{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:08:26Z","timestamp":1790136506684,"version":"4.0.1"},"reference-count":58,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["AGL2017-83477-R"],"award-info":[{"award-number":["AGL2017-83477-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007512","name":"Universitat Rovira i Virgili","doi-asserted-by":"publisher","award":["Mart\u00ed Franqu\u00e9s"],"award-info":[{"award-number":["Mart\u00ed Franqu\u00e9s"]}],"id":[{"id":"10.13039\/501100007512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002943","name":"Departament d'Innovaci\u00f3, Universitats i Empresa, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["Serra H\u00fanter"],"award-info":[{"award-number":["Serra H\u00fanter"]}],"id":[{"id":"10.13039\/501100002943","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>In this study we compare the interaction of three protein sources\u2014insect, beef, and almond\u2014with the gastrointestinal tract. We measured the enterohormone secretion ex vivo in human and pig intestine treated with in vitro digestions of these foods. Insect and beef were the most effective in inducing the secretion of CCK, while almond was the most effective in inducing PYY in pig duodenum. In the human colon, almond was also the most effective in inducing PYY, and GLP-1 levels were increased by insect and beef. The three digested proteins reduced ghrelin secretion in pig duodenum, while only insect reduced ghrelin secretion in human colon. We also found that food intake in rats increased in groups fed a raw insect pre-load and decreased when fed raw almond. In conclusion, the insect Alphitobius diaperinus modulates duodenal and colonic enterohormone release and increases food intake in rats. These effects differ from beef and almond.<\/jats:p>","DOI":"10.3390\/nu12082366","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T10:16:23Z","timestamp":1596795383000},"page":"2366","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Gastrointestinally Digested Protein from the Insect Alphitobius diaperinus Stimulates a Different Intestinal Secretome than Beef or Almond, Producing a Differential Response in Food Intake in Rats"],"prefix":"10.3390","volume":"12","author":[{"given":"Alba","family":"Migu\u00e9ns-G\u00f3mez","sequence":"first","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-9607","authenticated-orcid":false,"given":"Carme","family":"Grau-Bov\u00e9","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Sierra-Cruz","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Jorba-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia General i de l\u2019Aparell Digestiu, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6151-3879","authenticated-orcid":false,"given":"Aleidis","family":"Caro","sequence":"additional","affiliation":[{"name":"Servei de Cirurgia General i de l\u2019Aparell Digestiu, Hospital Universitari Joan XXIII, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6363-2510","authenticated-orcid":false,"given":"Esther","family":"Rodr\u00edguez-Gallego","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Beltr\u00e1n-Deb\u00f3n","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-9847","authenticated-orcid":false,"given":"M Teresa","family":"Blay","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-5844","authenticated-orcid":false,"given":"Ximena","family":"Terra","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-7538","authenticated-orcid":false,"given":"Anna","family":"Ard\u00e9vol","sequence":"additional","affiliation":[{"name":"MoBioFood Research Group, Departament de Bioqu\u00edmica i Biotecnologia, Universitat Rovira i Virgili, c\/Marcel\u00b7l\u00ed Domingo n 1, 43007 Tarragona, Spain"},{"name":"Institut d\u2019Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV), 43007 Tarragona, 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