{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:41:40Z","timestamp":1780335700841,"version":"3.54.1"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016R1A2B4014740"],"award-info":[{"award-number":["NRF-2016R1A2B4014740"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Present study was conducted to investigate ameliorating effects of Mori Cortex radicis on cognitive impair and neuronal defects in HFD-induced (High Fat Diet-Induced) obese mice. To induce obesity, C57BL\/6 mice were fed an HFD for 8 weeks, and then mice were fed the HFD plus Mori Cortex radicis extract (MCR) (100 or 200 mg\/kg\/day) for 6 weeks. Prior to sacrifice, body weights were measured, and Y-maze test and oral glucose tolerance test were performed. Serum lipid metabolic biomarkers (TG, LDL, and HDL\/total cholesterol ratio) and antioxidant enzymes (glutathione, superoxide dismutase, and catalase), malondialdehyde (MDA), and acetylcholinesterase (AChE) levels were measured in brain tissues. The expressions of proteins related to insulin signaling (p-IRS, PI3K, p-Akt, and GLUT4) and neuronal protection (p-Tau, Bcl-2, and Bax) were examined. MCR suppressed weight gain, improved serum lipid metabolic biomarker and glucose tolerance, inhibited AChE levels and MDA production, and restored antioxidant enzyme levels in brain tissue. In addition, MCR induced neuronal protective effects by inhibiting p-Tau expression and increasing Bcl-2\/Bax ratio, which was attributed to insulin-induced increases in the expressions p-IRS, PI3K, p-Akt, and GLUT4. These indicate MCR may reduce HFD-induced insulin dysfunction and neuronal damage and suggest MCR be considered a functional material for the prevention of T2DM-associated neuronal disease.<\/jats:p>","DOI":"10.3390\/nu12061851","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T06:46:12Z","timestamp":1592808372000},"page":"1851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mori Cortex Radicis Attenuates High Fat Diet-Induced Cognitive Impairment via an IRS\/Akt Signaling Pathway"],"prefix":"10.3390","volume":"12","author":[{"given":"SoHyeon","family":"You","sequence":"first","affiliation":[{"name":"Department of Health Functional Materials, Duksung Women\u2019s University, Seoul 01369, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miran","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Food Science, Purdue University, West Lafayette, IN 47906, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun-Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Duksung Women\u2019s University, Seoul 01369, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1474-4422(17)30084-4","article-title":"Neurological consequences of obesity","volume":"16","author":"Hinder","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20463\/jenb.2018.0002","article-title":"Effects of treadmill exercise on PI3K\/AKT\/GSK-3\u03b2 pathway and tau protein in high-fat diet-fed rats","volume":"22","author":"Jeong","year":"2018","journal-title":"J. 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