{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T21:01:10Z","timestamp":1788037270183,"version":"build-2784847793"},"reference-count":48,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Butaphosphan is an organic phosphorus compound used in several species for the prevention of rapid catabolic states, however, the mechanism of action remains unclear. This study aimed at determining the effects of butaphosphan on energy metabolism of mice receiving a normal or hypercaloric diet (HCD) and submitted or not to food restriction. Two experiments were conducted: (1) during nine weeks, animals were fed with HCD (n = 28) ad libitum, and at the 10th week, were submitted to food restriction and received butaphosphan (n = 14) or saline injections (n = 14) (twice a day, for seven days) and; (2) during nine weeks, animals were fed with a control diet (n = 14) or HCD (n = 14) ad libitum, and at the 10th week, all animals were submitted to food restriction and received butaphosphan or saline injections (twice a day, for seven days). In food restriction, butaphosphan preserved epididymal white adipose tissue (WAT) mass, increased glucose, NEFA, and the HOMA index. In mice fed HCD and submitted to food restriction, the butaphosphan preserved epididymal WAT mass. Control diet influences on PI3K, GCK, and Irs1 mRNA expression. In conclusion, butaphosphan increased blood glucose and reduced fat mobilization in overweight mice submitted to caloric restriction, and these effects are influenced by diet.<\/jats:p>","DOI":"10.3390\/nu12061856","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T06:46:12Z","timestamp":1592808372000},"page":"1856","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Butaphosphan Effects on Glucose Metabolism Involve Insulin Signaling and Depends on Nutritional Plan"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-8686","authenticated-orcid":false,"given":"Maria Am\u00e9lia Agnes","family":"Weiller","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1413-5120","authenticated-orcid":false,"given":"Joao Alveiro","family":"Alvarado-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Bespalhok","family":"Jacometo","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"},{"name":"Programa de Zootecnia, Facultad de Ciencias Agropecuarias, Universidad de La Salle, Bogota DC 110231, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Castilho","family":"Barros","sequence":"additional","affiliation":[{"name":"Faculdade de Nutri\u00e7\u00e3o, Universidade Federal de Pelotas, Pelotas, RS 96010-610, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabel Cristina Cust\u00f3dio","family":"de Souza","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Teixeira","family":"Hax","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Casarin","family":"da Silva","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, 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Pelotas RS 96160-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens Alves","family":"Pereira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"},{"name":"Laborat\u00f3rio Ibasa, Porto Alegre RS 90220-030, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassio Cassal","family":"Brauner","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, Universidade Federal de Pelotas, Pelotas RS 96160-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane Rohrig","family":"Rabassa","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa, Ensino e Extens\u00e3o em Pecu\u00e1ria\u2014NUPEEC, Faculdade de Veterin\u00e1ria, 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