":[{"name":"Nutrition Intensive Care Unit, Hospices Civil de Lyon, CEDEX, F-69495 Pierre Benite, France"},{"name":"CarMeN Laboratory, INSERM, INRA, INSA Lyon, Universit\u00e9 Claude Bernard Lyon 1, CEDEX, 69921 Oullins, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Ait","sequence":"additional","affiliation":[{"name":"Nutrition Intensive Care Unit, Hospices Civil de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Bergoin","sequence":"additional","affiliation":[{"name":"Nutrition Intensive Care Unit, Hospices Civil de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Couronne","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospices Civils de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilie","family":"Blond","sequence":"additional","affiliation":[{"name":"CarMeN Laboratory, INSERM, INRA, INSA Lyon, Universit\u00e9 Claude Bernard Lyon 1, CEDEX, 69921 Oullins, France"},{"name":"Biochemistry Department, Lyon Sud Hospital, Hospices Civils de Lyon, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Peraldi","sequence":"additional","affiliation":[{"name":"Centre Agr\u00e9\u00e9 de Nutrition Parent\u00e9rale \u00e0 Domicile, Hospices Civils de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Barnoud","sequence":"additional","affiliation":[{"name":"Nutrition Intensive Care Unit, Hospices Civil de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Chambrier","sequence":"additional","affiliation":[{"name":"Nutrition Intensive Care Unit, Hospices Civil de Lyon, CEDEX, F-69495 Pierre Benite, France"},{"name":"Centre Agr\u00e9\u00e9 de Nutrition Parent\u00e9rale \u00e0 Domicile, Hospices Civils de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Lauverjat","sequence":"additional","affiliation":[{"name":"Centre Agr\u00e9\u00e9 de Nutrition Parent\u00e9rale \u00e0 Domicile, Hospices Civils de Lyon, CEDEX, F-69495 Pierre Benite, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.clnu.2009.04.001","article-title":"ESPEN Guidelines on Parenteral Nutrition: Home Parenteral Nutrition (HPN) in adult patients","volume":"28","author":"Staun","year":"2009","journal-title":"Clin. Nutr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/odi.12446","article-title":"Vitamin C: The known and the unknown and Goldilocks","volume":"22","author":"Padayatty","year":"2016","journal-title":"Oral Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1053\/j.gastro.2009.08.012","article-title":"Vitamin C requirements in parenteral nutrition","volume":"137","author":"Berger","year":"2009","journal-title":"Gastroenterology"},{"key":"ref_4","unstructured":"Haute Autorit\u00e9 de Sant\u00e9 (2020, May 28). Dosage de la Vitamine C Dans le Sang. Available online: https:\/\/www.has-sante.fr\/jcms\/c_2823990\/fr\/dosage-de-la-vitamine-c-dans-le-sang."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.nut.2004.04.001","article-title":"Vitamin and mineral status: Effects on physical performance","volume":"20","author":"Lukaski","year":"2004","journal-title":"Nutrition"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/0884533612446706","article-title":"A.S.P.E.N. Position Paper: Recommendations for changes in commercially available parenteral multivitamin and multi-trace element products","volume":"27","author":"Vanek","year":"2012","journal-title":"Nutr. Clin. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.nut.2008.06.004","article-title":"AuSPEN clinical practice guideline for home parenteral nutrition patients in Australia and New Zealand","volume":"24","author":"Gillanders","year":"2008","journal-title":"Nutrition"},{"key":"ref_8","first-page":"305","article-title":"Plasma Ascorbic Acid: Preanalytical Factors and New HPLC Method","volume":"62","author":"Steghens","year":"2004","journal-title":"Ann. Biol. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1177\/0004563214542471","article-title":"Overview of the in vitro stability of commonly measured vitamins and carotenoids in whole blood","volume":"52","author":"Cuerq","year":"2015","journal-title":"Ann. Clin. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0148607188012002205","article-title":"Plasma vitamin levels in patients on prolonged total parenteral nutrition","volume":"12","author":"Labadarios","year":"1988","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/0148607110386964","article-title":"Serum vitamins in adult patients with short bowel syndrome receiving intermittent parenteral nutrition","volume":"35","author":"Braga","year":"2011","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10715760310001636346","article-title":"4-Hydroxynonenal is markedly higher in patients on a standard long-term home parenteral nutrition","volume":"38","author":"Massarenti","year":"2004","journal-title":"Free Radic. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3747\/co.25.3790","article-title":"Intravenous vitamin C in the supportive care of cancer patients: A review and rational approach","volume":"25","author":"Klimant","year":"2018","journal-title":"Curr. