{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:17:16Z","timestamp":1789503436748,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T00:00:00Z","timestamp":1593216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>After a gastrectomy, the nutritional status of patients with gastric cancer has great effect on the treatment outcome and patients\u2019 quality of life. We investigated the changes in body composition and nutrient intake after gastrectomy in 288 gastric cancer patients. A multiple linear regression analysis was used for each time period to verify the effects of nutritional and clinical factors on weight and fat-free mass loss rates. Gastric cancer patients who underwent a gastrectomy continued to experience weight and fat-free mass loss until three months after surgery and became stagnant at six months. The marginal mean of calorie intake per weight was 24.5, 26.8, and 29.4 kcal at one, three, and six months. The protein intake per kg lean mass was 1.14, 1.14, and 1.16 g at one, three, and six months, respectively. One month after surgery, the rate of weight loss increased significantly in females who received chemotherapy (p &lt; 0.001). At one to three months postoperative, females who had undergone chemotherapy tended to significantly lose weight (p = 0.016). Females with a history of chemotherapy also showed a reduction in fat-free mass for one to three months (p = 0.036). Calorie intake was a significant factor in preventing fat-free mass weight loss at one month after surgery. Chemotherapy was an independent factor affecting the weight and fat-free mass loss rate up to six months after gastrectomy. Careful monitoring of weight and muscle mass changes following active nutritional intervention for sufficient nutrition support could be helpful for patients after gastrectomy.<\/jats:p>","DOI":"10.3390\/nu12071905","type":"journal-article","created":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T05:28:56Z","timestamp":1593408536000},"page":"1905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Nutritional and Clinical Factors Affecting Weight and Fat-Free Mass Loss after Gastrectomy in Patients with Gastric Cancer"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-8906","authenticated-orcid":false,"given":"Hee-Sook","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Yeonsung University, Anyang 14011, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Statistics, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-0679","authenticated-orcid":false,"given":"In","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyu Seok","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon 14584, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_2","unstructured":"Ministry of Health & Welfare, Korean Central Cancer Registry, and National Cancer Center (2015). Annual Report of Cancer Statistics in Korea, 2013, Korea Cancer Center Registry."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10120-018-0893-z","article-title":"Long-term quality of life and nutrition status of the aboral pouch reconstruction after total gastrectomy for gastric cancer: A prospective multicenter observational study (CCOG1505)","volume":"22","author":"Tanaka","year":"2019","journal-title":"Gastric Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/jhn.12588","article-title":"Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago-gastric cancer: A longitudinal cohort study","volume":"31","author":"Grace","year":"2018","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.3748\/wjg.v16.i26.3310","article-title":"Comparison of different nutritional assessments in detecting malnutrition among gastric cancer patients","volume":"16","author":"Ryu","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S778","DOI":"10.1245\/s10434-015-4820-9","article-title":"Prevalence of Malnutrition Among Gastric Cancer Patients Undergoing Gastrectomy and Optimal Preoperative Nutritional Support for Preventing Surgical Site Infections","volume":"22","author":"Fukuda","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S0016-5085(55)80003-0","article-title":"The problem of nutrition following total gastrectomy","volume":"28","author":"Johnson","year":"1955","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.amsu.2015.08.010","article-title":"Quality of life after subtotal gastrectomy for gastric cancer: Does restoration method matter? A retrospective cohort study","volume":"4","author":"Smolskas","year":"2015","journal-title":"Ann. Med. Surg. (London)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000445188","article-title":"Nutrition in Patients with Gastric Cancer: An Update","volume":"2","author":"Rosania","year":"2016","journal-title":"Gastrointest. Tumors"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ejca.2015.10.061","article-title":"Survival impact of postoperative body mass index in gastric cancer patients undergoing gastrectomy","volume":"52","author":"Lee","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"ref_11","first-page":"87","article-title":"Nutritional Status After Total Gastrectomy for Gastric Cancer","volume":"1","author":"Cidon","year":"2010","journal-title":"World J. Oncol."},{"key":"ref_12","first-page":"785","article-title":"A study on nutritional status after gastrectomy of gastric cancer patients in Jeonbuk province","volume":"11","author":"Jeong","year":"2006","journal-title":"Korean J. Community Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/00365526709180059","article-title":"The clinical and metabolic consequences of total gastrectomy. I. Morbidity, weight, and nutrition","volume":"2","author":"Adams","year":"1967","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clnesp.2019.08.012","article-title":"Associations between skeletal muscle mass index, nutritional and functional status of patients with oesophago-gastric cancer","volume":"34","author":"Lidoriki","year":"2019","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.biocel.2013.05.032","article-title":"Muscle wasting in cancer","volume":"45","author":"Johns","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1245\/s10434-017-5811-9","article-title":"Prognostic significance of sarcopenia in patients with esophagogastric junction cancer or upper gastric cancer","volume":"24","author":"Kudou","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4166\/kjg.2013.61.4.186","article-title":"Nutritional assessment and perioperative nutritional support in gastric cancer patients","volume":"61","author":"Seo","year":"2013","journal-title":"Korean J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1207\/S15327914NC421_7","article-title":"A randomized study of nutritional support in patients with colorectal and gastric cancer","volume":"42","author":"Persson","year":"2002","journal-title":"Nutr. Cancer"},{"key":"ref_19","first-page":"72","article-title":"A study of dietary intakes and nutritional status after total gastrectomy of early gastric cancer patients","volume":"7","author":"Kim","year":"2001","journal-title":"J. Korean Diet. