{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T08:16:29Z","timestamp":1791965789644,"version":"4.3.4"},"reference-count":131,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["W1241"],"award-info":[{"award-number":["W1241"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>The human skin hosts innumerable microorganisms and maintains homeostasis with the local immune system despite the challenges offered by environmental factors such as ultraviolet radiation (UVR). UVR causes cutaneous alterations such as acute (i.e., sunburn) and chronic inflammation, tanning, photoaging, skin cancer, and immune modulation. Phototherapy on the other hand is widely used to treat inflammatory skin diseases such as psoriasis, atopic dermatitis, polymorphic light eruption and graft-versus-host disease (GvHD), as well as neoplastic skin diseases such as cutaneous T cell lymphoma, among others. Previous work has addressed the use of pro- and pre-biotics to protect against UVR through anti-oxidative, anti-inflammatory, anti-aging, anti-carcinogenic and\/or pro-and contra-melanogenic properties. Herein, we discuss and share perspectives of the potential benefits of novel treatment strategies using microbes and pro- and pre-biotics as modulators of the skin response to UVR, and how they could act both for protection against UVR-induced skin damage and as enhancers of the UVR-driven therapeutic effects on the skin.<\/jats:p>","DOI":"10.3390\/nu12061795","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T13:11:32Z","timestamp":1592399492000},"page":"1795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Potential of Skin Microbiome, Pro- and\/or Pre-Biotics to Affect Local Cutaneous Responses to UV Exposure"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-7767","authenticated-orcid":false,"given":"VijayKumar","family":"Patra","sequence":"first","affiliation":[{"name":"Center for Medical Research, Medical University of Graz, 8010 Graz, Austria"},{"name":"Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e8ne","family":"Gallais S\u00e9r\u00e9zal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Rheumatology, Karolinska Institutet, 171 77 Solna, Sweden"},{"name":"Department of Dermatology, Besan\u00e7on University Hospital, 25000 Besancon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-9444","authenticated-orcid":false,"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Research Unit for Photodermatology, Department of Dermatology, Medical University of Graz, 8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1101\/gr.075549.107","article-title":"A diversity profile of the human skin microbiota","volume":"18","author":"Grice","year":"2008","journal-title":"Genome Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nm.4517","article-title":"Current understanding of the human microbiome","volume":"24","author":"Gilbert","year":"2018","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Probst, A.J., Auerbach, A.K., and Moissl-Eichinger, C. (2013). Archaea on human skin. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065388"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000323009","article-title":"Demodex mites--commensals, parasites or mutualistic organisms?","volume":"222","author":"Lacey","year":"2011","journal-title":"Dermatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat. Rev. Microbiol.."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1128\/JCM.00597-10","article-title":"Quantitation of major human cutaneous bacterial and fungal populations","volume":"48","author":"Gao","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/nature14052","article-title":"Commensal-dendritic-cell interaction specifies a unique protective skin immune signature","volume":"520","author":"Naik","year":"2015","journal-title":"Nature"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40168-018-0404-9","article-title":"Commensal microbiota modulate gene expression in the skin","volume":"6","author":"Meisel","year":"2018","journal-title":"Microbiome"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.isci.2019.04.026","article-title":"Skin Microbiome Modulates the Effect of Ultraviolet Radiation on Cellular Response and Immune Function","volume":"15","author":"Patra","year":"2019","journal-title":"iScience"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000051543","article-title":"UV transmission measurements of small skin specimens with special quartz cuvettes","volume":"201","author":"Hoffmann","year":"2000","journal-title":"Dermatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-2836(66)80105-5","article-title":"Pyrimidine dimers in ultraviolet-irradiated DNA\u2019s","volume":"17","author":"Setlow","year":"1966","journal-title":"J. Mol. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/j.1751-1097.1989.tb05578.x","article-title":"The biology of the (6\u20134) photoproduct","volume":"49","author":"Mitchell","year":"1989","journal-title":"Photochem. Photobiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1751-1097.1982.tb02628.x","article-title":"Single-strand breaks induced in Bacillus subtilis DNA by ultraviolet light: Action spectrum and properties","volume":"35","author":"Peak","year":"1982","journal-title":"Photochem. Photobiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1751-1097.1984.tb05349.x","article-title":"Ultraviolet action spectra for DNA dimer induction, lethality, and mutagenesis in Escherichia coli with emphasis on the UVB region","volume":"40","author":"Peak","year":"1984","journal-title":"Photochem. Photobiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1011-1344(01)00269-X","article-title":"The role of UV-B radiation in aquatic and terrestrial ecosystems--an experimental and functional analysis of the evolution of UV-absorbing compounds","volume":"66","author":"Rozema","year":"2002","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_17","first-page":"171","article-title":"Quantitation of pyrimidine dimers in DNA from UVB-irradiated alfalfa (Medicago sativa L.) seedlings","volume":"2","author":"Quaite","year":"1992","journal-title":"Appl. Theor. Electrophor."