{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:57:53Z","timestamp":1777564673238,"version":"3.51.4"},"reference-count":62,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011721","name":"Chronic Disease Research Foundation","doi-asserted-by":"publisher","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/100011721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Nutrition plays a key role in blood pressure (BP) regulation. Here, we examine associations between nutrient intakes and BP in a large predominantly female population-based cohort. We assessed the correlation between 45 nutrients (from food frequency questionnaires) and systolic BP\/diastolic BP (SBP\/DBP) in 3889 individuals from TwinsUK not on hypertensive treatments and replicated in an independent subset of monozygotic twins discordant for nutrient intake (17\u2013242 pairs). Results from both analyses were meta-analysed. For significant nutrients, we calculated heritability using structural equation modelling. We identified and replicated 15 nutrients associated with SBP, 9 also being associated with DBP, adjusting for covariates and multiple testing. 14 of those had a heritable component (h2: 27.1\u201357.6%). Strong associations with SBP were observed for riboflavin (Beta(SE) = \u22121.49(0.38), P = 1.00 \u00d7 10\u22124) and tryptophan (\u22120.31(0.01), P = 5 \u00d7 10\u22124), while with DBP for alcohol (0.05(0.07), P = 1.00 \u00d7 10\u22124) and lactose (\u22120.05(0.0), P = 1.3 \u00d7 10\u22123). Two multivariable nutrient scores, combining independently SBP\/DBP-associated nutrients, explained 22% of the variance in SBP and 13.6% of the variance in DBP. Moreover, bivariate heritability analysis suggested that nutrients and BP share some genetic influences. We confirm current understanding and extend the panel of dietary nutrients implicated in BP regulation underscoring the value of nutrient focused dietary research in preventing and managing hypertension.<\/jats:p>","DOI":"10.3390\/nu12072130","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T10:22:02Z","timestamp":1594981322000},"page":"2130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dietary Influence on Systolic and Diastolic Blood Pressure in the TwinsUK Cohort"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-1433","authenticated-orcid":false,"given":"Panayiotis","family":"Louca","sequence":"first","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olatz","family":"Mompeo","sequence":"additional","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Leeming","sequence":"additional","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, King\u2019s College London, London WC2R 2LS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Mangino","sequence":"additional","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK"},{"name":"NIHR Biomedical Research Centre at Guy\u2019s and St Thomas\u2019 Foundation Trust, London SE1 9RT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim D.","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3869-5808","authenticated-orcid":false,"given":"Sandosh","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular &amp; Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-0571","authenticated-orcid":false,"given":"Cristina","family":"Menni","sequence":"additional","affiliation":[{"name":"Department of Twin Research, King\u2019s College London, St Thomas\u2019 Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/jamacardio.2017.1421","article-title":"Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis","volume":"2","author":"Bundy","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archinte.1995.00430070053006","article-title":"Implications of small reductions in diastolic blood pressure for primary prevention","volume":"155","author":"Cook","year":"1995","journal-title":"Arch. 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