{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:47:50Z","timestamp":1788929270839,"version":"build-2803163510"},"reference-count":70,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T00:00:00Z","timestamp":1592524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>S-allylcysteine (SAC), a major thioallyl compound contained in mature garlic extract (MGE), is known to be a neuroactive compound. This study was designed to investigate the effects of SAC on primary cultured hippocampal neurons and cognitively impaired senescence-accelerated mice prone 10 (SAMP10). Treatment of these neurons with MGE or SAC significantly increased the total neurite length and number of dendrites. SAMP10 mice fed MGE or SAC showed a significant improvement in memory dysfunction in pharmacological behavioral analyses. The decrease of \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, N-methyl-d-aspartate (NMDA) receptor, and phosphorylated \u03b1-calcium\/calmodulin-dependent protein kinase II (CaMKII) in the hippocampal tissue of SAMP10 mice fed MGE or SAC was significantly suppressed, especially in the MGE-fed group. These findings suggest that SAC positively contributes to learning and memory formation, having a beneficial effect on brain function. In addition, multiple components (aside from SAC) contained in MGE could be useful for improving cognitive function by acting as neurotrophic factors.<\/jats:p>","DOI":"10.3390\/nu12061834","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T10:43:58Z","timestamp":1592563438000},"page":"1834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Improvement of Learning and Memory in Senescence-Accelerated Mice by S-Allylcysteine in Mature Garlic Extract"],"prefix":"10.3390","volume":"12","author":[{"given":"Masakazu","family":"Hashimoto","sequence":"first","affiliation":[{"name":"United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"},{"name":"Research and Development Department, Ichimaru Pharcos Co., Ltd., 318-1 Asagi, Gifu 501-0475, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Nakai","sequence":"additional","affiliation":[{"name":"Research and Development Department, Ichimaru Pharcos Co., Ltd., 318-1 Asagi, Gifu 501-0475, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruaki","family":"Masutani","sequence":"additional","affiliation":[{"name":"Research and Development Department, Ichimaru Pharcos Co., Ltd., 318-1 Asagi, Gifu 501-0475, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Unno","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Akao","sequence":"additional","affiliation":[{"name":"United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"ref_1","unstructured":"Koch, H.P., and Lawson, L.D. (1996). History, folk medicine, and legendary uses of garlic. Garlic: The Science and Therapeutic Applications of Allium sativum L. and Related Species, William & Wilkins. [2nd ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/scientificamerican0385-114","article-title":"The chemistry of garlic and onions","volume":"252","author":"Block","year":"1985","journal-title":"Sci. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0021-9150(77)90044-2","article-title":"Controlled trial of the effect of cycloalliin on the fibrinolytic activity of venous blood","volume":"27","author":"Agarwal","year":"1977","journal-title":"Atherosclerosis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.3390\/nu4101518","article-title":"Anti-obesity effects of onion extract in Zucker diabetic fatty rats","volume":"4","author":"Yoshinari","year":"2012","journal-title":"Nutrients"},{"key":"ref_5","first-page":"79","article-title":"Studies on the mechanism of antihypertensive action of a constituents of garlic, \u03b3-glutamyl-S-allyl-cysteine (GSAC)","volume":"71","author":"Watabe","year":"2006","journal-title":"Oyo Yakuri (Pharmacomet.)"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3892\/etm.2012.819","article-title":"Effect of a traditional Japanese garlic preparation on blood pressure in prehypertensive and mildly hypertensive adults","volume":"5","author":"Nakasone","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1055\/s-2006-959461","article-title":"Pharmacokinetics of the garlic compound S-allylcysteine","volume":"60","author":"Nagae","year":"1994","journal-title":"Planta Med."},{"key":"ref_8","first-page":"61","article-title":"Pharmacokinetics and tissue distribution of s-allylcysteine in rats","volume":"5","author":"Yan","year":"2005","journal-title":"Asian J. Drug Metab. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1023\/A:1021946210399","article-title":"Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons","volume":"22","author":"Moriguchi","year":"1997","journal-title":"Neurochem. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1099-1573(199609)10:6<468::AID-PTR877>3.0.CO;2-I","article-title":"Trophic effects of aged garlic extract (AGE) and its fractions on primary cultured hippocampal neurons from fetal rat brain","volume":"10","author":"Moriguchi","year":"1996","journal-title":"Phytother. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0166-4328(94)00133-Z","article-title":"Neuronal growth factors, neurotrophins and memory deficiency","volume":"66","author":"Calamandrei","year":"1995","journal-title":"Behav. Brain Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.neuroscience.2003.08.026","article-title":"S-allyl-L-cysteine selectively protects cultured rat hippocampal neurons from amyloid beta-protein- and tunicamycin-induced neuronal death","volume":"122","author":"Kosuge","year":"2003","journal-title":"Neuroscience"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jphs.2016.03.004","article-title":"Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition","volume":"130","author":"Imai","year":"2016","journal-title":"J. Pharmacol. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00726-013-1628-4","article-title":"Protective effect of S-allyl-L-cysteine against endoplasmic reticulum stress-induced neuronal death is mediated by inhibition of calpain","volume":"46","author":"Imai","year":"2014","journal-title":"Amino Acids."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neulet.2007.09.042","article-title":"Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer\u2019s beta-amyloid fibrils in vitro","volume":"429","author":"Gupta","year":"2007","journal-title":"Neurosci. Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jep.2006.05.030","article-title":"Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer\u2019s transgenic model Tg2576","volume":"108","author":"Chauhan","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0047-6374(81)90084-1","article-title":"A new murine model of accelerated senescence","volume":"17","author":"Takeda","year":"1981","journal-title":"Mech. Ageing Dev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1532-5415.1991.tb04460.x","article-title":"Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence","volume":"39","author":"Takeda","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/00005072-199207000-00006","article-title":"Inbred SAM-P\/10 as a mouse model of spontaneous, inherited brain atrophy","volume":"51","author":"Shimada","year":"1992","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0306-4522(94)90290-9","article-title":"Localization of atrophy-prone areas in the aging mouse brain: Comparison between the brain atrophy model SAM-P\/10 and the normal control SAM-R\/1","volume":"59","author":"Shimada","year":"1994","journal-title":"Neuroscience"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2990.2006.00632.x","article-title":"Apical vulnerability to dendritic retraction in prefrontal neurones of ageing SAMP10 mouse: A model of cerebral degeneration","volume":"32","author":"Shimada","year":"2006","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/syn.10209","article-title":"Age-related loss of synapses in the frontal cortex of SAMP10 mouse: A model of cerebral degeneration","volume":"48","author":"Shimada","year":"2003","journal-title":"Synapse"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0006-8993(93)91467-7","article-title":"Age-related deterioration in conditional avoidance task in the SAM-P\/10 mouse, an animal model of spontaneous brain atrophy","volume":"608","author":"Shimada","year":"1993","journal-title":"Brain Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0531-5565(96)00061-7","article-title":"Characteristics of age-related behavioral changes in senescence-accelerated mouse SAMP8 and SAMP10","volume":"32","author":"Miyamoto","year":"1997","journal-title":"Exp. Gerontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0047-6374(00)00103-2","article-title":"Learning deficiency and alterations in acetylcholine receptors and protein kinase C in the brain of senescence-accelerated mouse (SAM)-P10","volume":"114","author":"Okuma","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0021-5198(19)30566-9","article-title":"Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10","volume":"83","author":"Onodera","year":"2000","journal-title":"Jpn. J. Pharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0531-5565(96)00062-9","article-title":"Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse","volume":"32","author":"Nishiyama","year":"1997","journal-title":"Exp. Gerontol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1440-1681.1997.tb01813.x","article-title":"Anti-ageing effect of aged garlic extract in the inbred brain atrophy mouse model","volume":"24","author":"Moriguchi","year":"1997","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.exger.2004.03.033","article-title":"Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)","volume":"39","author":"Unno","year":"2004","journal-title":"Exp. Gerontol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3793\/jaam.8.75","article-title":"Active component in green tea catechins and effective intake period for prevention of age-related brain dysfunction","volume":"8","author":"Unno","year":"2011","journal-title":"J. Anti Aging Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/biof.5520340402","article-title":"Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice","volume":"34","author":"Unno","year":"2008","journal-title":"Biofactors"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1471-4159.2010.07145.x","article-title":"Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model","volume":"117","author":"Ray","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_33","first-page":"348","article-title":"Federal support for training in laboratory animal medicine should be reinstated","volume":"49","author":"Jacoby","year":"1999","journal-title":"Lab. Anim. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/glia.22461","article-title":"Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice","volume":"61","author":"Ibi","year":"2013","journal-title":"Glia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/sj.bjp.0702595","article-title":"Nociceptin\/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice","volume":"127","author":"Hiramatsu","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0014-2999(93)90469-X","article-title":"Dynorphin A-(1\u201313) markedly improves scopolamine-induced impairment of spontaneous alternation performance in mice","volume":"236","author":"Itoh","year":"1993","journal-title":"Eur. J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1096\/fj.02-0448fje","article-title":"Cognition impairment in the genetic model of aging klotho gene mutant mice: A role of oxidative stress","volume":"17","author":"Nagai","year":"2003","journal-title":"FASEB J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.biopsych.2005.06.006","article-title":"Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1\/2 activation in the prefrontal cortex of mice","volume":"59","author":"Kamei","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1126\/science.284.5421.1811","article-title":"Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation","volume":"284","author":"Shi","year":"1999","journal-title":"Science"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1523\/JNEUROSCI.21-16-06008.2001","article-title":"Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors","volume":"21","author":"Liao","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/jnr.10551","article-title":"Ca2+\/calmodulin-dependent protein kinases II and IV function similarly in neurotrophic signaling but differ in their effects on neurite growth in spiral ganglion neurons","volume":"72","author":"Hansen","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0896-6273(02)00966-2","article-title":"Autophosphorylation of alphaCaMKII is required for ocular dominance plasticity","volume":"36","author":"Taha","year":"2002","journal-title":"Neuron"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrn753","article-title":"The molecular basis of CaMKII function in synaptic and behavioural memory","volume":"3","author":"Lisman","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13041-015-0166-2","article-title":"Calcium\/calmodulin-dependent kinase II and Alzheimer\u2019s disease","volume":"8","author":"Ghosh","year":"2015","journal-title":"Mol. Brain"},{"key":"ref_45","first-page":"196","article-title":"Communication networks in the brain: Neurons, receptors, neurotransmitters, and alcohol","volume":"31","author":"Lovinger","year":"2008","journal-title":"Alcohol Res. Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/sj.bjp.0704429","article-title":"[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivo","volume":"134","author":"Mamiya","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nn834","article-title":"Critical role of the hippocampus in memory for sequences of events","volume":"5","author":"Fortin","year":"2002","journal-title":"Nat. Neurosci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neubiorev.2004.06.006","article-title":"The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory","volume":"28","author":"Hughes","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/01.CHI.0000046835.90931.32","article-title":"Genetics of childhood disorders: L. Learning and memory, part 3: Fear conditioning","volume":"42","author":"Ressler","year":"2003","journal-title":"J. Am. Acad. Child. Adolesc. Psychiatry"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0959-4388(00)00195-1","article-title":"Role of perirhinal cortex in object perception, memory, and associations","volume":"11","author":"Murray","year":"2001","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.neuron.2014.09.037","article-title":"Cortical representations are reinstated by the hippocampus during memory retrieval","volume":"84","author":"Tanaka","year":"2014","journal-title":"Neuron"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1385\/MN:22:1-3:011","article-title":"Amygdala-hippocampus dynamic interaction in relation to memory","volume":"22","author":"Akirav","year":"2000","journal-title":"Mol. Neurobiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1037\/0033-2909.96.3.518","article-title":"Protein synthesis and memory: A review","volume":"96","author":"Davis","year":"1984","journal-title":"Psychol. Bull."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/1073858404265866","article-title":"Translational control at the synapse","volume":"10","author":"Wang","year":"2004","journal-title":"Neuroscientist"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.conb.2010.06.010","article-title":"Synaptic stability and plasticity in a floating world","volume":"20","author":"Gerrow","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/377115a0","article-title":"Contrasting properties of two forms of long-term potentiation in the hippocampus","volume":"377","author":"Nicoll","year":"1995","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/29305","article-title":"Maintenance of late-phase LTP is accompanied by PKA-dependent increase in AMPA receptor synthesis","volume":"394","author":"Nayak","year":"1998","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1146\/annurev.ne.17.030194.000335","article-title":"Cloned glutamate receptors","volume":"17","author":"Hollmann","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1073\/pnas.96.6.3269","article-title":"Ca2+\/calmodulin-kinase II enhances channel conductance of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors","volume":"96","author":"Derkach","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1098\/rstb.2002.1228","article-title":"Expression mechanisms underlying long-term potentiation: A postsynaptic view","volume":"358","author":"Nicoll","year":"2003","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnagi.2013.00039","article-title":"Evidence for loss of synaptic AMPA receptors in anterior piriform cortex of aged mice","volume":"5","author":"Gocel","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0006-8993(92)91293-N","article-title":"Mouse telencephalon exhibits an age-related decrease in glutamate (AMPA) receptors but no change in nerve terminal markers","volume":"589","author":"Bahr","year":"1992","journal-title":"Brain Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/jnr.490400210","article-title":"AMPA-selective glutamate receptor subunits in the rat hippocampus during aging","volume":"40","author":"Nicoletti","year":"1995","journal-title":"J. Neurosci. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0047-6374(98)00076-1","article-title":"Aging of glutamate receptors: Correlations between binding and spatial memory performance in mice","volume":"104","author":"Magnusson","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(00)02792-X","article-title":"Regional changes in the hippocampal density of AMPA and NMDA receptors across the lifespan of the rat","volume":"885","author":"Wenk","year":"2000","journal-title":"Brain Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fnagi.2014.00200","article-title":"Age-dependent modifications of AMPA receptor subunit expression levels and related cognitive effects in 3xTg-AD mice","volume":"6","author":"Cantanelli","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3204519","DOI":"10.1155\/2016\/3204519","article-title":"Amyloid-\u03b2-induced dysregulation of AMPA receptor trafficking","volume":"2016","author":"Guntupalli","year":"2016","journal-title":"Neural Plast."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3389\/fnmol.2017.00446","article-title":"AMPA receptor trafficking in natural and pathological aging","volume":"10","author":"Jurado","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1097\/01.wnr.0000185015.44563.5d","article-title":"Reduction of NR1 and phosphorylated Ca2+\/calmodulin-dependent protein kinase II levels in Alzheimer\u2019s disease","volume":"16","author":"Amada","year":"2005","journal-title":"Neuroreport"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: Long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1834\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:41:00Z","timestamp":1760175660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/6\/1834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,19]]},"references-count":70,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["nu12061834"],"URL":"https:\/\/doi.org\/10.3390\/nu12061834","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,19]]}}}