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1039\/b201230h","article-title":"UV-induced DNA damage and repair: A review","volume":"1","author":"Sinha","year":"2002","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ejsobi.2009.04.003","article-title":"Ultraviolet-B exposure induces photo-oxidative damage and subsequent repair strategies in a desert cyanobacterium Microcoleus vaginatus Gom","volume":"45","author":"Xie","year":"2009","journal-title":"Eur. J. Soil Boil."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1562\/2005-02-15-IR-441","article-title":"UVR, vitamin D and three autoimmune diseases--multiple sclerosis, type 1 diabetes, rheumatoid arthritis","volume":"81","author":"Ponsonby","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1562\/2005-01-24-RA-424","article-title":"Comparisons of estimated economic burdens due to insufficient solar ultraviolet irradiance and vitamin D and excess solar UV irradiance for the United States","volume":"81","author":"Grant","year":"2005","journal-title":"Photochem. Photobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrcardio.2009.135","article-title":"Vitamin D status and arterial hypertension: A systematic review","volume":"6","author":"Pilz","year":"2009","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nri2047","article-title":"Vitamin D3 promotes immune function in the skin","volume":"7","author":"Bell","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response","volume":"311","author":"Liu","year":"2006","journal-title":"Science"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ni1433","article-title":"DCs metabolize sunlight-induced vitamin D3 to \u2019program\u2019 T cell attraction to the epidermal chemokine CCL27","volume":"8","author":"Sigmundsdottir","year":"2007","journal-title":"Nat. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI30142","article-title":"Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism","volume":"117","author":"Schauber","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.4049\/jimmunol.1400232","article-title":"Systemic response to ultraviolet radiation involves induction of leukocytic IL-1beta and inflammation in zebrafish","volume":"193","author":"Banerjee","year":"2014","journal-title":"J. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.33176\/AACB-19-00026","article-title":"Systematic Review of the Effects of Ultraviolet Radiation on Markers of Metabolic Dysfunction","volume":"40","author":"Gorman","year":"2019","journal-title":"Clin. Biochem. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1210\/en.2017-03230","article-title":"How UV Light Touches the Brain and Endocrine System Through Skin, and Why","volume":"159","author":"Slominski","year":"2018","journal-title":"Endocrinology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fmed.2020.00330","article-title":"Quality of life, anxiety and depression in patients with early-stage mycosis fungoides and the effect of oral psoralen plus UV-A (PUVA) photochemotherapy on it","volume":"7","author":"Graier","year":"2020","journal-title":"Front. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/jid.2015.56","article-title":"Skin under the (Spot)-Light: Cross-Talk with the Central Hypothalamic-Pituitary-Adrenal (HPA) Axis","volume":"135","author":"Jozic","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.cell.2014.04.032","article-title":"Skin beta-endorphin mediates addiction to UV light","volume":"157","author":"Fell","year":"2014","journal-title":"Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.cell.2014.06.009","article-title":"Shedding \"UV\" light on endogenous opioid dependence","volume":"157","author":"Tejeda","year":"2014","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/exd.13021","article-title":"Opioids and skin homeostasis, regeneration and ageing\u2014What\u2019s the evidence?","volume":"25","author":"Bigliardi","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1039\/c6pp00337k","article-title":"Serum endocannabinoids and N-acyl ethanolamines and the influence of simulated solar UVR exposure in humans in vivo","volume":"16","author":"Felton","year":"2017","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.3389\/fmicb.2019.02410","article-title":"Skin Exposure to Narrow Band Ultraviolet (UVB) Light Modulates the Human Intestinal Microbiome","volume":"10","author":"Bosman","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41577-019-0185-9","article-title":"Photoimmunology: How ultraviolet radiation affects the immune system","volume":"19","author":"Bernard","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.det.2019.08.004","article-title":"How It Works: The Immunology Underlying Phototherapy","volume":"38","author":"Yu","year":"2020","journal-title":"Dermatol. Clin."