{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:22:59Z","timestamp":1773796979070,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T00:00:00Z","timestamp":1596931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chi Mei Medical Center, Tainan, Taiwan","award":["107CM-TMU-12"],"award-info":[{"award-number":["107CM-TMU-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nutrients"],"abstract":"<jats:p>Vitamin C deficiency increases the risk of postherpetic neuralgia (PHN). In this cross-sectional study, the relationships among plasma vitamin C concentrations, pain and Leeds assessment of neuropathic symptoms and signs (LANSS) items were investigated during their first pain clinic visit of 120 PHN patients. The factors associated with vitamin C deficiency were determined. Independent predictors of vitamin C deficiency were presented as adjusted odds ratios (AOR) and 95% confidence intervals (CI). The patients had a high prevalence (52.5%) of vitamin C deficiency. Their plasma vitamin C concentrations were negatively associated with spontaneous pain and tingling, prickling or pins and needles sensation according to the LANSS questionnaire. Based on the receiver operator characteristic curve, the cutoffs for plasma vitamin C to predict moderate-to-severe and severe symptoms of sharp sensation were &lt;7.05 and &lt;5.68 mg\/L, respectively. By comparison, the patients well-nourished with vitamin C had lower incidences of sharp sensations, sharp pain, and reddish skin. Multivariate analyses revealed that vitamin C deficiency was associated with the low intake of fruit\/vegetables (AOR 2.66, 95% CI 1.09\u20136.48, p = 0.032), peptic ulcer disease (AOR 3.25, 95% CI 1.28\u20138.28, p = 0.014), and smoking (AOR 3.60, 95% CI 1.33\u20139.77, p = 0.010). Future studies are needed to substantiate these findings.<\/jats:p>","DOI":"10.3390\/nu12082384","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T05:07:23Z","timestamp":1597036043000},"page":"2384","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8640-8231","authenticated-orcid":false,"given":"Li-Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-Tsung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Center of General Education, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-8085","authenticated-orcid":false,"given":"Kuo-Chuan","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Health and Nutrition, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Center for General Education, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-9085","authenticated-orcid":false,"given":"Zhi-Fu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Anesthesiology, Tri-Service General Hospital and National Defense Medical Center, Taipei 11490, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao-Lin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Food Science and Applied Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-5701","authenticated-orcid":false,"given":"Jen-Yin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan 71004, Taiwan"},{"name":"Department of Senior Citizen Service Management, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4065\/82.11.1341","article-title":"A population-based study of the incidence and complication rates of herpes zoster before zoster vaccine introduction","volume":"82","author":"Yawn","year":"2007","journal-title":"Mayo Clin. 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