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1191\/0269216305pm970oa","article-title":"Vitamin C deficiency in cancer patients","volume":"19","author":"Mayland","year":"2005","journal-title":"Palliat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2710.1995.tb00660.x","article-title":"Serum beta-carotene, vitamin E, vitamin C and malondialdehyde levels in several types of cancer","volume":"20","author":"Torun","year":"1995","journal-title":"J. Clin. Pharm. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-008-8309-2","article-title":"Evaluation of Oxidative Stress, Antioxidant Status and Serum Vitamin C Levels in Cancer Patients","volume":"130","author":"Mahdavi","year":"2009","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/clpt.2009.254","article-title":"Inflammation and Cancer: Causes and Consequences","volume":"87","author":"Moore","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/ajcn\/21.11.1259","article-title":"Smoking and vitamin C levels in humans","volume":"21","author":"Pelletier","year":"1968","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.2105\/AJPH.79.2.158","article-title":"The influence of smoking on vitamin C status in adults","volume":"79","author":"Schectman","year":"1989","journal-title":"Am. J. Public Health"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/ajcn\/53.6.1466","article-title":"Ascorbic acid requirements for smokers: Analysis of a population survey","volume":"53","author":"Schectman","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.nut.2006.06.004","article-title":"Vitamins and trace elements: Practical aspects of supplementation","volume":"22","author":"Berger","year":"2006","journal-title":"Nutrition"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/0148607102026005310","article-title":"Physical characteristics of total parenteral nutrition bags significantly affect the stability of vitamins C and B1: A controlled prospective study","volume":"26","author":"Dupertuis","year":"2002","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0261-5614(94)90049-3","article-title":"Stability of ascorbic acid in a standard total parenteral nutrition mixture","volume":"13","author":"Proot","year":"1994","journal-title":"Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0261-5614(92)90005-B","article-title":"The stability of ascorbic acid in TPN mixtures stored in a multilayered bag","volume":"11","author":"Allwood","year":"1992","journal-title":"Clin. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0022-3476(97)80058-3","article-title":"Influence of bacterial overgrowth and intestinal inflammation on duration of parenteral nutrition in children with short bowel syndrome","volume":"131","author":"Kaufman","year":"1997","journal-title":"J. Pediatr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cgh.2005.10.020","article-title":"Enteric Microbial Flora, Bacterial Overgrowth, and Short-Bowel Syndrome","volume":"4","author":"DiBaise","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Devine, A.A., Gonz\u00e1lez, A., Speck, K.E., Knight, R., Helmrath, M., Lund, P.K., and Azcarate-Peril, M.A. (2013). Impact of Ileocecal Resection and Concomitant Antibiotics on the Microbiome of the Murine Jejunum and Colon. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0073140"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4161\/gmic.24372","article-title":"Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome","volume":"4","author":"Lapthorne","year":"2013","journal-title":"Gut Microbes"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Schall, K.A., Thornton, M., Isani, M., Holoyda, K.A., Hou, X., Lien, C.-L., Grubbs, B.H., and Grikscheit, T.C. (2017). Short bowel syndrome results in increased gene expression associated with proliferation, inflammation, bile acid synthesis and immune system activation: RNA sequencing a zebrafish SBS model. BMC Genom., 18.","DOI":"10.1186\/s12864-016-3433-4"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.biochi.2010.02.015","article-title":"Drastic changes in fecal and mucosa-associated microbiota in adult patients with short bowel syndrome","volume":"92","author":"Joly","year":"2010","journal-title":"Biochimie"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fphys.2017.00224","article-title":"Microbiota Is Involved in Post-resection Adaptation in Humans with Short Bowel Syndrome","volume":"8","author":"Gillard","year":"2017","journal-title":"Front. Physiol."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1667\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:35:25Z","timestamp":1760175325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,3]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["nu12061667"],"URL":"https:\/\/doi.org\/10.3390\/nu12061667","relation":{},"ISSN":["2072-6643"],"issn-type":[{"type":"electronic","value":"2072-6643"}],"subject":[],"published":{"date-parts":[[2020,6,3]]}}}