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fmed.2018.00232","article-title":"From Early Immunomodulatory Triggers to Immunosuppressive Outcome: Therapeutic Implications of the Complex Interplay Between the Wavebands of Sunlight and the Skin","volume":"5","author":"Wolf","year":"2018","journal-title":"Front. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1751-1097.2007.00226.x","article-title":"The protective role of melanin against UV damage in human skin","volume":"84","author":"Brenner","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"28052","DOI":"10.1074\/jbc.271.45.28052","article-title":"Ultraviolet B radiation acts through the nitric oxide and cGMP signal transduction pathway to stimulate melanogenesis in human melanocytes","volume":"271","author":"Aberdam","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1016\/0303-7207(94)90001-9","article-title":"Towards defining receptors for L-tyrosine and L-dopa","volume":"99","author":"Slominski","year":"1994","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","article-title":"Melanin pigmentation in mammalian skin and its hormonal regulation","volume":"84","author":"Slominski","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0022-5193(05)80292-9","article-title":"Are L-tyrosine and L-dopa hormone-like bioregulators?","volume":"143","author":"Slominski","year":"1990","journal-title":"J. Theor. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaad.2005.05.022","article-title":"Skin cancer in African Americans","volume":"53","author":"Heymann","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/1097-0142(19950115)75:2+<667::AID-CNCR2820751409>3.0.CO;2-I","article-title":"Skin cancer in African Americans","volume":"75","author":"Halder","year":"1995","journal-title":"Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1039\/c4pp00013g","article-title":"Analysis of UV-absorbing photoprotectant mycosporine-like amino acid (MAA) in the cyanobacterium Arthrospira sp. CU2556","volume":"13","author":"Rastogi","year":"2014","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"42129","DOI":"10.1038\/srep42129","article-title":"Bioproduction, characterization, anticancer and antioxidant activities of extracellular melanin pigment produced by newly isolated microbial cell factories Streptomyces glaucescens NEAE-H","volume":"7","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1002\/jobm.201900295","article-title":"Production of melanin pigments in saprophytic fungi in vitro and during infection","volume":"59","author":"Chongkae","year":"2019","journal-title":"J. Basic Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1099\/mic.0.047928-0","article-title":"Melanogenesis in dermatophyte species in vitro and during infection","volume":"157","author":"Youngchim","year":"2011","journal-title":"Microbiology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3314\/jjmm.46.169","article-title":"Examination of the causative agent of pityriasis versicolor","volume":"46","author":"Morishita","year":"2005","journal-title":"Nihon. Ishinkin Gakkai Zasshi"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12171","article-title":"Topographic diversity of fungal and bacterial communities in human skin","volume":"498","author":"Findley","year":"2013","journal-title":"Nature"},{"key":"ref_53","first-page":"449","article-title":"Effect of gamma and UV irradiation on the survival of Cladosporium sp. and Oidiodendron cerealis","volume":"35","author":"Zhdanova","year":"1973","journal-title":"Mikrobiol. Zhurnal"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1128\/IAI.68.6.3696-3703.2000","article-title":"Biosynthesis and functions of melanin in Sporothrix schenckii","volume":"68","author":"Wheeler","year":"2000","journal-title":"Infect. Immun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.1128\/aem.60.10.3864-3866.1994","article-title":"Decreased susceptibility of melanized Cryptococcus neoformans to UV light","volume":"60","author":"Wang","year":"1994","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1365-2133.2011.10490.x","article-title":"Serotonin induces melanogenesis via serotonin receptor 2A","volume":"165","author":"Lee","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3389\/fbioe.2019.00285","article-title":"Production of Melanins With Recombinant Microorganisms","volume":"7","author":"Martinez","year":"2019","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1078\/0723-2020-00265","article-title":"Melanin pigment formation and increased UV resistance in Bacillus thuringiensis following high temperature induction","volume":"27","author":"Ruan","year":"2004","journal-title":"Syst. Appl. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1574-6968.2009.01716.x","article-title":"Characterization of melanin-overproducing transposon mutants of Pseudomonas putida F6","volume":"298","author":"Martin","year":"2009","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Peyrat, L.A., Tsafantakis, N., Georgousaki, K., Ouazzani, J., Genilloud, O., Trougakos, I.P., and Fokialakis, N. (2019). Terrestrial Microorganisms: Cell Factories of Bioactive Molecules with Skin Protecting Applications. Molecules, 24.","DOI":"10.3390\/molecules24091836"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00403-002-0294-2","article-title":"Pityriacitrin\u2014An ultraviolet-absorbing indole alkaloid from the yeast Malassezia furfur","volume":"294","author":"Mayser","year":"2002","journal-title":"Arch. Dermatol. Res."