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153","DOI":"10.7762\/cnr.2015.4.3.153","article-title":"Comparison of Quality of Life and Nutritional Status in Gastric Cancer Patients Undergoing Gastrectomies","volume":"4","author":"Lim","year":"2015","journal-title":"Clin. Nutr. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.2217\/fon-2019-0539","article-title":"Patient-generated subjective global assessment versus nutritional risk screening 2002 for gastric cancer in Chinese patients","volume":"16","author":"Yang","year":"2020","journal-title":"Future Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/s41430-019-0502-1","article-title":"Association among the prognostic nutritional index, completion of adjuvant chemotherapy, and cancer-specific survival after curative resection of stage II\/III gastric cancer","volume":"74","author":"Xiao","year":"2020","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4162\/nrp.2012.6.3.213","article-title":"Evaluation of nutrient intake and diet quality of gastric cancer patients in Korea","volume":"6","author":"Lim","year":"2012","journal-title":"Nutr. Res. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.dld.2003.09.005","article-title":"Nutrient intake and gastric cancer in residents of Zhoushan Islands, China","volume":"35","author":"Chen","year":"2003","journal-title":"Dig. Liver Dis."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Geisler, C., Prado, C., and M\u00fcller, M. (2017). Inadequacy of body weight-based recommendations for individual protein intake\u2014Lessons from body composition analysis. Nutrients, 9.","DOI":"10.3390\/nu9010023"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1038\/s41430-018-0245-4","article-title":"Cancer-associated malnutrition","volume":"72","author":"Baracos","year":"2018","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00268-002-6286-8","article-title":"Gastrointestinal recovery and outcome after laparoscopy-assisted versus conventional open distal gastrectomy for early gastric cancer","volume":"26","author":"Mochiki","year":"2002","journal-title":"World J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/bjs.9221","article-title":"Body mass index and outcomes following gastrointestinal cancer surgery in Japan","volume":"100","author":"Yasunaga","year":"2013","journal-title":"Br. J. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.clnu.2010.07.015","article-title":"Associations between nutritional status, weight loss, radiotherapy treatment toxicity and treatment outcomes in gastrointestinal cancer patients","volume":"30","author":"Hill","year":"2011","journal-title":"Clin. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0959-8049(97)10090-9","article-title":"Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?","volume":"34","author":"Andreyev","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S929","DOI":"10.1245\/s10434-015-4590-4","article-title":"Feasibility and Nutritional Benefits of Laparoscopic Proximal Gastrectomy for Early Gastric Cancer in the Upper Stomach","volume":"22","author":"Kosuga","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.3892\/ol.2017.6286","article-title":"Outcome predictors for patients with stage II\/III gastric cancer who undergo gastrectomy and S-1 adjuvant chemotherapy","volume":"14","author":"Fujiwara","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.3748\/wjg.v23.i26.4823","article-title":"Predictive factors for body weight loss and its impact on quality of life following gastrectomy","volume":"23","author":"Tanabe","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/01635581.2017.1267774","article-title":"Weight Loss During Initial Chemotherapy Predicts Survival in Patients with Advanced Gastric Cancer","volume":"69","author":"Takayoshi","year":"2017","journal-title":"Nutr. Cancer"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10120-015-0481-4","article-title":"Weight loss at the first month of palliative chemotherapy predicts survival outcomes in patients with advanced gastric cancer","volume":"19","author":"Ock","year":"2016","journal-title":"Gastric Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrclinonc.2012.209","article-title":"Understanding the mechanisms and treatment options in cancer cachexia","volume":"10","author":"Fearon","year":"2013","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.clnu.2011.08.008","article-title":"Marked changes in body composition following neoadjuvant chemotherapy for oesophagogas gastric cancer","volume":"31","author":"Awad","year":"2012","journal-title":"Clin. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/MCO.0b013e3283455d45","article-title":"Two faces of drug therapy in cancer: Drug-related lean tissue loss and its adverse consequences to survival and toxicity","volume":"14","author":"Prado","year":"2011","journal-title":"Curr. Opin. Nutr. Metab. Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/bjs.10417","article-title":"Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer","volume":"104","author":"Ida","year":"2017","journal-title":"Br. J. Surg."},{"key":"ref_40","unstructured":"Ministry of Health & Welfare, and The Korean Nutrition Society (2015). Dietary Reference Intakes for Koreans, The Korean Nutrition Society."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00268-005-7760-x","article-title":"Patient-controlled dietary schedule improves clinical outcome after gastrectomy for gastric cancer","volume":"29","author":"Hirao","year":"2005","journal-title":"World J. Surg."},{"key":"ref_42","first-page":"844","article-title":"A study of nutritional assessment and dietary intake after gastrectomy of gastric cancer patients","volume":"27","author":"Kim","year":"1994","journal-title":"Korean J. Nutr."}],"container-title":["Nutrients"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/7\/1905\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:43:36Z","timestamp":1760175816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6643\/12\/7\/1905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,27]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7]]}},"alternative-id":["nu12071905"],"URL":"https:\/\/doi.org\/10.3390\/nu12071905","relation":{},"ISSN":["2072-6643"],"issn-type":[{"value":"2072-6643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,27]]}}}