{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:52:47Z","timestamp":1790473967315,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Dietary advanced glycation end products (AGEs) are believed to contribute to pathogenesis of diabetes and cardiovascular disease. The objective of this study was to determine if a diet high in red and processed meat and refined grains (HMD) would elevate plasma concentrations of protein-bound AGEs compared with an energy-matched diet high in whole grain, dairy, nuts and legumes (HWD). We conducted a randomized crossover trial with two 4-week weight-stable dietary interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 \u00b1 15.6 y; body mass index (BMI), 27.7 \u00b1 6.9 kg\/m2). Plasma concentrations of protein-bound N\u03b5-(carboxymethyl) lysine (CML), N\u03b5-(1-carboxyethyl) lysine (CEL) and N\u03b4-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured by liquid chromatography\u2013tandem mass spectrometry (LC-MS\/MS). The HMD significantly increased plasma concentrations (nmol\/mL) of CEL (1.367, 0.78 vs. 1.096, 0.65; p &lt; 0.01; n = 48) compared with the HWD. No differences in CML and MG-H1 between HMD and HWD were observed. HMD increased plasma CEL concentrations compared with HWD in individuals without type 2 diabetes.<\/jats:p>","DOI":"10.3390\/nu12061767","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T03:17:32Z","timestamp":1592191052000},"page":"1767","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Yoona","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4788-3870","authenticated-orcid":false,"given":"Jennifer B.","family":"Keogh","sequence":"additional","affiliation":[{"name":"Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-9127","authenticated-orcid":false,"given":"Permal","family":"Deo","sequence":"additional","affiliation":[{"name":"Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-626X","authenticated-orcid":false,"given":"Peter M.","family":"Clifton","sequence":"additional","affiliation":[{"name":"Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide SA 5000, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/nure.12141","article-title":"Effect of advanced glycation end product intake on inflammation and aging: A systematic review","volume":"72","author":"Mets","year":"2014","journal-title":"Nutr. 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