},{"key":"ref_63","first-page":"265","article-title":"The genus Malassezia and human disease","volume":"69","author":"Inamadar","year":"2003","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_64","first-page":"32","article-title":"Resurvey of symptomatics of the Jaipur district population and suggestion for alternative diagnostic criteria of asthma for epidemiological surveys","volume":"1","author":"Gupta","year":"2014","journal-title":"Pigment. Int."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/jam.13506","article-title":"Skin resistance to UVB-induced oxidative stress and hyperpigmentation by the topical use of Lactobacillus helveticus NS8-fermented milk supernatant","volume":"123","author":"Rong","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Bocheva, G., Slominski, R.M., and Slominski, A.T. (2019). Neuroendocrine Aspects of Skin Aging. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20112798"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejca.2007.09.009","article-title":"The effect of solar UVB doses and vitamin D production, skin cancer action spectra, and smoking in explaining links between skin cancers and solid tumours","volume":"44","author":"Grant","year":"2008","journal-title":"Eur. J. Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1755-148X.2011.00946.x","article-title":"Site-dependent actinic skin damage as risk factor for melanoma in a central European population","volume":"25","author":"Wendt","year":"2012","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3390\/ijms16010068","article-title":"Exposure to non-extreme solar UV daylight: Spectral characterization, effects on skin and photoprotection","volume":"16","author":"Marionnet","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_70","first-page":"457","article-title":"Neuroendocrinology of the skin","volume":"21","author":"Slominski","year":"2000","journal-title":"Endocr. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Slominski, A.T., Zmijewski, M.A., Skobowiat, C., Zbytek, B., Slominski, R.M., and Steketee, J.D. (2012). Introduction. Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin\u2019s Neuroendocrine System, Springer.","DOI":"10.1007\/978-3-642-19683-6"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6202","DOI":"10.3390\/molecules19056202","article-title":"Ultraviolet radiation, aging and the skin: Prevention of damage by topical cAMP manipulation","volume":"19","author":"Yan","year":"2014","journal-title":"Molecules"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"10567","DOI":"10.1038\/s41598-017-10834-9","article-title":"Aging-related changes in the diversity of women\u2019s skin microbiomes associated with oral bacteria","volume":"7","author":"Shibagaki","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/exd.13854","article-title":"Ultraviolet radiation, both UVA and UVB, influences the composition of the skin microbiome","volume":"28","author":"Burns","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Ghaly, S., Kaakoush, N.O., Lloyd, F., Gordon, L., Forest, C., Lawrance, I.C., and Hart, P.H. (2018). Ultraviolet Irradiation of Skin Alters the Faecal Microbiome Independently of Vitamin D in Mice. Nutrients, 10.","DOI":"10.3390\/nu10081069"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13311-017-0600-5","article-title":"Gut Microbiota and the Neuroendocrine System","volume":"15","author":"Farzi","year":"2018","journal-title":"Neurotherapeutics"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4161\/derm.1.5.9849","article-title":"Probiotics for photoprotection","volume":"1","author":"Gueniche","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.4014\/jmb.1406.06038","article-title":"Oral administration of Lactobacillus plantarum HY7714 protects hairless mouse against ultraviolet B-induced photoaging","volume":"24","author":"Kim","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Farage, M.A., Miller, K.W., and Maibach, H.I. (2010). The Potential of Probiotics and Prebiotics for Skin Health. Textbook of Aging Skin, Springer.","DOI":"10.1007\/978-3-540-89656-2"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijwd.2015.02.001","article-title":"The effect of probiotics on immune regulation, acne, and photoaging","volume":"1","author":"Kober","year":"2015","journal-title":"Int. J. Womens Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"923","DOI":"10.3109\/09637486.2015.1088823","article-title":"Photoprotective effects of galacto-oligosaccharide and\/or Bifidobacterium longum supplementation against skin damage induced by ultraviolet irradiation in hairless mice","volume":"66","author":"Hong","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.clindermatol.2013.01.009","article-title":"Role of infectious agents in cutaneous T-cell lymphoma: Facts and controversies","volume":"31","author":"Mirvish","year":"2013","journal-title":"Clin. Dermatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jaad.2008.08.030","article-title":"Cutaneous T-cell lymphoma and Staphylococcus aureus colonization","volume":"59","author":"Nguyen","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"eaam6346","DOI":"10.1126\/sciimmunol.aam6346","article-title":"Resident memory T cells in the skin mediate durable immunity to melanoma","volume":"2","author":"Malik","year":"2017","journal-title":"Sci. Immunol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.1225152","article-title":"Compartmentalized control of skin immunity by resident commensals","volume":"337","author":"Naik","year":"2012","journal-title":"Science"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"35S","DOI":"10.1038\/jid.1993.21","article-title":"Mechanisms of UV-induced inflammation","volume":"100","author":"Hruza","year":"1993","journal-title":"J. Investig. Dermatol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1038\/onc.2008.269","article-title":"Positive and negative influences of regulatory T cells on tumour immunity","volume":"27","author":"Gallimore","year":"2008","journal-title":"Oncogene"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"eaao4502","DOI":"10.1126\/sciadv.aao4502","article-title":"A commensal strain of Staphylococcus epidermidis protects against skin neoplasia","volume":"4","author":"Nakatsuji","year":"2018","journal-title":"Sci. Adv."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1002\/eji.201848024","article-title":"Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB-induced immunosuppression and impairs skin tumor growth in mice","volume":"49","author":"Friedrich","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Fehlbaum, S., Prudence, K., Kieboom, J., Heerikhuisen, M., van den Broek, T., Schuren, F.H.J., Steinert, R.E., and Raederstorff, D. (2018). In Vitro Fermentation of Selected Prebiotics and Their Effects on the Composition and Activity of the Adult Gut Microbiota. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19103097"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"9066","DOI":"10.1073\/pnas.1219451110","article-title":"Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity","volume":"110","author":"Everard","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jnutbio.2018.05.017","article-title":"Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat-fed male rats","volume":"59","author":"Singh","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1038\/s41467-019-09525-y","article-title":"Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5(-\/-) mice","volume":"10","author":"Li","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.celrep.2020.01.035","article-title":"Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth","volume":"30","author":"Li","year":"2020","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nrgastro.2017.20","article-title":"Gut microbiota modulation of chemotherapy efficacy and toxicity","volume":"14","author":"Alexander","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1126\/science.1240527","article-title":"Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment","volume":"342","author":"Iida","year":"2013","journal-title":"Science"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ccell.2018.03.015","article-title":"The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy","volume":"33","author":"Gopalakrishnan","year":"2018","journal-title":"Cancer Cell"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1126\/science.aan4236","article-title":"Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients","volume":"359","author":"Gopalakrishnan","year":"2018","journal-title":"Science"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Ting, S.Y., Martinez-Garcia, E., Huang, S., Bertolli, S.K., Kelly, K.A., Cutler, K.J., Su, E.D., Zhi, H., Tang, Q., and Radey, M.C. (2020). Targeted Depletion of Bacteria from Mixed Populations by Programmable Adhesion with Antagonistic Competitor Cells. Cell Host Microbe.","DOI":"10.1016\/j.chom.2020.05.006"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"ref_101","first-page":"179","article-title":"Immunologic aspects of tumor induction by ultraviolet radiation","volume":"50","author":"Kripke","year":"1978","journal-title":"Natl. Cancer Inst. Monogr."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1002\/eji.200425139","article-title":"Lactobacillus casei reduces CD8+ T cell-mediated skin inflammation","volume":"34","author":"Chapat","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Hacini-Rachinel, F., Gheit, H., Le Luduec, J.B., Dif, F., Nancey, S., and Kaiserlian, D. (2009). Oral probiotic control skin inflammation by acting on both effector and regulatory T cells. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0004903"},{"key":"ref_104","unstructured":"Jatwani, S., and Hearth Holmes, M.P. (2020). Subacute Cutaneous Lupus Erythematosus, StatPearls."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/exd.13162","article-title":"Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption?","volume":"25","author":"Patra","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.jid.2019.02.035","article-title":"Delineating the Healthy Human Skin UV Response and Early Induction of Interferon Pathway in Cutaneous Lupus Erythematosus","volume":"139","author":"Katayama","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/exd.13950","article-title":"Lactobacillus reuteri DSM 17938-A comparative study on the effect of probiotics and lysates on human skin","volume":"28","author":"Khmaladze","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.4014\/jmb.1408.08023","article-title":"Effect of oral administration of Lactobacillus plantarum HY7714 on epidermal hydration in ultraviolet B-irradiated hairless mice","volume":"24","author":"Ra","year":"2014","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/phpp.12093","article-title":"Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, beta-carotene, and Lactobacillus johnsonii: Results from a randomized, placebo-controlled, double-blinded study","volume":"30","author":"Marini","year":"2014","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jaad.2010.09.773","article-title":"Oral administration of a hydrophilic extract of Polypodium leucotomos for the prevention of polymorphic light eruption","volume":"66","author":"Tanew","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0781.2007.00274.x","article-title":"Photoprotective activity of oral polypodium leucotomos extract in 25 patients with idiopathic photodermatoses","volume":"23","author":"Caccialanza","year":"2007","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev-pathmechdis-012418-012809","article-title":"Exposure to Ultraviolet Radiation in the Modulation of Human Diseases","volume":"14","author":"Hart","year":"2019","journal-title":"Annu. Rev. Pathol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3389\/fimmu.2016.00627","article-title":"Role of Vitamin D in the Hygiene Hypothesis: The Interplay between Vitamin D, Vitamin D Receptors, Gut Microbiota, and Immune Response","volume":"7","author":"Clark","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00394-015-0966-2","article-title":"Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract","volume":"55","author":"Bashir","year":"2016","journal-title":"Eur. J. Nutr."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2133.2011.10333.x","article-title":"Randomized double-blinded placebo-controlled intra-individual trial on topical treatment with a 1,25-dihydroxyvitamin D(3) analogue in polymorphic light eruption","volume":"165","author":"Bambach","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jdermsci.2014.09.002","article-title":"Cathelicidin peptide LL-37 increases UVB-triggered inflammasome activation: Possible implications for rosacea","volume":"76","author":"Salzer","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-3083.2006.001752.x","article-title":"Antimicrobial peptide LL-37 internalized by immature human dendritic cells alters their phenotype","volume":"63","author":"Bandholtz","year":"2006","journal-title":"Scand. J. Immunol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/jid.2008.320","article-title":"Collagen synthesis is suppressed in dermal fibroblasts by the human antimicrobial peptide LL-37","volume":"129","author":"Park","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00253-013-5394-8","article-title":"Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: Implications of probiotics in acne vulgaris","volume":"98","author":"Wang","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/j.1468-3083.2007.02508.x","article-title":"Vitreoscilla filiformis biomass improves seborrheic dermatitis","volume":"22","author":"Gueniche","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/jid.2013.291","article-title":"Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells","volume":"134","author":"Volz","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/bjd.18659","article-title":"Changing our microbiome: Probiotics in dermatology","volume":"182","author":"Yu","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"eaat6280","DOI":"10.1126\/science.aat6280","article-title":"Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury","volume":"363","author":"Harrison","year":"2019","journal-title":"Science"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.4049\/jimmunol.1302313","article-title":"Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis","volume":"192","author":"Cheuk","year":"2014","journal-title":"J. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni.1718","article-title":"Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus","volume":"10","author":"Gebhardt","year":"2009","journal-title":"Nat. Immunol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e86955","DOI":"10.1172\/jci.insight.86955","article-title":"Transplantation of human skin microbiota in models of atopic dermatitis","volume":"1","author":"Myles","year":"2016","journal-title":"JCI Insight"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e120608","DOI":"10.1172\/jci.insight.120608","article-title":"First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis","volume":"3","author":"Myles","year":"2018","journal-title":"JCI Insight"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1086\/368080","article-title":"Safety of probiotics that contain lactobacilli or bifidobacteria","volume":"36","author":"Borriello","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1097\/01.mcg.0000128929.37156.a7","article-title":"Tolerance of probiotics and prebiotics","volume":"38","author":"Marteau","year":"2004","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.jaci.2013.03.020","article-title":"Microbial influence on tolerance and opportunities for intervention with prebiotics\/probiotics and bacterial lysates","volume":"131","author":"Pfefferle","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/apt.14539","article-title":"Systematic review: Probiotics in the management of lower gastrointestinal symptoms\u2014an updated evidence-based international consensus","volume":"47","author":"Hungin","year":"2018","journal-title":"Aliment. Pharmacol. Ther."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1795\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:39:45Z","timestamp":1760175585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":131,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["nu12061795"],"URL":"https:\/\/doi.org\/10.3390\/nu12061795","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]}}}